ATE17249T1 - 9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one. - Google Patents

9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one.

Info

Publication number
ATE17249T1
ATE17249T1 AT82301460T AT82301460T ATE17249T1 AT E17249 T1 ATE17249 T1 AT E17249T1 AT 82301460 T AT82301460 T AT 82301460T AT 82301460 T AT82301460 T AT 82301460T AT E17249 T1 ATE17249 T1 AT E17249T1
Authority
AT
Austria
Prior art keywords
carbon atoms
aethyl
undecan
oxa
indolyl
Prior art date
Application number
AT82301460T
Other languages
German (de)
English (en)
Inventor
Robin D Clark
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE17249T1 publication Critical patent/ATE17249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AT82301460T 1981-03-23 1982-03-22 9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one. ATE17249T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/246,459 US4332804A (en) 1981-03-23 1981-03-23 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
EP82301460A EP0061333B1 (en) 1981-03-23 1982-03-22 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones

Publications (1)

Publication Number Publication Date
ATE17249T1 true ATE17249T1 (de) 1986-01-15

Family

ID=22930776

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82301460T ATE17249T1 (de) 1981-03-23 1982-03-22 9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one.

Country Status (19)

Country Link
US (1) US4332804A (forum.php)
EP (1) EP0061333B1 (forum.php)
JP (1) JPS57169485A (forum.php)
KR (1) KR830009094A (forum.php)
AT (1) ATE17249T1 (forum.php)
AU (1) AU557094B2 (forum.php)
BR (1) BR8201589A (forum.php)
DE (1) DE3268225D1 (forum.php)
DK (1) DK129282A (forum.php)
ES (1) ES510649A0 (forum.php)
FI (1) FI820998L (forum.php)
IE (1) IE52652B1 (forum.php)
IL (1) IL65310A (forum.php)
NO (1) NO820937L (forum.php)
NZ (1) NZ200085A (forum.php)
PH (1) PH17233A (forum.php)
PL (1) PL235561A1 (forum.php)
PT (1) PT74626B (forum.php)
ZA (1) ZA821929B (forum.php)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4861880A (en) * 1982-09-20 1989-08-29 Pfizer Inc. 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
CN1443167B (zh) 2000-03-06 2012-07-18 阿卡蒂亚药品公司 用于治疗5-羟色胺相关性疾病的氮杂环化合物
RU2315051C2 (ru) * 2001-12-28 2008-01-20 Акадиа Фармасьютикалз, Инк. Спироазациклические соединения, способ ингибирования активности или активации серотонинового 5-нт2а рецептора, способ лечения болезненного состояния, связанного с серотониновым 5-нт2а рецептором, и их применение
US7538222B2 (en) * 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) * 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
EP1562937A2 (en) * 2002-06-24 2005-08-17 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
PT1587789E (pt) * 2003-01-16 2008-12-16 Acadia Pharm Inc Agonistas inversos selectivos para receptores 2a/2c da serotonina como agentes terapêuticos para doenças neurodegenerativas
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
EP1794126B1 (en) * 2004-09-27 2013-03-20 Acadia Pharmaceuticals Inc. Crystalline form of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide hemi-tartrate
US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
ES2423485T3 (es) 2007-03-19 2013-09-20 Acadia Pharmaceuticals Inc. Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos
NO2200610T3 (forum.php) * 2007-09-21 2018-06-09
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
EP3325444B1 (en) 2015-07-20 2021-07-07 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
PT3377500T (pt) 2015-11-16 2022-11-25 Esteve Pharmaceuticals Sa Compostos de oxadiazaspiro para o tratamento de abuso e adição a drogas
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
WO2018118626A1 (en) 2016-12-20 2018-06-28 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin
MY200894A (en) 2017-10-17 2024-01-22 Esteve Pharmaceuticals Sa Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) * 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US3574204A (en) * 1969-07-03 1971-04-06 Yoshitomi Pharmaceutical Piperidine spiro compounds
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
US3723442A (en) * 1970-12-31 1973-03-27 Yoshitomi Pharmaceutical 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof

Also Published As

Publication number Publication date
EP0061333A1 (en) 1982-09-29
ES8306373A1 (es) 1983-06-01
EP0061333B1 (en) 1986-01-02
PL235561A1 (forum.php) 1982-10-25
PT74626A (en) 1982-04-01
IE820648L (en) 1982-09-23
DK129282A (da) 1982-09-24
JPS57169485A (en) 1982-10-19
AU8176982A (en) 1982-09-30
NZ200085A (en) 1985-07-12
PT74626B (en) 1983-12-19
FI820998A7 (fi) 1982-09-24
IL65310A (en) 1985-03-31
AU557094B2 (en) 1986-12-04
ZA821929B (en) 1983-11-30
KR830009094A (ko) 1983-12-17
DE3268225D1 (de) 1986-02-13
IL65310A0 (en) 1982-05-31
PH17233A (en) 1984-07-03
NO820937L (no) 1982-09-24
BR8201589A (pt) 1983-02-08
FI820998L (fi) 1982-09-24
IE52652B1 (en) 1988-01-06
ES510649A0 (es) 1983-06-01
US4332804A (en) 1982-06-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee