ATE180773T1 - N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren - Google Patents
N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptorenInfo
- Publication number
- ATE180773T1 ATE180773T1 AT93904135T AT93904135T ATE180773T1 AT E180773 T1 ATE180773 T1 AT E180773T1 AT 93904135 T AT93904135 T AT 93904135T AT 93904135 T AT93904135 T AT 93904135T AT E180773 T1 ATE180773 T1 AT E180773T1
- Authority
- AT
- Austria
- Prior art keywords
- vasopressin
- affinity
- sulfonyl
- derivatives
- ocytocin receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- C07D209/92—Naphthostyrils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9201034A FR2686878B1 (fr) | 1992-01-30 | 1992-01-30 | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180773T1 true ATE180773T1 (de) | 1999-06-15 |
Family
ID=9426168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93904135T ATE180773T1 (de) | 1992-01-30 | 1993-01-28 | N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0581939B1 (member.php) |
| JP (1) | JPH06507182A (member.php) |
| AT (1) | ATE180773T1 (member.php) |
| AU (1) | AU662960B2 (member.php) |
| BR (1) | BR9303993A (member.php) |
| CA (1) | CA2107348A1 (member.php) |
| CZ (1) | CZ203793A3 (member.php) |
| DE (1) | DE69325130D1 (member.php) |
| FI (2) | FI980341A0 (member.php) |
| FR (1) | FR2686878B1 (member.php) |
| HU (1) | HUT68642A (member.php) |
| IL (1) | IL104559A0 (member.php) |
| MX (1) | MX9300498A (member.php) |
| NO (1) | NO180538C (member.php) |
| NZ (1) | NZ249158A (member.php) |
| RU (1) | RU2135469C1 (member.php) |
| SK (1) | SK105393A3 (member.php) |
| TW (1) | TW239126B (member.php) |
| WO (1) | WO1993015051A1 (member.php) |
| ZA (1) | ZA93649B (member.php) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2708608B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant. |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
| FR2722190B1 (fr) * | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
| AU5772196A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| FR2740136B1 (fr) * | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
| US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO2001005790A1 (en) | 1999-07-21 | 2001-01-25 | Astrazeneca Ab | New compounds |
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| DE10222034A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Tetrahydroisochinolin-Derivate |
| CN100378108C (zh) * | 2002-06-21 | 2008-04-02 | 苏文生命科学有限公司 | 对血清素受体具有亲和力、可用作治疗剂的新型四环芳基磺酰吲哚、其制备方法及其药物组合物 |
| RU2259999C2 (ru) * | 2003-08-26 | 2005-09-10 | ООО "Исследовательский институт химического разнообразия" | 1-сульфонил-1,3-дигидроиндол-2-оны, фармацевтические композиции (варианты), способ их получения и применения |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US20050070718A1 (en) | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| CA2593044A1 (en) * | 2004-12-31 | 2006-07-13 | Abbott Gmbh & Co. Kg | Substituted oxindole derivatives, medicaments containing said derivatives and use thereof |
| WO2006080574A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | １，３－ジヒドロ－２ｈ－インドール－２－オン化合物、及び芳香族複素環が縮合したピロリジン－２－オン化合物 |
| DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
| DE102005015957A1 (de) * | 2005-03-31 | 2006-10-05 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
| DE102005014936A1 (de) | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
| US7803834B2 (en) | 2005-03-24 | 2010-09-28 | Abbott Gmbh & Co. Kg | Substituted oxindole derivatives, drugs containing said derivatives and the use thereof |
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| WO2007028638A1 (en) | 2005-09-09 | 2007-03-15 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
| CN101336239A (zh) | 2005-12-02 | 2008-12-31 | 艾博特股份有限两合公司 | 经取代的羟吲哚衍生物，含有该衍生物的药物及其用途 |
| EP2061769A1 (en) | 2006-08-26 | 2009-05-27 | Abbott GmbH & Co. KG | Substituted benzimidazolone derivatives, medicaments comprising them and their use |
| DE102006040915A1 (de) | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
| EP2076517A1 (en) * | 2006-09-22 | 2009-07-08 | Janssen Pharmaceutica N.V. | Spiro benzazepines as vasopressin antagonists |
| US7825110B2 (en) * | 2006-09-22 | 2010-11-02 | Janssen Pharmaceutica Nv | Substituted spiroheterocycles |
| ATE545416T1 (de) | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| FR2909668B1 (fr) * | 2006-12-12 | 2009-01-23 | Sanofi Aventis Sa | Derives de 5-alkyloxy-indolin-2-one,leur preparation et leurs applications en therapeutique |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| BRPI0820668A2 (pt) | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
| US8703774B2 (en) | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
| EP2231644B1 (de) | 2007-12-07 | 2014-01-15 | AbbVie Deutschland GmbH & Co KG | 5,6-Disubstitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen |
| MX2010006202A (es) | 2007-12-07 | 2011-03-04 | Abbott Gmbh & Co Kg | Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
| RU2487872C2 (ru) * | 2007-12-27 | 2013-07-20 | Эбботт Гмбх Унд Ко.Кг | Замещенные производные оксиндола и их применение для лечения заболеваний, зависимых от вазопрессина |
| FR2927625B1 (fr) | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
| FR2930249B1 (fr) * | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| BRPI0920448A2 (pt) | 2008-10-17 | 2018-10-23 | Xenon Pharmaceuticals Inc. | compostos spiro-oxindol e seu uso como agentes terapêuticos |
| US9040568B2 (en) | 2009-05-29 | 2015-05-26 | Abbvie Inc. | Pharmaceutical compositions for the treatment of pain |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| RU2544852C2 (ru) | 2009-10-14 | 2015-03-20 | Ксенон Фармасьютикалз Инк. | Способы синтеза спиро-оксиндольных соединений |
| PE20121699A1 (es) | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
| EP2881391A1 (en) | 2013-12-05 | 2015-06-10 | Bayer Pharma Aktiengesellschaft | Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof |
| WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| ES2985738T3 (es) * | 2016-01-20 | 2024-11-07 | Chemocentryx Inc | Compuestos de 2-oxindol |
| CN114702448A (zh) * | 2021-09-30 | 2022-07-05 | 西南大学 | 环烯烃的三氟甲基化串联环化螺环化合物的合成方法 |
| CN119019312B (zh) * | 2024-10-24 | 2025-01-28 | 苏州宜联生物医药有限公司 | 一种吲哚-2-酮衍生物、其抗体药物偶联物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2540057A (en) | 1947-07-02 | 1951-01-30 | Gen Aniline & Film Corp | Aromatic and heterocyclic diazosulfones |
| US3838167A (en) * | 1972-08-01 | 1974-09-24 | Lilly Co Eli | Process for preparing indoles |
| DK167393B1 (da) | 1985-12-30 | 1993-10-25 | Roussel Uclaf | 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf |
| US4863437A (en) * | 1986-03-20 | 1989-09-05 | Clarke Ellis W | Means for fluid administration |
| US4803217A (en) * | 1986-12-24 | 1989-02-07 | Merck & Co., Inc. | Hapalindolinone compounds as vassopressin antagonists |
| EP0303418A3 (en) * | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituted indolones, useful in the treatment of heart or asthmatic diseases |
| CA2037923C (en) * | 1989-07-25 | 1996-08-06 | Akihiro Kawaguchi | Oxindole derivative |
-
1992
- 1992-01-30 FR FR9201034A patent/FR2686878B1/fr not_active Expired - Fee Related
-
1993
- 1993-01-28 FI FI980341A patent/FI980341A0/fi unknown
- 1993-01-28 BR BR9303993A patent/BR9303993A/pt not_active Application Discontinuation
- 1993-01-28 RU RU93055882A patent/RU2135469C1/ru active
- 1993-01-28 FI FI934274A patent/FI934274L/fi unknown
- 1993-01-28 CA CA002107348A patent/CA2107348A1/en not_active Abandoned
- 1993-01-28 AT AT93904135T patent/ATE180773T1/de not_active IP Right Cessation
- 1993-01-28 HU HU9302762A patent/HUT68642A/hu unknown
- 1993-01-28 JP JP5512992A patent/JPH06507182A/ja active Pending
- 1993-01-28 EP EP93904135A patent/EP0581939B1/fr not_active Expired - Lifetime
- 1993-01-28 NZ NZ249158A patent/NZ249158A/en unknown
- 1993-01-28 CZ CZ932037A patent/CZ203793A3/cs unknown
- 1993-01-28 DE DE69325130T patent/DE69325130D1/de not_active Expired - Lifetime
- 1993-01-28 AU AU35043/93A patent/AU662960B2/en not_active Ceased
- 1993-01-28 SK SK1053-93A patent/SK105393A3/sk unknown
- 1993-01-28 WO PCT/FR1993/000093 patent/WO1993015051A1/fr not_active Ceased
- 1993-01-29 ZA ZA93649A patent/ZA93649B/xx unknown
- 1993-01-29 IL IL104559A patent/IL104559A0/xx unknown
- 1993-01-29 MX MX9300498A patent/MX9300498A/es unknown
- 1993-01-30 TW TW082100691A patent/TW239126B/zh active
- 1993-09-29 NO NO933482A patent/NO180538C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69325130D1 (de) | 1999-07-08 |
| SK105393A3 (en) | 1994-08-10 |
| NZ249158A (en) | 1996-02-27 |
| CA2107348A1 (en) | 1993-07-31 |
| TW239126B (member.php) | 1995-01-21 |
| HU9302762D0 (en) | 1993-12-28 |
| EP0581939A1 (fr) | 1994-02-09 |
| FI980341L (fi) | 1998-02-13 |
| WO1993015051A1 (fr) | 1993-08-05 |
| NO180538B (no) | 1997-01-27 |
| JPH06507182A (ja) | 1994-08-11 |
| HUT68642A (en) | 1995-07-28 |
| IL104559A0 (en) | 1993-05-13 |
| FI980341A7 (fi) | 1998-02-13 |
| AU662960B2 (en) | 1995-09-21 |
| FI934274A7 (fi) | 1993-09-29 |
| BR9303993A (pt) | 1994-08-02 |
| FI980341A0 (fi) | 1998-02-13 |
| NO933482D0 (no) | 1993-09-29 |
| FI934274A0 (fi) | 1993-09-29 |
| RU2135469C1 (ru) | 1999-08-27 |
| NO180538C (no) | 1997-05-07 |
| ZA93649B (en) | 1993-09-02 |
| AU3504393A (en) | 1993-09-01 |
| EP0581939B1 (fr) | 1999-06-02 |
| CZ203793A3 (en) | 1994-04-13 |
| FR2686878B1 (fr) | 1995-06-30 |
| FI934274L (fi) | 1993-09-29 |
| MX9300498A (es) | 1994-07-29 |
| FR2686878A1 (fr) | 1993-08-06 |
| NO933482L (no) | 1993-11-29 |
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