ATE196658T1 - Verfahren zum aufspüren von nukleosidanalogen, die durch die reverse transcriptase aus hiv eingebaut werden und falsche basenpaarung verursachen - Google Patents

Verfahren zum aufspüren von nukleosidanalogen, die durch die reverse transcriptase aus hiv eingebaut werden und falsche basenpaarung verursachen

Info

Publication number
ATE196658T1
ATE196658T1 AT95925292T AT95925292T ATE196658T1 AT E196658 T1 ATE196658 T1 AT E196658T1 AT 95925292 T AT95925292 T AT 95925292T AT 95925292 T AT95925292 T AT 95925292T AT E196658 T1 ATE196658 T1 AT E196658T1
Authority
AT
Austria
Prior art keywords
hiv
reverse transcriptase
base pairing
nucleoside analogues
incorrect base
Prior art date
Application number
AT95925292T
Other languages
English (en)
Inventor
Lawrence A Loeb
John M Essigmann
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE196658T1 publication Critical patent/ATE196658T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT95925292T 1994-06-29 1995-06-22 Verfahren zum aufspüren von nukleosidanalogen, die durch die reverse transcriptase aus hiv eingebaut werden und falsche basenpaarung verursachen ATE196658T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/268,686 US5512431A (en) 1994-06-29 1994-06-29 Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing
PCT/US1995/007937 WO1996000797A1 (en) 1994-06-29 1995-06-22 Methods of screening for nucleoside analogs that are incorporated by hiv reverse transcriptase and cause incorrect base pairing

Publications (1)

Publication Number Publication Date
ATE196658T1 true ATE196658T1 (de) 2000-10-15

Family

ID=23024043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925292T ATE196658T1 (de) 1994-06-29 1995-06-22 Verfahren zum aufspüren von nukleosidanalogen, die durch die reverse transcriptase aus hiv eingebaut werden und falsche basenpaarung verursachen

Country Status (8)

Country Link
US (2) US5512431A (de)
EP (2) EP1004675A3 (de)
JP (3) JP4231550B2 (de)
AT (1) ATE196658T1 (de)
AU (1) AU706223B2 (de)
CA (1) CA2194153C (de)
DE (1) DE69518984T2 (de)
WO (1) WO1996000797A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948256A4 (de) * 1996-10-28 2007-10-24 Univ Washington Induktion viraler mutationen durch einführung fehlkodierter ribonukleosid-analoga in viralen rns
US6887707B2 (en) * 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
US6712453B2 (en) * 1997-07-15 2004-03-30 Silverbrook Research Pty Ltd. Ink jet nozzle rim
JP2003500070A (ja) * 1999-05-21 2003-01-07 インビトロゲン・コーポレーション 核酸分子を標識するための組成物および方法
US20020061896A1 (en) * 1999-12-30 2002-05-23 Arshad Siddiqul Imidazopyrimidine nucleoside analogues with anti-HIV activity
US7601489B2 (en) * 2002-03-12 2009-10-13 The Johns Hopkins University Manganese ion regulation of reverse transcriptase activity and methods of modulating same
US20070042352A1 (en) * 2003-08-18 2007-02-22 Dawn Patricia Wooley Retroviral vector and cell-based assay for measuring the mutations rate of retroviruses employing same
US9283242B2 (en) 2013-01-22 2016-03-15 Massachusetts Institute Of Technology Uses of dihydro bases
US10550419B2 (en) * 2013-03-13 2020-02-04 Heidi Kay Utilities of stimulated whole blood culture systems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072574A (en) * 1976-07-30 1978-02-07 The Institute For Cancer Research System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
US5571666A (en) * 1988-10-28 1996-11-05 Oklahoma Medical Research Foundation Thiazine dyes used to inactivate HIV in biological fluids
US5192764A (en) * 1991-05-30 1993-03-09 Research Foundation Of State Of N.Y. Pyrazinone n-oxide nucleosides and analogs thereof
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents

Also Published As

Publication number Publication date
EP0767842A1 (de) 1997-04-16
EP1004675A3 (de) 2000-09-20
DE69518984T2 (de) 2001-03-15
DE69518984D1 (de) 2000-11-02
JP4231550B2 (ja) 2009-03-04
US5512431A (en) 1996-04-30
JP2010068809A (ja) 2010-04-02
EP1004675A2 (de) 2000-05-31
JP2006176534A (ja) 2006-07-06
WO1996000797A1 (en) 1996-01-11
JPH10508183A (ja) 1998-08-18
AU706223B2 (en) 1999-06-10
US6132776A (en) 2000-10-17
CA2194153A1 (en) 1996-01-11
EP0767842B1 (de) 2000-09-27
AU2947595A (en) 1996-01-25
CA2194153C (en) 2003-03-18

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