ATE136224T1 - Reduktion der nichtzielspezifischen retention von immunokonjugaten und ihren metaboliten - Google Patents
Reduktion der nichtzielspezifischen retention von immunokonjugaten und ihren metabolitenInfo
- Publication number
- ATE136224T1 ATE136224T1 AT90915344T AT90915344T ATE136224T1 AT E136224 T1 ATE136224 T1 AT E136224T1 AT 90915344 T AT90915344 T AT 90915344T AT 90915344 T AT90915344 T AT 90915344T AT E136224 T1 ATE136224 T1 AT E136224T1
- Authority
- AT
- Austria
- Prior art keywords
- immunoconjugates
- metabolites
- target
- reduction
- retention
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41505589A | 1989-09-29 | 1989-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE136224T1 true ATE136224T1 (de) | 1996-04-15 |
Family
ID=23644186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90915344T ATE136224T1 (de) | 1989-09-29 | 1990-09-24 | Reduktion der nichtzielspezifischen retention von immunokonjugaten und ihren metaboliten |
Country Status (7)
Country | Link |
---|---|
US (2) | US5380513A (de) |
EP (1) | EP0494247B1 (de) |
JP (1) | JPH05500953A (de) |
AT (1) | ATE136224T1 (de) |
CA (1) | CA2066031C (de) |
DE (1) | DE69026387T2 (de) |
WO (1) | WO1991004755A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991004755A1 (en) * | 1989-09-29 | 1991-04-18 | Neorx Corporation | Methods for reducing non-target retention of immunoconjugates and metabolites thereof |
GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US5843894A (en) * | 1995-03-21 | 1998-12-01 | Center For Molecular Medicine And Immunology | Methods for reduced renal uptake of antibody fragments |
WO2001005383A2 (en) * | 1999-07-16 | 2001-01-25 | Mallinckrodt, Inc. | Inhibition of renal uptake of radiomolecules with a combination of lysine and arginine |
ITMI20010347A1 (it) * | 2001-02-21 | 2002-08-21 | Grisotech S A | Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale |
EP1419786A1 (de) * | 2002-11-13 | 2004-05-19 | Bracco Imaging S.p.A. | Verfahren zur quantitativen und selektiven Funktionalisierung von Immunoglobulin-Fab-Fragmenten, deren Konjugate und deren Zusammensetzungen |
US20070184501A1 (en) * | 2006-02-07 | 2007-08-09 | Beckman Coulter, Inc. | Blocker reagent for reduction of heterophile interferences |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4916213A (en) * | 1983-02-22 | 1990-04-10 | Xoma Corporation | Ribosomal inhibiting protein-immunoglobulin conjugates with specificity for tumor cell surface antigens, and mixtures thereof |
US4624846A (en) * | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
EP0268707A3 (de) * | 1985-11-05 | 1989-03-08 | The General Hospital Corporation | Negativ geladene spezifische Affinitätsreagenzien |
US4731244A (en) * | 1985-11-13 | 1988-03-15 | Ortho Pharmaceutical Corporation | Monoclonal antibody therapy |
AU616161B2 (en) * | 1986-10-09 | 1991-10-24 | Neorx Corporation | Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof |
US5034223A (en) * | 1986-10-09 | 1991-07-23 | Neorx Corporation | Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof |
US4946675A (en) * | 1987-05-27 | 1990-08-07 | Xoma Corporation | Hepatic blocking agents |
US4859449A (en) * | 1987-09-14 | 1989-08-22 | Center For Molecular Medicine And Immunology | Modified antibodies for enhanced hepatocyte clearance |
US5322678A (en) * | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
US5171563A (en) * | 1988-09-30 | 1992-12-15 | Neorx Corporation | Cleavable linkers for the reduction of non-target organ retention of immunoconjugates |
WO1991004755A1 (en) * | 1989-09-29 | 1991-04-18 | Neorx Corporation | Methods for reducing non-target retention of immunoconjugates and metabolites thereof |
-
1990
- 1990-09-24 WO PCT/US1990/005416 patent/WO1991004755A1/en active IP Right Grant
- 1990-09-24 EP EP90915344A patent/EP0494247B1/de not_active Expired - Lifetime
- 1990-09-24 CA CA002066031A patent/CA2066031C/en not_active Expired - Fee Related
- 1990-09-24 DE DE69026387T patent/DE69026387T2/de not_active Expired - Fee Related
- 1990-09-24 JP JP2514345A patent/JPH05500953A/ja active Pending
- 1990-09-24 AT AT90915344T patent/ATE136224T1/de not_active IP Right Cessation
-
1992
- 1992-08-21 US US07/933,608 patent/US5380513A/en not_active Expired - Lifetime
-
1994
- 1994-11-08 US US08/337,477 patent/US5648059A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69026387D1 (de) | 1996-05-09 |
DE69026387T2 (de) | 1996-11-28 |
US5380513A (en) | 1995-01-10 |
EP0494247A1 (de) | 1992-07-15 |
CA2066031C (en) | 2001-02-27 |
US5648059A (en) | 1997-07-15 |
EP0494247B1 (de) | 1996-04-03 |
WO1991004755A1 (en) | 1991-04-18 |
CA2066031A1 (en) | 1991-03-30 |
JPH05500953A (ja) | 1993-02-25 |
EP0494247A4 (de) | 1994-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |