ATE131159T1 - 1-alkyl-3-(acylamino)-epsilon-caprolactame zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen. - Google Patents

1-alkyl-3-(acylamino)-epsilon-caprolactame zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen.

Info

Publication number
ATE131159T1
ATE131159T1 AT91830276T AT91830276T ATE131159T1 AT E131159 T1 ATE131159 T1 AT E131159T1 AT 91830276 T AT91830276 T AT 91830276T AT 91830276 T AT91830276 T AT 91830276T AT E131159 T1 ATE131159 T1 AT E131159T1
Authority
AT
Austria
Prior art keywords
acylamino
alkyl
memory
epsilone
caprolactame
Prior art date
Application number
AT91830276T
Other languages
English (en)
Inventor
Fabio Giannessi
Orlando Ghirardi
Domenico Misiti
Maria Ornella Tinti
Roberto Cozzolino
Carlo Scolastico
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE131159T1 publication Critical patent/ATE131159T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT91830276T 1990-06-21 1991-06-20 1-alkyl-3-(acylamino)-epsilon-caprolactame zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen. ATE131159T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04808790A IT1247698B (it) 1990-06-21 1990-06-21 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (1)

Publication Number Publication Date
ATE131159T1 true ATE131159T1 (de) 1995-12-15

Family

ID=11264450

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91830276T ATE131159T1 (de) 1990-06-21 1991-06-20 1-alkyl-3-(acylamino)-epsilon-caprolactame zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen.

Country Status (9)

Country Link
US (1) US5155102A (de)
EP (1) EP0462949B1 (de)
JP (1) JPH04230266A (de)
AT (1) ATE131159T1 (de)
DE (1) DE69115135T2 (de)
DK (1) DK0462949T3 (de)
ES (1) ES2081463T3 (de)
GR (1) GR3019076T3 (de)
IT (1) IT1247698B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1156803A4 (de) 1999-02-09 2004-03-17 Bristol Myers Squibb Co LACTAM INHIBITOREN DES FXa UND METHODE
US6344450B1 (en) 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
JP2002536437A (ja) * 1999-02-09 2002-10-29 ブリストル−マイヤーズ スクイブ カンパニー ＦＸａのラクタム抑制剤および方法
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
SI1691814T1 (sl) * 2003-12-01 2012-11-30 Cambridge Entpr Ltd Protivnetna zdravila
EP1732885A1 (de) * 2004-02-23 2006-12-20 Trustees Of Tufts College Lactame als konformationsgehinderte peptidomimetische inhibitoren
GB2418425B (en) * 2004-08-11 2008-09-03 Univ Cambridge Tech Anti-inflammatory agents
GB201009603D0 (en) 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231921B (it) * 1989-06-12 1992-01-15 Sigma Tau Ind Farmaceuti 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Also Published As

Publication number Publication date
DK0462949T3 (da) 1996-02-05
EP0462949A1 (de) 1991-12-27
ES2081463T3 (es) 1996-03-16
GR3019076T3 (en) 1996-05-31
IT9048087A0 (it) 1990-06-21
JPH04230266A (ja) 1992-08-19
US5155102A (en) 1992-10-13
DE69115135D1 (de) 1996-01-18
DE69115135T2 (de) 1996-05-09
IT9048087A1 (it) 1991-12-21
EP0462949B1 (de) 1995-12-06
IT1247698B (it) 1994-12-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee