ATE157362T1 - N-pyridyl carboxamidderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen zusammensetzungen - Google Patents
N-pyridyl carboxamidderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen zusammensetzungenInfo
- Publication number
- ATE157362T1 ATE157362T1 AT95401194T AT95401194T ATE157362T1 AT E157362 T1 ATE157362 T1 AT E157362T1 AT 95401194 T AT95401194 T AT 95401194T AT 95401194 T AT95401194 T AT 95401194T AT E157362 T1 ATE157362 T1 AT E157362T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- substd
- opt
- alkoxy
- production
- Prior art date
Links
- NOCSAAHHSOQRCI-UHFFFAOYSA-N n-pyridin-2-ylformamide Chemical class O=CNC1=CC=CC=N1 NOCSAAHHSOQRCI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical group C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- -1 4-oxoÄ4HÜbenzopyran Natural products 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9406412A FR2720396B1 (fr) | 1994-05-27 | 1994-05-27 | Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157362T1 true ATE157362T1 (de) | 1997-09-15 |
Family
ID=9463548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95401194T ATE157362T1 (de) | 1994-05-27 | 1995-05-23 | N-pyridyl carboxamidderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen zusammensetzungen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5712294A (de) |
| EP (1) | EP0684241B1 (de) |
| JP (1) | JP3048511B2 (de) |
| CN (1) | CN1053904C (de) |
| AT (1) | ATE157362T1 (de) |
| AU (1) | AU683151B2 (de) |
| CA (1) | CA2150162C (de) |
| DE (1) | DE69500597T2 (de) |
| DK (1) | DK0684241T3 (de) |
| ES (1) | ES2107284T3 (de) |
| FI (1) | FI952550A (de) |
| FR (1) | FR2720396B1 (de) |
| GR (1) | GR3024799T3 (de) |
| NO (1) | NO308359B1 (de) |
| NZ (1) | NZ272221A (de) |
| ZA (1) | ZA954314B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316479B1 (en) * | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| JP5278983B2 (ja) * | 1999-11-17 | 2013-09-04 | 塩野義製薬株式会社 | アミド化合物の新規用途 |
| US7429593B2 (en) * | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
| FR2833494B1 (fr) * | 2001-12-19 | 2006-12-15 | Univ Nantes | Utilisation de composes de la famille des benzamides comme agent immunosuppresseur |
| US20080262031A1 (en) * | 2005-02-04 | 2008-10-23 | Ctg Pharma S.R.L. | 4-Aminoquinoline Derivatives as Antimalarials |
| CA2606783C (en) | 2005-05-10 | 2014-03-25 | Incyte Corporation | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
| JP5294874B2 (ja) * | 2005-12-20 | 2013-09-18 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロ環 |
| WO2007095050A2 (en) * | 2006-02-09 | 2007-08-23 | Incyte Corporation | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
| US20080146624A1 (en) * | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| CA2663057C (en) * | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| US20080182882A1 (en) * | 2006-11-08 | 2008-07-31 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| KR20080042290A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리돈 구조를 포함하는 캐스파제 저해제 |
| US8822497B2 (en) | 2007-03-01 | 2014-09-02 | Novartis Ag | PIM kinase inhibitors and methods of their use |
| AU2012202993B2 (en) * | 2007-03-01 | 2015-06-25 | Novartis Ag | Pim kinase inhibitors and methods of their use |
| PT2824100T (pt) | 2008-07-08 | 2018-05-10 | Incyte Holdings Corp | 1,2,5-oxadiazoles como inibidores da indoleamina 2,3-dioxigenase |
| WO2010077734A2 (en) * | 2008-12-09 | 2010-07-08 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
| EP2730561B1 (de) | 2010-04-06 | 2015-10-14 | Nippon Soda Co., Ltd. | Verfahren zur Herstellung stickstoffhaltiger haloalkyl-substituierter Heterozyklen |
