ATE193827T1 - Verwendung von 1-2-4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren - Google Patents

Verwendung von 1-2-4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren

Info

Publication number
ATE193827T1
ATE193827T1 AT94202693T AT94202693T ATE193827T1 AT E193827 T1 ATE193827 T1 AT E193827T1 AT 94202693 T AT94202693 T AT 94202693T AT 94202693 T AT94202693 T AT 94202693T AT E193827 T1 ATE193827 T1 AT E193827T1
Authority
AT
Austria
Prior art keywords
tumors
treatment
administering
production
medicinal product
Prior art date
Application number
AT94202693T
Other languages
English (en)
Inventor
Martin J Brown
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE193827T1 publication Critical patent/ATE193827T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT94202693T 1993-09-22 1994-09-19 Verwendung von 1-2-4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren ATE193827T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/125,609 US5484612A (en) 1993-09-22 1993-09-22 Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

Publications (1)

Publication Number Publication Date
ATE193827T1 true ATE193827T1 (de) 2000-06-15

Family

ID=22420569

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99118533T ATE270553T1 (de) 1993-09-22 1994-09-19 Anwendung von 1,2,4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren
AT94202693T ATE193827T1 (de) 1993-09-22 1994-09-19 Verwendung von 1-2-4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99118533T ATE270553T1 (de) 1993-09-22 1994-09-19 Anwendung von 1,2,4-benzotriazinoxiden zur herstellung eines arzneimittels zur behandlung von tumoren

Country Status (22)

Country Link
US (4) US5484612A (de)
EP (2) EP0649658B1 (de)
JP (1) JPH07215882A (de)
KR (1) KR100383402B1 (de)
AT (2) ATE270553T1 (de)
AU (1) AU690132B2 (de)
CA (1) CA2132578C (de)
CZ (1) CZ289742B6 (de)
DE (2) DE69433889T2 (de)
DK (2) DK0972517T3 (de)
ES (2) ES2147567T3 (de)
GR (1) GR3034360T3 (de)
HU (1) HUT71119A (de)
IL (1) IL111025A (de)
MY (1) MY112405A (de)
NO (1) NO943524L (de)
NZ (2) NZ264502A (de)
PT (2) PT649658E (de)
RU (1) RU2148406C1 (de)
SG (1) SG52568A1 (de)
SK (1) SK282178B6 (de)
UA (1) UA49787C2 (de)

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US5597582A (en) * 1995-09-12 1997-01-28 Sanofi Oral gel capsule formulation of 1,2,4-benzotriazine oxides
US5672702A (en) * 1995-12-04 1997-09-30 Sanofi Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
WO1998039009A1 (en) * 1997-03-07 1998-09-11 Sanofi Pharmaceuticals, Inc. Method of treating a tumor
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
DE69841058D1 (de) * 1997-11-14 2009-09-24 Gen Hospital Corp Behandlung von hämatologischen störungen
US6074626A (en) * 1998-03-20 2000-06-13 Molecular Radiation Management, Inc. Radioactive cisplatin in the treatment of cancer
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US6819761B1 (en) * 1999-09-16 2004-11-16 Silicon Laboratories, Inc. Programmable constant current “off hook” circuit
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1254122B1 (de) 1999-12-21 2008-09-17 UFZ-UMWELTFORSCHUNGSZENTRUM Leipzig-Halle GmbH Neue 3-substituierte 1,2,4-benzotriazine, verfahren zu ihrer herstellung und ihre verwendung zur behandlung und prophylaxe von tumorerkrankungen
US6989139B2 (en) * 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
AUPQ641100A0 (en) * 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
CA2307278A1 (en) * 2000-04-28 2001-10-28 University Of British Columbia Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
RU2166945C1 (ru) * 2000-08-08 2001-05-20 Ефимова Лариса Степановна Радиосенсибилизирующее вещество для лечения онкологических заболеваний
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
RU2192862C1 (ru) * 2001-05-23 2002-11-20 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Способ лечения больших и мультицентричных ретинобластом
AT412703B (de) 2001-12-04 2005-06-27 Vis Vitalis Lizenz & Handels Verwendung von selenithältigen präparaten zur topischen oder bukkalen anwendung
NZ521436A (en) * 2002-09-17 2005-07-29 Auckland Uniservices Ltd DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy
RU2234916C2 (ru) * 2002-10-29 2004-08-27 Московский областной научно-исследовательский клинический институт Способ лечения онкологических больных
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
CA2456569A1 (en) * 2003-03-14 2004-09-14 Auckland Uniservices Limited Benzoazine mono-n-oxides and benzoazine 1,4 dioxides and compositions therefrom for the therapeutic use in cancer treatments
RU2243766C1 (ru) * 2003-04-01 2005-01-10 Ростовский научно-исследовательский онкологический институт МЗ РФ Способ лечения рецидивов рака шейки матки
WO2005082867A1 (en) * 2004-03-01 2005-09-09 Auckland Uniservices Limited Novel 1,2,4-benzotriazine-1,4-dioxides
AU2006229566B2 (en) * 2005-03-31 2011-12-22 Auckland Uniservices Limited Tricyclic 1,2,4-triazine oxides and compositions therefrom for therapeutic use in cancer treatments
US20090136521A1 (en) * 2005-10-03 2009-05-28 Genetix Pharmaceuticals , Inc. Method for Selectively Depleting Hypoxic Cells
US20070212360A1 (en) * 2006-01-17 2007-09-13 Denko Nicholas C Modulation of mitochondrial oxygen consumption for therapeutic purposes
US7834178B2 (en) * 2006-03-01 2010-11-16 Bristol-Myers Squibb Company Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors
US20090117203A1 (en) * 2006-03-23 2009-05-07 Tmrc Co., Ltd. Kit for cancer treatment and pharmaceutical composition for cancer treatment
EP2244662B1 (de) * 2008-01-28 2021-09-29 Implantica Patent Ltd. Vorrichtung und system zur entfernung eines blutgerinnsels
KR101925436B1 (ko) 2008-04-10 2018-12-05 버지니아 커먼웰스 유니버시티 암 치료를 위한 종양 저 산소 상태의 유도
US9316632B2 (en) * 2009-03-17 2016-04-19 Marshall University Research Corporation Methods of screening chemotherapeutic agents and treating cancer
AT511159A1 (de) 2011-02-16 2012-09-15 Selo Medical Gmbh Pharmazeutische zusammensetzungen enthaltend selenit- oder selenathältige verbindungen
WO2013086467A1 (en) * 2011-12-07 2013-06-13 Sri International Benzotriazine oxides as drugs targeting mycobacterium tuberculosis
CA2880896C (en) 2012-06-26 2021-11-16 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
CA3130291A1 (en) 2019-03-27 2020-10-01 Anthony P. FORD Beta adrenergic agonist and methods of using the same
EP3993878A4 (de) * 2019-07-01 2023-11-08 Curasen Therapeutics, Inc. Beta-adrenerger agonist und verfahren zu seiner verwendung

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US4001410A (en) * 1972-02-01 1977-01-04 Bayer Aktiengesellschaft 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
US4923878A (en) * 1988-11-14 1990-05-08 Merck & Co., Inc. Quinolizine sulfonamides used against certain neoplastic disease states
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
US5597582A (en) * 1995-09-12 1997-01-28 Sanofi Oral gel capsule formulation of 1,2,4-benzotriazine oxides

Also Published As

Publication number Publication date
DE69433889D1 (de) 2004-08-12
NO943524L (no) 1995-03-23
MY112405A (en) 2001-06-30
JPH07215882A (ja) 1995-08-15
US6277835B1 (en) 2001-08-21
SK114894A3 (en) 1995-11-08
EP0972517A3 (de) 2000-01-26
UA49787C2 (uk) 2002-10-15
EP0972517A2 (de) 2000-01-19
US5484612A (en) 1996-01-16
CA2132578C (en) 1998-10-13
ATE270553T1 (de) 2004-07-15
EP0972517B1 (de) 2004-07-07
SG52568A1 (en) 1998-09-28
ES2147567T3 (es) 2000-09-16
NZ299690A (en) 1997-11-24
US5670502A (en) 1997-09-23
CA2132578A1 (en) 1995-03-23
SK282178B6 (sk) 2001-11-06
CZ232694A3 (en) 1995-09-13
NZ264502A (en) 1997-06-24
PT972517E (pt) 2004-11-30
US6121263A (en) 2000-09-19
DE69424915T2 (de) 2001-01-18
IL111025A0 (en) 1994-11-28
PT649658E (pt) 2000-12-29
DE69433889T2 (de) 2005-06-30
KR950007853A (ko) 1995-04-15
ES2224517T3 (es) 2005-03-01
GR3034360T3 (en) 2000-12-29
IL111025A (en) 2006-04-10
KR100383402B1 (ko) 2003-09-22
HU9402726D0 (en) 1994-12-28
NO943524D0 (no) 1994-09-22
DK0972517T3 (da) 2004-11-08
DE69424915D1 (de) 2000-07-20
EP0649658B1 (de) 2000-06-14
HUT71119A (en) 1995-11-28
DK0649658T3 (da) 2000-09-11
EP0649658A1 (de) 1995-04-26
AU690132B2 (en) 1998-04-23
CZ289742B6 (cs) 2002-03-13
RU94034104A (ru) 1996-11-10
RU2148406C1 (ru) 2000-05-10
AU7411794A (en) 1995-04-06

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee