DE69011859D1 - Verwendung von sigma-rezeptor-liganden zur herstellung eines anxiolytikums. - Google Patents
Verwendung von sigma-rezeptor-liganden zur herstellung eines anxiolytikums.Info
- Publication number
- DE69011859D1 DE69011859D1 DE69011859T DE69011859T DE69011859D1 DE 69011859 D1 DE69011859 D1 DE 69011859D1 DE 69011859 T DE69011859 T DE 69011859T DE 69011859 T DE69011859 T DE 69011859T DE 69011859 D1 DE69011859 D1 DE 69011859D1
- Authority
- DE
- Germany
- Prior art keywords
- sigma receptor
- receptor ligands
- anxiolytic
- producing
- producing anxiolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34649489A | 1989-05-02 | 1989-05-02 | |
PCT/US1990/002398 WO1990014067A2 (en) | 1989-05-02 | 1990-05-02 | Methods for treating anxiety with sigma receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69011859D1 true DE69011859D1 (de) | 1994-09-29 |
DE69011859T2 DE69011859T2 (de) | 1994-12-15 |
Family
ID=23359655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69011859T Expired - Fee Related DE69011859T2 (de) | 1989-05-02 | 1990-05-02 | Verwendung von sigma-rezeptor-liganden zur herstellung eines anxiolytikums. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0473671B1 (de) |
JP (1) | JPH05500798A (de) |
AT (1) | ATE110265T1 (de) |
AU (1) | AU642881B2 (de) |
CA (1) | CA2054211A1 (de) |
DE (1) | DE69011859T2 (de) |
DK (1) | DK0473671T3 (de) |
ES (1) | ES2057568T3 (de) |
WO (1) | WO1990014067A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5312840A (en) * | 1986-07-10 | 1994-05-17 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education | Substituted guanidines having high binding to the sigma receptor and the use thereof |
US5478863A (en) * | 1986-07-10 | 1995-12-26 | State Of Oregon, Oregon Health Sciences University Of Oregon | Substituted guanidines having high binding to the sigma receptor and the use thereof |
EP0517852B1 (de) | 1990-03-02 | 2002-07-10 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of | Tri- und tetra-substituierte guanidine und deren verwendung als antagonisten von exzitatorischen aminosäuren |
US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
JPH05508836A (ja) * | 1990-05-25 | 1993-12-09 | オレゴン州 | シグマ受容体に対して高い結合性を有する置換グアニジンおよびその使用 |
US5847006A (en) * | 1991-02-08 | 1998-12-08 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
US5741661A (en) * | 1991-02-08 | 1998-04-21 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
AU670232B2 (en) * | 1991-02-08 | 1996-07-11 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
CA2163361C (en) * | 1993-05-27 | 2008-06-17 | Graham J. Durant | Therapeutic substituted guanidines |
CA2177084A1 (en) * | 1993-11-22 | 1995-06-01 | Sharad Magar | Therapeutic guanidines |
CA2177081A1 (en) * | 1993-11-23 | 1995-06-01 | Graham J. Durant | Therapeutic substituted guanidines |
US6143791A (en) * | 1994-02-03 | 2000-11-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
ZA95878B (en) | 1994-02-03 | 1996-01-16 | Cambridge Neuroscience Inc | Therapeutic guanidines |
US6787569B1 (en) | 1994-02-03 | 2004-09-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
US7351743B1 (en) | 1994-02-03 | 2008-04-01 | Wyeth | Therapeutic guanidines |
AU1882395A (en) * | 1994-02-23 | 1995-09-11 | Cambridge Neuroscience, Inc. | Blockers of ion channels and methods of use thereof |
US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
EP1749824A1 (de) | 2005-08-03 | 2007-02-07 | Neuro3D | Benzodiazepinederivate, Herstellung und Verwendung als Arzneimittel |
EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
EP2377530A3 (de) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation von Neurogenese durch PDE-Hemmung |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2382975A3 (de) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
JP6397407B2 (ja) * | 2012-07-19 | 2018-09-26 | ドレクセル ユニバーシティ | 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド |
WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4709094A (en) * | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
-
1990
- 1990-05-02 AT AT90908385T patent/ATE110265T1/de not_active IP Right Cessation
- 1990-05-02 AU AU57287/90A patent/AU642881B2/en not_active Ceased
- 1990-05-02 JP JP2508151A patent/JPH05500798A/ja active Pending
- 1990-05-02 ES ES90908385T patent/ES2057568T3/es not_active Expired - Lifetime
- 1990-05-02 CA CA002054211A patent/CA2054211A1/en not_active Abandoned
- 1990-05-02 EP EP90908385A patent/EP0473671B1/de not_active Expired - Lifetime
- 1990-05-02 DK DK90908385.9T patent/DK0473671T3/da active
- 1990-05-02 DE DE69011859T patent/DE69011859T2/de not_active Expired - Fee Related
- 1990-05-02 WO PCT/US1990/002398 patent/WO1990014067A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0473671B1 (de) | 1994-08-24 |
JPH05500798A (ja) | 1993-02-18 |
WO1990014067A3 (en) | 1991-04-04 |
DK0473671T3 (da) | 1994-09-19 |
EP0473671A1 (de) | 1992-03-11 |
AU642881B2 (en) | 1993-11-04 |
ES2057568T3 (es) | 1994-10-16 |
ATE110265T1 (de) | 1994-09-15 |
WO1990014067A2 (en) | 1990-11-29 |
EP0473671A4 (en) | 1992-04-01 |
DE69011859T2 (de) | 1994-12-15 |
AU5728790A (en) | 1990-12-18 |
CA2054211A1 (en) | 1990-11-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |