ATE195878T1 - Toxine und toxoide von clostridium difficile als schleimhautadjuvans - Google Patents

Toxine und toxoide von clostridium difficile als schleimhautadjuvans

Info

Publication number
ATE195878T1
ATE195878T1 AT96923569T AT96923569T ATE195878T1 AT E195878 T1 ATE195878 T1 AT E195878T1 AT 96923569 T AT96923569 T AT 96923569T AT 96923569 T AT96923569 T AT 96923569T AT E195878 T1 ATE195878 T1 AT E195878T1
Authority
AT
Austria
Prior art keywords
toxoids
toxins
clostridium difficile
adjuvant
mucous
Prior art date
Application number
AT96923569T
Other languages
German (de)
English (en)
Inventor
William D Thomas Jr
Thomas P Monath
Zhenxi Zhang
Francisco Javier Torres-Lopez
Wende Lei
David M Lyerly
James S Moncrief
Original Assignee
Oravax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27053134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE195878(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/543,708 external-priority patent/US5919463A/en
Application filed by Oravax Inc filed Critical Oravax Inc
Application granted granted Critical
Publication of ATE195878T1 publication Critical patent/ATE195878T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT96923569T 1995-07-07 1996-07-01 Toxine und toxoide von clostridium difficile als schleimhautadjuvans ATE195878T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49938495A 1995-07-07 1995-07-07
US08/543,708 US5919463A (en) 1995-07-07 1995-10-16 Clostridium difficle toxins as mucosal adjuvants
PCT/US1996/011142 WO1997002836A1 (en) 1995-07-07 1996-07-01 Clostridium difficile toxins as mucosal adjuvants

Publications (1)

Publication Number Publication Date
ATE195878T1 true ATE195878T1 (de) 2000-09-15

Family

ID=27053134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923569T ATE195878T1 (de) 1995-07-07 1996-07-01 Toxine und toxoide von clostridium difficile als schleimhautadjuvans

Country Status (9)

Country Link
EP (1) EP0837692B1 (enExample)
JP (1) JPH11509200A (enExample)
CN (1) CN1195297A (enExample)
AT (1) ATE195878T1 (enExample)
AU (1) AU720567B2 (enExample)
CA (1) CA2226339A1 (enExample)
DE (1) DE69610106D1 (enExample)
NZ (1) NZ312502A (enExample)
WO (1) WO1997002836A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9626864D0 (en) * 1996-12-24 1997-02-12 Smithkline Beecham Biolog Vaccine
AU746859B2 (en) * 1997-06-20 2002-05-02 Imperial College Of Science, Technology And Medicine Immonogenic fragments of toxin a of clostridium difficile
US6969520B2 (en) 1997-10-20 2005-11-29 Acambis Inc. Active immunization against clostridium difficile disease
US6214341B1 (en) 1997-10-20 2001-04-10 Oravax Passive immunization against Clostridium difficile disease
EP1568378B1 (en) * 1997-10-20 2016-03-16 Sanofi Pasteur Biologics, LLC Immunization against Clostridium difficile disease
AU6524798A (en) * 1998-03-31 1999-10-18 Dae Woong Pharmaceutical Co., Ltd. A preventive and therapeutic vaccine for (helicobacter pylori)-associated diseases
EP1165796A2 (en) * 1999-04-09 2002-01-02 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
US6733760B1 (en) 1999-04-09 2004-05-11 Techlab, Inc. Recombinant toxin A/toxin B vaccine against Clostridium difficile
WO2000061762A1 (en) * 1999-04-09 2000-10-19 Techlab, Inc. RECOMBINANT TOXIN A/TOXIN B VACCINE AGAINST $i(CLOSTRIDIUM DIFFICILE)
AU2011238711B2 (en) 2010-03-30 2015-06-18 Pelican Technology Holdings, Inc. High level expression of recombinant toxin proteins
CN103957931B (zh) 2010-09-03 2017-10-24 瓦尔内瓦奥地利有限责任公司 艰难梭状芽胞杆菌毒素a和毒素b蛋白的分离多肽及其用途
SI3505531T1 (sl) 2011-04-22 2024-02-29 Wyeth Llc Kompozicije, povezane z mutantnim toksinom clostridium difficile in njegovimii metodami
CN103732750A (zh) * 2011-05-27 2014-04-16 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
MX2014006630A (es) 2011-12-08 2014-07-09 Novartis Ag Vacuna a base toxina clostridium difficile.
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4944942A (en) * 1987-08-27 1990-07-31 Mobay Corporation Intranasal vaccination of horses with inactivated microorganisms or antigenic material
JP2849632B2 (ja) * 1988-04-08 1999-01-20 社団法人北里研究所 ワクチン製剤
US5601823A (en) * 1989-10-31 1997-02-11 Ophidian Pharmaceuticals, Inc. Avian antitoxins to clostridium difficle toxin A
IL106362A (en) * 1992-07-16 1998-12-06 Oxford University A system for launching multiple particle antigens
GB9305919D0 (en) * 1993-03-22 1993-05-12 Health Lab Service Board Botulinum toxin polypeptides and their use as vaccines

Also Published As

Publication number Publication date
DE69610106D1 (de) 2000-10-05
CA2226339A1 (en) 1997-01-30
AU6404796A (en) 1997-02-10
EP0837692A4 (enExample) 1998-04-29
AU720567B2 (en) 2000-06-08
CN1195297A (zh) 1998-10-07
EP0837692A1 (en) 1998-04-29
JPH11509200A (ja) 1999-08-17
EP0837692B1 (en) 2000-08-30
NZ312502A (en) 1999-03-29
WO1997002836A1 (en) 1997-01-30

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