| AU2014201036B2 (en) * | 2010-04-06 | 2015-07-16 | Nippon Soda Co., Ltd | Nitrogen-containing heterocyclic compound and method for producing same |
| CN104341330B (zh) * | 2013-08-09 | 2016-09-07 | 四川摩尔生物制药有限公司 | 一种n-甲基-n-(3-甲基苯基)硫代甲酰胺及其用途 |
| CR20160252A (es) | 2013-11-08 | 2016-09-19 | Incyte Holdings Corp | Proceso para la sintesis de un inhibidor de indolamina 2,3-dioxigenasa |
| JP2017525753A (ja) * | 2014-06-06 | 2017-09-07 | フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 免疫調節剤 |
| WO2020054712A1 (ja) * | 2018-09-12 | 2020-03-19 | 日本化薬株式会社 | 有害生物防除剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2876235A (en) * | 1956-12-03 | 1959-03-03 | Searle & Co | Basic amides of 3-thianaphthene carboxylic acid |
| US4203988A (en) | 1975-11-12 | 1980-05-20 | Merck & Co., Inc. | Pyridinyl ureas and pharmaceutical use |
| ES2107434T3 (es) * | 1990-07-10 | 1997-12-01 | Ishihara Sangyo Kaisha | Derivados de diaminotrifluorometilpirimidina, su procedimiento de produccion e inhibidores de a2 fosfolipasa que los contiene. |
| US5260320A (en) * | 1990-07-10 | 1993-11-09 | Ishihara Sangyo Kaisha Ltd. | Diaminotrifluoromethylpyridine compounds and phospholipase A2 inhibitor containing them |
| US5399564A (en) | 1991-09-03 | 1995-03-21 | Dowelanco | N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides |
-
1994
- 1994-05-27 FR FR9406412A patent/FR2720396B1/fr not_active Expired - Fee Related
-
1995
- 1995-05-23 DK DK95401194.6T patent/DK0684241T3/da active
- 1995-05-23 DE DE69500597T patent/DE69500597T2/de not_active Expired - Fee Related
- 1995-05-23 EP EP95401194A patent/EP0684241B1/de not_active Expired - Lifetime
- 1995-05-23 AT AT95401194T patent/ATE157362T1/de not_active IP Right Cessation
- 1995-05-23 ES ES95401194T patent/ES2107284T3/es not_active Expired - Lifetime
- 1995-05-24 FI FI952550A patent/FI952550A/fi unknown
- 1995-05-25 CA CA002150162A patent/CA2150162C/fr not_active Expired - Fee Related
- 1995-05-25 US US08/450,346 patent/US5712294A/en not_active Expired - Fee Related
- 1995-05-25 AU AU20288/95A patent/AU683151B2/en not_active Ceased
- 1995-05-26 NZ NZ272221A patent/NZ272221A/en unknown
- 1995-05-26 NO NO952075A patent/NO308359B1/no not_active IP Right Cessation
- 1995-05-26 ZA ZA954314A patent/ZA954314B/xx unknown
- 1995-05-26 CN CN95105512A patent/CN1053904C/zh not_active Expired - Fee Related
- 1995-05-29 JP JP7130573A patent/JP3048511B2/ja not_active Expired - Lifetime
-
1997
- 1997-03-26 US US08/827,344 patent/US5843947A/en not_active Expired - Fee Related
- 1997-09-19 GR GR970402433T patent/GR3024799T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1121074A (zh) | 1996-04-24 |
| US5843947A (en) | 1998-12-01 |
| FR2720396A1 (fr) | 1995-12-01 |
| FI952550A (fi) | 1995-11-28 |
| DE69500597T2 (de) | 1998-03-26 |
| AU683151B2 (en) | 1997-10-30 |
| DK0684241T3 (da) | 1998-04-06 |
| DE69500597D1 (de) | 1997-10-02 |
| NO952075D0 (no) | 1995-05-26 |
| ES2107284T3 (es) | 1997-11-16 |
| CA2150162C (fr) | 2002-05-14 |
| NZ272221A (en) | 1996-04-26 |
| EP0684241A1 (de) | 1995-11-29 |
| FR2720396B1 (fr) | 1996-06-28 |
| US5712294A (en) | 1998-01-27 |
| CA2150162A1 (fr) | 1995-11-28 |
| AU2028895A (en) | 1995-12-07 |
| FI952550A0 (fi) | 1995-05-24 |
| ZA954314B (en) | 1996-01-24 |
| EP0684241B1 (de) | 1997-08-27 |
| JP3048511B2 (ja) | 2000-06-05 |
| CN1053904C (zh) | 2000-06-28 |
| NO952075L (no) | 1995-11-28 |
| JPH07330764A (ja) | 1995-12-19 |
| NO308359B1 (no) | 2000-09-04 |
| GR3024799T3 (en) | 1998-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |