ATE189685T1 - Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität - Google Patents
Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivitätInfo
- Publication number
- ATE189685T1 ATE189685T1 AT97303251T AT97303251T ATE189685T1 AT E189685 T1 ATE189685 T1 AT E189685T1 AT 97303251 T AT97303251 T AT 97303251T AT 97303251 T AT97303251 T AT 97303251T AT E189685 T1 ATE189685 T1 AT E189685T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- lysine
- group
- ornithine
- cyclic
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000002496 gastric effect Effects 0.000 title abstract 2
- 230000004936 stimulating effect Effects 0.000 title abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 8
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 8
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 4
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 4
- OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 abstract 4
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 4
- 229960005261 aspartic acid Drugs 0.000 abstract 4
- 229960002989 glutamic acid Drugs 0.000 abstract 4
- 229960003104 ornithine Drugs 0.000 abstract 4
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- 229930028154 D-arginine Natural products 0.000 abstract 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-Lysine Natural products NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 235000019766 L-Lysine Nutrition 0.000 abstract 1
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- 229930182816 L-glutamine Chemical group 0.000 abstract 1
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960003767 alanine Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/63—Motilins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/648,644 US5734012A (en) | 1996-05-16 | 1996-05-16 | Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189685T1 true ATE189685T1 (de) | 2000-02-15 |
Family
ID=24601620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97303251T ATE189685T1 (de) | 1996-05-16 | 1997-05-13 | Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5734012A (de) |
| EP (1) | EP0807639B1 (de) |
| JP (1) | JPH1053599A (de) |
| KR (1) | KR970073603A (de) |
| AT (1) | ATE189685T1 (de) |
| CA (1) | CA2200935C (de) |
| DE (1) | DE69701269T2 (de) |
| ES (1) | ES2144826T3 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265495B1 (en) | 1998-09-22 | 2001-07-24 | Nippon Shokubai Co., Ltd. | Method for production of esterified product |
| CA2528375C (en) | 2003-06-18 | 2013-11-19 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor |
| US20060287243A1 (en) * | 2005-06-17 | 2006-12-21 | Navneet Puri | Stable pharmaceutical compositions including motilin-like peptides |
| US20060293243A1 (en) * | 2005-06-17 | 2006-12-28 | Navneet Puri | Stable, buffered, pharmaceutical compositions including motilin-like peptides |
| EP1902022A1 (de) | 2005-07-12 | 2008-03-26 | Glaxo Group Limited | Piperazinheteroarylderivate als gpr38-agonisten |
| MY150098A (en) * | 2005-07-26 | 2013-11-29 | Glaxo Group Ltd | Benzylpiperazine derivates and their medical use |
| EP2431380A3 (de) | 2006-09-11 | 2013-07-03 | Tranzyme Pharma, Inc. | Makrozyklischer Antagonist des Motilinrezeptors zur Behandlung von Magen-Darm-Motilitätsstörungen |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| EP2401268B1 (de) | 2009-02-27 | 2015-07-29 | RaQualia Pharma Inc | Oxyindol-derivate mit motilinrezeptor-agonisten-aktivität |
| CN105294732B (zh) * | 2009-08-05 | 2018-09-25 | 波利弗尔股份公司 | 构象受限的完全合成的大环化合物 |
| JP5727479B2 (ja) | 2009-08-05 | 2015-06-03 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | コンホメーションを固定された、合成マクロ環化合物 |
| TWI662967B (zh) * | 2013-03-25 | 2019-06-21 | 日商志瑞亞新藥工業股份有限公司 | 食後期之胃運動亢進劑 |
| CN104861045A (zh) * | 2014-02-20 | 2015-08-26 | 复旦大学 | 环肽化合物gg6f及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084442A (en) * | 1988-09-06 | 1992-01-28 | Hoffmann-La Roche Inc. | Cyclic growth hormone releasing factor analogs and method for the manufacture thereof |
| EP0378078A1 (de) * | 1989-01-06 | 1990-07-18 | Sanwa Kagaku Kenkyusho Co., Ltd. | Dem Motilin ähnliches Polypeptid und seine Verwendung |
| US5470830A (en) * | 1993-08-06 | 1995-11-28 | Ohmeda Pharmaceutical Products Division Inc. | Motilin-like polypeptides that inhibit gastrointestinal motor activity |
| US5422341A (en) * | 1993-08-06 | 1995-06-06 | Ohmeda Pharmaceutical Products Division Inc. | Motilin-like polypeptides with gastrointestinal motor stimulating activity |
-
1996
- 1996-05-16 US US08/648,644 patent/US5734012A/en not_active Expired - Lifetime
-
1997
- 1997-03-25 CA CA002200935A patent/CA2200935C/en not_active Expired - Fee Related
- 1997-05-13 EP EP97303251A patent/EP0807639B1/de not_active Expired - Lifetime
- 1997-05-13 ES ES97303251T patent/ES2144826T3/es not_active Expired - Lifetime
- 1997-05-13 AT AT97303251T patent/ATE189685T1/de not_active IP Right Cessation
- 1997-05-13 DE DE69701269T patent/DE69701269T2/de not_active Expired - Fee Related
- 1997-05-16 JP JP9126736A patent/JPH1053599A/ja not_active Abandoned
- 1997-05-16 KR KR1019970018893A patent/KR970073603A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US5734012A (en) | 1998-03-31 |
| DE69701269D1 (de) | 2000-03-16 |
| CA2200935A1 (en) | 1997-11-16 |
| EP0807639A3 (de) | 1997-11-26 |
| KR970073603A (ko) | 1997-12-10 |
| CA2200935C (en) | 2005-05-24 |
| EP0807639B1 (de) | 2000-02-09 |
| JPH1053599A (ja) | 1998-02-24 |
| DE69701269T2 (de) | 2000-09-14 |
| ES2144826T3 (es) | 2000-06-16 |
| EP0807639A2 (de) | 1997-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |