ATE197963T1 - Stereoselektive mikrobielle oder enzymatische reduktion von 3,5-dioxoestern zu 3,5- dihydroxyestern - Google Patents

Stereoselektive mikrobielle oder enzymatische reduktion von 3,5-dioxoestern zu 3,5- dihydroxyestern

Info

Publication number
ATE197963T1
ATE197963T1 AT93107876T AT93107876T ATE197963T1 AT E197963 T1 ATE197963 T1 AT E197963T1 AT 93107876 T AT93107876 T AT 93107876T AT 93107876 T AT93107876 T AT 93107876T AT E197963 T1 ATE197963 T1 AT E197963T1
Authority
AT
Austria
Prior art keywords
dioxoesters
dihydroxyesters
enzymatic reduction
chem
stereoselective microbial
Prior art date
Application number
AT93107876T
Other languages
English (en)
Inventor
Ramesh N Patel
Clyde G Mcnamee
Amit Banerjee
Laszlo J Szarka
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of ATE197963T1 publication Critical patent/ATE197963T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/938—Pichia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93107876T 1992-05-15 1993-05-14 Stereoselektive mikrobielle oder enzymatische reduktion von 3,5-dioxoestern zu 3,5- dihydroxyestern ATE197963T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/883,732 US5324662A (en) 1992-05-15 1992-05-15 Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters

Publications (1)

Publication Number Publication Date
ATE197963T1 true ATE197963T1 (de) 2000-12-15

Family

ID=25383221

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93107876T ATE197963T1 (de) 1992-05-15 1993-05-14 Stereoselektive mikrobielle oder enzymatische reduktion von 3,5-dioxoestern zu 3,5- dihydroxyestern

Country Status (10)

Country Link
US (1) US5324662A (de)
EP (1) EP0569998B1 (de)
JP (1) JP3476860B2 (de)
AT (1) ATE197963T1 (de)
CA (1) CA2094191C (de)
DE (1) DE69329719T2 (de)
DK (1) DK0569998T3 (de)
ES (1) ES2152234T3 (de)
GR (1) GR3035316T3 (de)
PT (1) PT569998E (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
CA2305564C (en) 1998-08-05 2008-06-17 Kaneka Corporation Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
DE19937825B4 (de) * 1999-07-09 2005-08-11 Forschungszentrum Jülich GmbH Verfahren zur Reduktion von Hydroxyketo-Carbonsäuren und deren Estern
WO2001004336A1 (de) 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
AU2002228413B8 (en) 2001-02-02 2007-03-22 Mitsubishi Chemical Corporation Process for producing (3R,5S)-(E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-Quinolin-3-yl]-3,5-Dihydroxyhept -6-enic acid esters
WO2004027075A2 (en) * 2002-09-20 2004-04-01 Diversa Corporation Chemoenzymatic methods for the synthesis of statins and stain intermediates
AT503017B1 (de) 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
CN101429514B (zh) * 2007-11-08 2011-06-15 陈依军 一种双羰基还原酶、其基因及其应用
CN101880694B (zh) * 2009-12-01 2014-06-11 陈依军 一种非水相制备手性3r,5s-双羟基化合物的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3278204D1 (en) * 1981-11-28 1988-04-14 Sumitomo Chemical Co Method for biotechnologically preparing (s)-(-)-alpha-cyano-3-phenoxybenzyl alcohol
IE56322B1 (en) 1982-12-06 1991-06-19 Sigma Tau Ind Farmaceuti Process for preparing l-carnitine and chemical intermediates employed therein
DE3377653D1 (en) * 1983-03-18 1988-09-15 Sumitomo Chemical Co Process for biochemical optical resulution of cyclopentenolone derivative
EP0144832A3 (de) * 1983-12-06 1987-01-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung optisch aktiver, alpha-substituierter 3-Hydroxypropionsäurederivate
US4584270A (en) * 1984-01-23 1986-04-22 Wisconsin Alumni Research Foundation Process for preparing optically-active 4-amino-3-hydroxybutyric acid
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4601987A (en) * 1985-02-27 1986-07-22 Massachusetts Institute Of Technology Enzymatic production of optical isomers of 2-halopropionic acids
US4870199A (en) 1986-04-30 1989-09-26 Sandoz Pharm. Corp. Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DE3724197A1 (de) * 1987-07-22 1989-02-02 Merck Patent Gmbh Verfahren zur reduktion von ketonen
IT1216743B (it) * 1988-02-10 1990-03-08 Donegani Guido Ist Processo per la preparazioenenzimatica degli isomeri ottici di alcoli primari alfa alchilsostituiti racemi.
GB2244705B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof
CA1318627C (en) * 1988-07-14 1993-06-01 Jeffrey M. Howell Enzymatic resolution process
CH675882A5 (en) 1988-12-01 1990-11-15 Eidgenoess Tech Hochschule Optically active 3-hydroxy:alkanoate ester prodn. - from corresp. 3-oxo ester by continuous redn. with yeast under acidic conditions
CA2008702A1 (en) * 1989-02-27 1990-08-27 Ronald L. Hanson Process for transformation of hydroxyketo acids to hydroxyamino acids
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5084387A (en) * 1990-12-18 1992-01-28 E. R. Squibb & Sons, Inc. Microbiological hydrolysis for the preparation of (exo,exo)-7-oxabicyclo(2.2.1) heptane-2,3, monoacyl ester dimethanol

Also Published As

Publication number Publication date
JP3476860B2 (ja) 2003-12-10
US5324662A (en) 1994-06-28
JPH0630783A (ja) 1994-02-08
EP0569998B1 (de) 2000-12-06
DK0569998T3 (da) 2001-01-08
DE69329719D1 (de) 2001-01-11
CA2094191C (en) 2003-09-23
PT569998E (pt) 2001-03-30
ES2152234T3 (es) 2001-02-01
CA2094191A1 (en) 1993-11-16
EP0569998A2 (de) 1993-11-18
DE69329719T2 (de) 2001-07-05
EP0569998A3 (de) 1995-04-05
GR3035316T3 (en) 2001-04-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee