ATE16009T1 - Produktion von 4-chloro-7-(2,3,5-tri-o-benzylbeta-d-arabinofuranosyl)-7h-pyrrolo(2,3-d) pyrimidinderivaten. - Google Patents

Produktion von 4-chloro-7-(2,3,5-tri-o-benzylbeta-d-arabinofuranosyl)-7h-pyrrolo(2,3-d) pyrimidinderivaten.

Info

Publication number
ATE16009T1
ATE16009T1 AT83101511T AT83101511T ATE16009T1 AT E16009 T1 ATE16009 T1 AT E16009T1 AT 83101511 T AT83101511 T AT 83101511T AT 83101511 T AT83101511 T AT 83101511T AT E16009 T1 ATE16009 T1 AT E16009T1
Authority
AT
Austria
Prior art keywords
arabinofuranosyl
pyrrolo
tri
benzylbeta
chloro
Prior art date
Application number
AT83101511T
Other languages
English (en)
Inventor
Philip Daniel Cook
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE16009T1 publication Critical patent/ATE16009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT83101511T 1981-01-29 1982-01-25 Produktion von 4-chloro-7-(2,3,5-tri-o-benzylbeta-d-arabinofuranosyl)-7h-pyrrolo(2,3-d) pyrimidinderivaten. ATE16009T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/229,471 US4352795A (en) 1981-01-29 1981-01-29 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
EP83101511A EP0085440B1 (de) 1981-01-29 1982-01-25 Produktion von 4-Chloro-7-(2,3,5-tri-O-Benzyl-Beta-D-Arabinofuranosyl)-7H-Pyrrolo(2,3-d) Pyrimidinderivaten

Publications (1)

Publication Number Publication Date
ATE16009T1 true ATE16009T1 (de) 1985-10-15

Family

ID=22861384

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83101511T ATE16009T1 (de) 1981-01-29 1982-01-25 Produktion von 4-chloro-7-(2,3,5-tri-o-benzylbeta-d-arabinofuranosyl)-7h-pyrrolo(2,3-d) pyrimidinderivaten.

Country Status (5)

Country Link
US (1) US4352795A (de)
EP (2) EP0057548B1 (de)
JP (1) JPS57144298A (de)
AT (1) ATE16009T1 (de)
DE (1) DE3264465D1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439604A (en) * 1981-01-29 1984-03-27 Warner-Lambert Company 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
US4584369A (en) * 1981-07-31 1986-04-22 Sloan-Kettering Institute For Cancer Research Anti-leukemic beta-glycosyl C-nucleosides
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
FR2574407B1 (fr) * 1984-12-12 1987-06-05 Rhone Poulenc Sante Nouveaux derives de la pyrrolo(2,3-d) pyrimidine, leur preparation et les compositions pharmaceutiques qui les contiennent
US4801698A (en) * 1986-08-15 1989-01-31 Warner-Lambert Company Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
US5721356A (en) * 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
EP1418179A3 (de) * 1990-01-11 2006-03-08 Isis Pharmaceuticals, Inc. Zusammensetzungen und Verfahren zum Detektieren und zur Modulation von RNA Aktivität und Genexpression
US6262241B1 (en) * 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
WO1994024144A2 (en) * 1993-04-19 1994-10-27 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
DE19741715A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741738A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
US9188384B2 (en) 2011-03-31 2015-11-17 Basf Se Dynamically evacuable devices comprising organic aerogels or xerogels
US9310374B2 (en) * 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
AU2016354009B2 (en) 2015-11-09 2021-05-20 R.P. Scherer Technologies, Llc Anti-CD22 antibody-maytansine conjugates and methods of use thereof
CN107011347B (zh) * 2017-04-18 2019-01-18 华东师范大学 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE650411A (de) * 1963-07-12
US3300479A (en) * 1965-08-05 1967-01-24 Upjohn Co Deazapurine riboside cyclic 3', 5'-phosphates and process therefor
US3336289A (en) * 1965-09-20 1967-08-15 Upjohn Co 9-beta-d-ribofuranosyl-7-deazapurine 5'-phosphate esters
US3472838A (en) * 1967-12-01 1969-10-14 Parke Davis & Co 9 - (beta - d - arabinofuranosyl) - 6 - (amidino) purine compounds and methods for their production
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
BE756704A (fr) * 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
GB1386584A (en) 1970-11-16 1975-03-12 Wellcome Found Method of preparation of purine sugar derivatives
GB1562899A (en) 1975-06-17 1980-03-19 Wellcome Found Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof
US4069382A (en) * 1976-05-17 1978-01-17 Parke, Davis & Company 9-(5-O-Acyl-β-D-arabinofuranosyl)adenine compounds
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4048432A (en) * 1976-05-17 1977-09-13 Parke, Davis & Company 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production

Also Published As

Publication number Publication date
EP0057548A2 (de) 1982-08-11
JPS57144298A (en) 1982-09-06
EP0057548A3 (en) 1982-12-22
EP0057548B1 (de) 1985-07-03
EP0085440A1 (de) 1983-08-10
DE3264465D1 (en) 1985-08-08
EP0085440B1 (de) 1985-10-09
US4352795A (en) 1982-10-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee