ATE198046T1 - Neue hemmer von uridinphosphorylase (urdpase) und dihydrouracildehydrogenase (dhudase) - Google Patents
Neue hemmer von uridinphosphorylase (urdpase) und dihydrouracildehydrogenase (dhudase)Info
- Publication number
- ATE198046T1 ATE198046T1 AT94929398T AT94929398T ATE198046T1 AT E198046 T1 ATE198046 T1 AT E198046T1 AT 94929398 T AT94929398 T AT 94929398T AT 94929398 T AT94929398 T AT 94929398T AT E198046 T1 ATE198046 T1 AT E198046T1
- Authority
- AT
- Austria
- Prior art keywords
- ins
- compounds
- dhudase
- urdpase
- date
- Prior art date
Links
- 108010019092 Uridine phosphorylase Proteins 0.000 title abstract 3
- 102100022334 Dihydropyrimidine dehydrogenase [NADP(+)] Human genes 0.000 title 2
- 108010088106 Dihydrouracil Dehydrogenase (NAD+) Proteins 0.000 title 2
- 102000006405 Uridine phosphorylase Human genes 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 methoxy, benzyl Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052711 selenium Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/146,838 US5476855A (en) | 1993-11-02 | 1993-11-02 | Enzyme inhibitors, their synthesis and methods for use |
| PCT/US1994/011173 WO1995012400A1 (en) | 1993-11-02 | 1994-09-30 | Novel enzyme inhibitors, their synthesis, and methods for use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198046T1 true ATE198046T1 (de) | 2000-12-15 |
Family
ID=22519188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94929398T ATE198046T1 (de) | 1993-11-02 | 1994-09-30 | Neue hemmer von uridinphosphorylase (urdpase) und dihydrouracildehydrogenase (dhudase) |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5476855A (https=) |
| EP (1) | EP0725641B1 (https=) |
| JP (1) | JP3621102B2 (https=) |
| AT (1) | ATE198046T1 (https=) |
| AU (1) | AU699914B2 (https=) |
| DE (1) | DE69426423T2 (https=) |
| ES (1) | ES2155093T3 (https=) |
| PT (1) | PT725641E (https=) |
| WO (1) | WO1995012400A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476855A (en) * | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| EP0748316B1 (en) * | 1994-02-28 | 2002-05-08 | Sunkyong Industries Co., Ltd. | Pyrimidine acyclonucleoside derivatives |
| US5811073A (en) * | 1995-06-19 | 1998-09-22 | President And Fellows Of Harvard College | Method for radioisotopic detection and localization of inflammation in a host |
| US5719132A (en) * | 1996-06-27 | 1998-02-17 | Bristol-Myers Squibb Company | Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil |
| US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| US6177437B1 (en) * | 1998-09-04 | 2001-01-23 | University Of Massachusetts Medical Center | Inhibitors of Herpes Simplex virus uracil-DNA glycosylase |
| WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| US7501429B2 (en) * | 2001-04-11 | 2009-03-10 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| JP2004536071A (ja) * | 2001-05-25 | 2004-12-02 | クイーンズ ユニバーシティ アット キングストン | 複素環ベータアミノ酸およびそれらの抗癲癇誘発剤としての使用 |
| US8592421B2 (en) * | 2003-08-04 | 2013-11-26 | Valery Khazhmuratovich Zhilov | Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon |
| JP2008521930A (ja) * | 2004-12-03 | 2008-06-26 | アドヘレックス テクノロジーズ， インコーポレイテッド | ５−ｆｕおよび５−ｆｕプロドラッグと併用してｄｐｄ阻害物質を投与するための方法 |
| US20100158967A1 (en) * | 2005-05-24 | 2010-06-24 | Ted Reid | Selenium-based biocidal formulations and methods of use thereof |
| WO2007008293A2 (en) * | 2005-05-24 | 2007-01-18 | Selenium, Ltd. | Selenium-based biocidal formulations and methods of use thereof |
| US20100158966A1 (en) * | 2005-05-24 | 2010-06-24 | Ted Reid | Selenium-based biocidal formulations and methods of use thereof |
| US9370187B2 (en) | 2005-05-24 | 2016-06-21 | Selenium, Ltd. | Selenium-based biocidal formulations and methods of use thereof |
| WO2007024863A2 (en) * | 2005-08-22 | 2007-03-01 | Melior Discovery, Inc. | Methods and formulations for modulating lyn kinase activity and treating related disorders |
