ATE134643T1 - Verfahren zur herstellung von zidovudine - Google Patents
Verfahren zur herstellung von zidovudineInfo
- Publication number
- ATE134643T1 ATE134643T1 AT92914161T AT92914161T ATE134643T1 AT E134643 T1 ATE134643 T1 AT E134643T1 AT 92914161 T AT92914161 T AT 92914161T AT 92914161 T AT92914161 T AT 92914161T AT E134643 T1 ATE134643 T1 AT E134643T1
- Authority
- AT
- Austria
- Prior art keywords
- zidovudine
- producing
- azt
- complex
- deoxythymidine
- Prior art date
Links
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960002555 zidovudine Drugs 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71783191A | 1991-06-21 | 1991-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE134643T1 true ATE134643T1 (de) | 1996-03-15 |
Family
ID=24883679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92914161T ATE134643T1 (de) | 1991-06-21 | 1992-06-22 | Verfahren zur herstellung von zidovudine |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5387677A (de) |
| EP (1) | EP0550714B1 (de) |
| AT (1) | ATE134643T1 (de) |
| AU (1) | AU2181592A (de) |
| CA (1) | CA2090026C (de) |
| DE (2) | DE550714T1 (de) |
| ES (1) | ES2085023T3 (de) |
| HU (1) | HUT63852A (de) |
| WO (1) | WO1993000351A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2111970C1 (ru) * | 1996-06-25 | 1998-05-27 | Иван Игоревич Федоров | 3'-оксимино-2',3'-дидезоксинуклеозиды |
| RU2392969C1 (ru) * | 2008-11-18 | 2010-06-27 | Общество с ограниченной ответственностью "Базис" | Способ получения биоцидного средства |
| CN102731600B (zh) * | 2012-03-13 | 2013-06-19 | 绿洲生物技术（南通）有限公司 | 齐多夫定及其中间体的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| US4874751A (en) * | 1985-03-16 | 1989-10-17 | Burroughs Wellcome Co. | Antibacterial treatment |
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
| US4847244A (en) * | 1985-09-17 | 1989-07-11 | Burroughs Wellcome Co. | Treatment of human viral infections |
| DE3650741T2 (de) * | 1985-09-17 | 2000-10-12 | The Wellcome Foundation Ltd., Greenford | Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten. |
| US4818750A (en) * | 1985-09-17 | 1989-04-04 | Burroughs Wellcome Co. | Treatment of human viral infections |
| US4857511A (en) * | 1985-09-17 | 1989-08-15 | Burroughs Wellcome Co. | Treatment of human viral infections |
| GB8707421D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
| US4837311A (en) * | 1987-06-22 | 1989-06-06 | Hoffman-La Roche Inc. | Anti-retroviral compounds |
| US4904770A (en) * | 1988-03-24 | 1990-02-27 | Bristol-Myers Company | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
| US4921950A (en) * | 1988-06-09 | 1990-05-01 | Burroughs Wellcome Co. | Preparation of 3'azido-3-'-deoxythymidine |
| US4916218A (en) * | 1988-06-09 | 1990-04-10 | Almond Merrick R | 1-(β-D-xylofuranosyl)thymine derivatives |
-
1992
- 1992-06-22 DE DE0550714T patent/DE550714T1/de active Pending
- 1992-06-22 AT AT92914161T patent/ATE134643T1/de not_active IP Right Cessation
- 1992-06-22 DE DE69208636T patent/DE69208636T2/de not_active Expired - Fee Related
- 1992-06-22 WO PCT/CA1992/000269 patent/WO1993000351A1/en not_active Ceased
- 1992-06-22 ES ES92914161T patent/ES2085023T3/es not_active Expired - Lifetime
- 1992-06-22 CA CA002090026A patent/CA2090026C/en not_active Expired - Fee Related
- 1992-06-22 EP EP92914161A patent/EP0550714B1/de not_active Expired - Lifetime
- 1992-06-22 HU HU9300462A patent/HUT63852A/hu unknown
- 1992-06-22 AU AU21815/92A patent/AU2181592A/en not_active Abandoned
- 1992-07-16 US US07/914,104 patent/US5387677A/en not_active Expired - Fee Related
-
1994
- 1994-10-21 US US08/326,854 patent/US5519129A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0550714B1 (de) | 1996-02-28 |
| DE69208636T2 (de) | 1996-07-11 |
| WO1993000351A1 (en) | 1993-01-07 |
| DE550714T1 (de) | 1995-06-14 |
| CA2090026A1 (en) | 1992-12-22 |
| HU9300462D0 (en) | 1993-05-28 |
| HUT63852A (en) | 1993-10-28 |
| AU2181592A (en) | 1993-01-25 |
| ES2085023T3 (es) | 1996-05-16 |
| CA2090026C (en) | 1995-09-19 |
| US5519129A (en) | 1996-05-21 |
| US5387677A (en) | 1995-02-07 |
| EP0550714A1 (de) | 1993-07-14 |
| DE69208636D1 (de) | 1996-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |