ATE119039T1 - Immunosuppressant und verfahren zu seiner herstellung. - Google Patents

Immunosuppressant und verfahren zu seiner herstellung.

Info

Publication number
ATE119039T1
ATE119039T1 AT90917694T AT90917694T ATE119039T1 AT E119039 T1 ATE119039 T1 AT E119039T1 AT 90917694 T AT90917694 T AT 90917694T AT 90917694 T AT90917694 T AT 90917694T AT E119039 T1 ATE119039 T1 AT E119039T1
Authority
AT
Austria
Prior art keywords
alkyl
immunosuppressant
production
day
antagonist
Prior art date
Application number
AT90917694T
Other languages
English (en)
Inventor
Hiroshi Nagase
Koji Kawai
Shu Matsumoto
Takashi Endoh
Yoshiaki Katsura
Kohei Arakawa
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE119039T1 publication Critical patent/ATE119039T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
AT90917694T 1989-11-28 1990-11-28 Immunosuppressant und verfahren zu seiner herstellung. ATE119039T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30849189 1989-11-28
JP32216089 1989-12-11
JP32694189 1989-12-15

Publications (1)

Publication Number Publication Date
ATE119039T1 true ATE119039T1 (de) 1995-03-15

Family

ID=27338974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90917694T ATE119039T1 (de) 1989-11-28 1990-11-28 Immunosuppressant und verfahren zu seiner herstellung.

Country Status (14)

Country Link
US (1) US5332818A (de)
EP (1) EP0456833B1 (de)
JP (1) JP2906654B2 (de)
KR (1) KR940008032B1 (de)
AT (1) ATE119039T1 (de)
AU (1) AU639053B2 (de)
CA (1) CA2045481C (de)
DE (1) DE69017434T2 (de)
DK (1) DK0456833T3 (de)
ES (1) ES2069100T3 (de)
FI (1) FI913583A0 (de)
GR (1) GR3015266T3 (de)
NO (1) NO912940L (de)
WO (1) WO1991007966A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852030A (en) * 1992-09-29 1998-12-22 Toray Industries, Inc. Indole derivatives, process for producing the same and medicinal uses of the same
CN1043766C (zh) * 1992-09-29 1999-06-23 东丽株式会社 吲哚衍生物及其制法和它们在制备药物中的应用
CA2130457A1 (en) * 1992-12-22 1994-07-07 Hiroshi Nagase Antitussive
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9304236D0 (sv) * 1993-12-22 1993-12-22 Astra Ab New use
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
US6365594B1 (en) * 1996-01-10 2002-04-02 Smithkline Beecham S.P.A. Heterocycle-condensed morphinoid derivatives (II)
NZ331769A (en) * 1997-01-16 2000-05-26 Toray Industries Indolomorphinan derivative and agent for curing and preventing cerebral disorder
AU6520198A (en) 1997-03-31 1998-10-22 Toray Industries, Inc. Quinolinomorphinane derivatives and medicinal use thereof
US6359111B1 (en) 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
JP2004529161A (ja) 2001-05-04 2004-09-24 トゥラリック インコーポレイテッド 縮合複素環式化合物
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
EP1517689A2 (de) * 2002-01-25 2005-03-30 Regents Of The University Of Minnesota Selektive analgetika
WO2004007503A1 (ja) * 2002-07-11 2004-01-22 Toray Industries, Inc. 悪心・嘔吐の治療または予防剤
AU2003285160B2 (en) 2002-11-06 2009-06-04 Amgen Inc. Fused heterocyclic compounds
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CN1298718C (zh) * 2005-03-18 2007-02-07 中国科学院上海有机化学研究所 C环连接有吡嗪环的青藤碱衍生物、合成方法及其用途
US20070185145A1 (en) * 2006-02-03 2007-08-09 Royds Robert B Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443605A (en) * 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases

Also Published As

Publication number Publication date
CA2045481C (en) 1995-11-14
DE69017434D1 (de) 1995-04-06
AU6876891A (en) 1991-06-26
ES2069100T3 (es) 1995-05-01
GR3015266T3 (en) 1995-06-30
FI913583A0 (fi) 1991-07-26
DK0456833T3 (da) 1995-05-01
DE69017434T2 (de) 1995-06-29
NO912940D0 (no) 1991-07-29
EP0456833A1 (de) 1991-11-21
AU639053B2 (en) 1993-07-15
JP2906654B2 (ja) 1999-06-21
EP0456833A4 (en) 1992-03-18
KR940008032B1 (ko) 1994-09-01
KR920700643A (ko) 1992-08-10
WO1991007966A1 (fr) 1991-06-13
US5332818A (en) 1994-07-26
CA2045481A1 (en) 1991-05-29
EP0456833B1 (de) 1995-03-01
NO912940L (no) 1991-07-29
JPH03223288A (ja) 1991-10-02

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Legal Events

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REN Ceased due to non-payment of the annual fee