| BRPI0807928A2 (pt) * | 2007-02-20 | 2014-07-08 | Melior Pharmaceuticals I Inc | Métodos para identificar um ativador de lyn quinase, e para tratar diabetes em um humano, kit, e, composição |
| CA2693809A1 (en) * | 2007-07-23 | 2009-01-29 | Melior Discovery, Inc. | Methods of activating irs-1 and akt |
| CN102014919B (zh) | 2008-03-03 | 2015-02-25 | 托斯克公司 | 减少毒性的甲氨蝶呤佐剂及其使用方法 |
| US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| WO2010080086A1 (en) * | 2009-01-12 | 2010-07-15 | Selenium, Ltd. | Anti-microbial orthodontic compositions and appliances and methods of production and use thereof |
| JP2013508293A (ja) * | 2009-10-14 | 2013-03-07 | アドヘレックス テクノロジーズ， インコーポレイテッド | ５−ｆｕ又はそのプロドラッグと、ｄｐｄ阻害剤との組合せに付随した神経毒性の処置 |
| US20130158055A1 (en) | 2010-05-28 | 2013-06-20 | Andrew G. Reaume | Prevention Of Pancreatic Beta Cell Degeneration |
| KR102634575B1 (ko) | 2017-04-10 | 2024-02-06 | 멜리어 파마슈티칼스 아이, 인코포레이티드 | 지방세포의 처리 |
| US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| WO2025260023A1 (en) * | 2024-06-14 | 2025-12-18 | Spiral Therapeutics, Inc. | Methods of treating otic disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3755295A (en) * | 1969-10-24 | 1973-08-28 | Syntex Corp | 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof |
| US3687931A (en) * | 1970-03-19 | 1972-08-29 | Syntex Corp | Halogenated purine and pyrimidine nucleosides and process therefor |
| JPS5738774A (en) * | 1980-08-19 | 1982-03-03 | Chugai Pharmaceut Co Ltd | Uracil derivative and its preparation |
| US4868187A (en) * | 1980-09-16 | 1989-09-19 | Syntex (U.S.A.) Inc. | Anti-viral N-substituted pyrimidines |
| US4613604A (en) * | 1985-07-31 | 1986-09-23 | Brown University Research Foundation | Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine |
| WO1989009213A1 (fr) * | 1988-03-31 | 1989-10-05 | Mitsubishi Kasei Corporation | Derives de nucleoside de pyrimidine acyclique substitue en 6 et agents antiviraux contenant ces composes en tant qu'ingredients actifs |
| US5077280A (en) * | 1988-04-12 | 1991-12-31 | Brown University Research Foundation | Treatment of viral infections |
| EP0449726B1 (en) * | 1990-03-29 | 1997-06-11 | Mitsubishi Chemical Corporation | Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient |
| US5141943A (en) * | 1990-04-12 | 1992-08-25 | Brown University Research Foundation | 5-benzyl barbiturate derivatives |
| US5476855A (en) * | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| KR0151811B1 (ko) * | 1993-12-21 | 1998-10-15 | 강박광 | 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법 |
-
1993
- 1993-11-02 US US08/146,838 patent/US5476855A/en not_active Ceased
-
1994
- 1994-09-30 AT AT94929398T patent/ATE198046T1/de not_active IP Right Cessation
- 1994-09-30 JP JP51321195A patent/JP3621102B2/ja not_active Expired - Fee Related
- 1994-09-30 AU AU78476/94A patent/AU699914B2/en not_active Ceased
- 1994-09-30 ES ES94929398T patent/ES2155093T3/es not_active Expired - Lifetime
- 1994-09-30 WO PCT/US1994/011173 patent/WO1995012400A1/en not_active Ceased
- 1994-09-30 EP EP94929398A patent/EP0725641B1/en not_active Expired - Lifetime
- 1994-09-30 PT PT94929398T patent/PT725641E/pt unknown
- 1994-09-30 DE DE69426423T patent/DE69426423T2/de not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/466,470 patent/US5721241A/en not_active Expired - Lifetime
-
1997
- 1997-12-01 US US08/980,629 patent/USRE37623E1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0725641A1 (en) | 1996-08-14 |
| JPH09507054A (ja) | 1997-07-15 |
| AU7847694A (en) | 1995-05-23 |
| DE69426423D1 (de) | 2001-01-18 |
| PT725641E (pt) | 2001-05-31 |
| DE69426423T2 (de) | 2001-07-12 |
| EP0725641A4 (https=) | 1996-09-04 |
| ES2155093T3 (es) | 2001-05-01 |
| JP3621102B2 (ja) | 2005-02-16 |
| US5476855A (en) | 1995-12-19 |
| WO1995012400A1 (en) | 1995-05-11 |
| AU699914B2 (en) | 1998-12-17 |
| US5721241A (en) | 1998-02-24 |
| EP0725641B1 (en) | 2000-12-13 |
| USRE37623E1 (en) | 2002-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |