ATE185842T1 - Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien - Google Patents
Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzienInfo
- Publication number
- ATE185842T1 ATE185842T1 AT95927686T AT95927686T ATE185842T1 AT E185842 T1 ATE185842 T1 AT E185842T1 AT 95927686 T AT95927686 T AT 95927686T AT 95927686 T AT95927686 T AT 95927686T AT E185842 T1 ATE185842 T1 AT E185842T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- lactams
- highly concentrated
- producing beta
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK85394 | 1994-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE185842T1 true ATE185842T1 (de) | 1999-11-15 |
Family
ID=8098286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95927686T ATE185842T1 (de) | 1994-07-18 | 1995-07-18 | Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien |
Country Status (9)
Country | Link |
---|---|
US (1) | US6048708A (de) |
EP (1) | EP0771357B1 (de) |
CN (1) | CN1095875C (de) |
AT (1) | ATE185842T1 (de) |
AU (1) | AU3163295A (de) |
DE (1) | DE69512917D1 (de) |
ES (1) | ES2139923T3 (de) |
MX (1) | MX9700565A (de) |
WO (1) | WO1996002663A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW555855B (en) * | 1996-07-26 | 2003-10-01 | Bristol Myers Squibb Co | Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
NL1006266C2 (nl) * | 1997-06-10 | 1998-12-14 | Chemferm Vof | Werkwijze voor de bereiding van ampicilline. |
AU8799498A (en) * | 1997-06-10 | 1998-12-30 | Gist-Brocades B.V. | Process for enzymatically preparing a beta-lactam antibiotic and this antibiotic |
NL1007302C2 (nl) * | 1997-10-17 | 1999-04-20 | Dsm Nv | Werkwijze voor de bereiding van een ß-lactam antibioticum. |
DE19823332C2 (de) * | 1998-05-26 | 2000-09-07 | Unifar Kimya Sanayii Ve Ticare | Verfahren zur enzymatischen Herstellung von Betalactam-Antibiotika |
EP1394262A1 (de) * | 2002-08-30 | 2004-03-03 | Bioferma Murcia, S.A. | Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen |
LT1641933T (lt) | 2003-07-03 | 2018-04-10 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Cefradino gamybos būdas |
KR101337798B1 (ko) * | 2005-09-29 | 2013-12-06 | 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. | 유기산의 에스터화 방법 |
ES2609633T3 (es) | 2006-05-19 | 2017-04-21 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Proceso para la cristalización de cefadroxilo monohidrato |
KR20100072171A (ko) * | 2007-07-27 | 2010-06-30 | 페르멘타 바이오테크 리미티드 | 이. 콜라이 bl 21 ccm 7394에서 발현된 아크로모박터 종 ccm 4824 유래의 고정화된 재조합 페니실린 아실라아제 촉매의 제조방법 및 베타-락탐 항생제의 합성을 위한 이의 용도 |
CN101525603B (zh) * | 2008-03-04 | 2013-12-25 | 中国医药集团总公司四川抗菌素工业研究所 | 固定化α-氨基酸酯水解酶及其制备与应用 |
WO2010147957A2 (en) | 2009-06-15 | 2010-12-23 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
WO2011113486A1 (en) | 2010-03-17 | 2011-09-22 | Deretil, S.A. | Process for the synthesis of hydroxyphenylglycine esters |
WO2012175585A1 (en) | 2011-06-23 | 2012-12-27 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase |
CN103635586A (zh) | 2011-06-23 | 2014-03-12 | 中化帝斯曼制药有限公司荷兰公司 | 结晶头孢氧哌唑中间体、其制备方法及其制药用途 |
US9695244B2 (en) | 2012-06-01 | 2017-07-04 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
CN105153197B (zh) * | 2015-07-28 | 2017-05-31 | 齐鲁安替制药有限公司 | 一种头孢中间体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5231436B2 (de) * | 1971-08-20 | 1977-08-15 | ||
DK198789A (da) * | 1988-04-26 | 1989-10-27 | Gist Brocades Nv | Fremgangsmaade til enzymatisk fremstilling af beta-lactamer |
US5334497A (en) * | 1988-12-13 | 1994-08-02 | Hideki Inaba | Method of feeding a substrate into tubular bioreactor |
ES2036149A6 (es) * | 1989-12-12 | 1993-05-01 | Consejo Superior Investigacion | Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. |
EP0537255B1 (de) * | 1990-07-04 | 2006-02-15 | DSM IP Assets B.V. | Verfahren zur herstellung von beta-lactamen |
-
1995
- 1995-07-18 WO PCT/EP1995/002876 patent/WO1996002663A1/en active IP Right Grant
- 1995-07-18 DE DE69512917T patent/DE69512917D1/de not_active Expired - Lifetime
- 1995-07-18 MX MX9700565A patent/MX9700565A/es not_active IP Right Cessation
- 1995-07-18 US US08/776,115 patent/US6048708A/en not_active Expired - Lifetime
- 1995-07-18 AU AU31632/95A patent/AU3163295A/en not_active Abandoned
- 1995-07-18 ES ES95927686T patent/ES2139923T3/es not_active Expired - Lifetime
- 1995-07-18 EP EP95927686A patent/EP0771357B1/de not_active Expired - Lifetime
- 1995-07-18 AT AT95927686T patent/ATE185842T1/de active
- 1995-07-18 CN CN95194209A patent/CN1095875C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1996002663A1 (en) | 1996-02-01 |
US6048708A (en) | 2000-04-11 |
CN1152945A (zh) | 1997-06-25 |
AU3163295A (en) | 1996-02-16 |
EP0771357B1 (de) | 1999-10-20 |
ES2139923T3 (es) | 2000-02-16 |
EP0771357A1 (de) | 1997-05-07 |
MX9700565A (es) | 1997-05-31 |
DE69512917D1 (de) | 1999-11-25 |
CN1095875C (zh) | 2002-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner |