ATE192498T1 - Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen - Google Patents

Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen

Info

Publication number
ATE192498T1
ATE192498T1 AT90903867T AT90903867T ATE192498T1 AT E192498 T1 ATE192498 T1 AT E192498T1 AT 90903867 T AT90903867 T AT 90903867T AT 90903867 T AT90903867 T AT 90903867T AT E192498 T1 ATE192498 T1 AT E192498T1
Authority
AT
Austria
Prior art keywords
site
gene
lambda
downstream
vector
Prior art date
Application number
AT90903867T
Other languages
English (en)
Inventor
Sarah Jane Eccles
Franklin Gerardus Grosveld
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE192498T1 publication Critical patent/ATE192498T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Image Analysis (AREA)
  • Devices For Executing Special Programs (AREA)
AT90903867T 1989-02-22 1990-02-22 Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen ATE192498T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898904009A GB8904009D0 (en) 1989-02-22 1989-02-22 Vector
PCT/GB1990/000286 WO1990010077A1 (en) 1989-02-22 1990-02-22 Vector for integration site independent gene expression in mammalian host cells

Publications (1)

Publication Number Publication Date
ATE192498T1 true ATE192498T1 (de) 2000-05-15

Family

ID=10652102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90903867T ATE192498T1 (de) 1989-02-22 1990-02-22 Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen

Country Status (10)

Country Link
EP (2) EP0962534A3 (de)
JP (1) JPH04505552A (de)
AT (1) ATE192498T1 (de)
AU (2) AU5161490A (de)
CA (2) CA2297385A1 (de)
DE (1) DE69033531T2 (de)
DK (1) DK0460042T3 (de)
ES (1) ES2150411T3 (de)
GB (1) GB8904009D0 (de)
WO (1) WO1990010077A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027917D0 (en) * 1990-12-21 1991-02-13 Ici Plc Expression systems
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
DE19541450C2 (de) * 1995-11-07 1997-10-02 Gsf Forschungszentrum Umwelt Genkonstrukt und dessen Verwendung
TWI250019B (en) 1998-08-18 2006-03-01 Univ California Preventing airway mucus production by administration of EGF-R antagonists
EP2308974A3 (de) 1999-10-14 2011-08-10 Clontech Laboratories Inc. Aus Anthozoa abgeleitete Chrom-/Fluorproteine sowie Verwendungsverfahren dafür
JP2003000243A (ja) 2001-06-25 2003-01-07 Takachika Azuma 変異体の製造法
DE60233347D1 (de) 2001-12-19 2009-09-24 Univ Chicago Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung
US7585501B2 (en) 2002-06-14 2009-09-08 Stowers Institute For Medical Research Compositions and methods for treating kidney disease
US20070172446A1 (en) 2003-05-16 2007-07-26 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
RS20110578A3 (en) 2003-10-14 2016-02-29 F. Hoffmann-La Roche Ltd MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULPHONAMIDES AS HCV REPLICATION INHIBITORS
US7250298B2 (en) 2004-04-07 2007-07-31 The University Of Chicago Monomeric red fluorescent proteins
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
EP2029157A4 (de) 2006-05-19 2009-11-18 Georgia Tech Res Inst Abc-transporterligand
US8324158B2 (en) 2006-07-14 2012-12-04 Georgia Tech Research Corporation Methods for inhibiting CLC-2 channel with GATX2
WO2008094316A2 (en) 2006-09-22 2008-08-07 Stowers Institute Of Medical Research Novel branchiostoma derived fluorescent proteins
WO2009059305A2 (en) 2007-11-01 2009-05-07 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
EP3025727A1 (de) 2008-10-02 2016-06-01 The J. David Gladstone Institutes Verfahren zur behandlung von lebererkrankungen
JP5827127B2 (ja) 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
PL2482849T3 (pl) 2009-09-30 2018-11-30 Memorial Sloan-Kettering Cancer Center Skojarzona immunoterapia w leczeniu nowotworu
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
US10881084B2 (en) 2010-07-26 2021-01-05 Trianni, Inc Transgenic animals and methods of use
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
PL2967012T3 (pl) 2013-03-14 2021-04-19 Erasmus University Medical Center Rotterdam Transgeniczne ssaki inne niż człowiek do wytwarzania przeciwciał
AU2020299569A1 (en) 2019-07-01 2022-01-20 Trianni, Inc. Transgenic mammals and methods of use
CA3144958A1 (en) 2019-07-01 2021-01-07 Trianni, Inc. Transgenic mammals and methods of use thereof
CN111424054B (zh) * 2020-04-21 2021-08-27 鲲石生物科技(深圳)有限公司 改进的大型载体在人类细胞中传递方法的发现及应用
CN114763558B (zh) 2021-01-14 2024-02-20 上海泰槿生物技术有限公司 重组基因组、非人哺乳动物细胞及其产生方法和用途
CA3216988A1 (en) 2021-05-05 2022-11-10 Werner Mueller Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof
CN118265449A (zh) 2021-11-10 2024-06-28 特里安尼公司 转基因哺乳动物及其使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005083A1 (en) * 1986-12-24 1988-07-14 Whitehead Institute For Biomedical Research Method of inducible gene expression
DE3724482C2 (de) * 1987-07-24 1995-12-14 Boehringer Mannheim Gmbh Verfahren zur Erweiterung der Zellspezifität von eukaryotischen Expressionsvektoren

Also Published As

Publication number Publication date
DE69033531T2 (de) 2001-01-11
AU5161490A (en) 1990-09-26
AU672910B2 (en) 1996-10-17
EP0460042A1 (de) 1991-12-11
DK0460042T3 (da) 2000-07-31
EP0962534A3 (de) 1999-12-22
DE69033531D1 (de) 2000-06-08
EP0962534A2 (de) 1999-12-08
JPH04505552A (ja) 1992-10-01
CA2297385A1 (en) 1990-08-23
GB8904009D0 (en) 1989-04-05
EP0460042B1 (de) 2000-05-03
ES2150411T3 (es) 2000-12-01
WO1990010077A1 (en) 1990-09-07
AU6872694A (en) 1994-11-17
CA2050920A1 (en) 1990-08-23

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UEP Publication of translation of european patent specification
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