ATE1150T1 - Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen. - Google Patents
Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen.Info
- Publication number
- ATE1150T1 ATE1150T1 AT80100447T AT80100447T ATE1150T1 AT E1150 T1 ATE1150 T1 AT E1150T1 AT 80100447 T AT80100447 T AT 80100447T AT 80100447 T AT80100447 T AT 80100447T AT E1150 T1 ATE1150 T1 AT E1150T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- compositions containing
- anthracyclinglycosides
- production
- therapeutic compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229960000975 daunorubicin Drugs 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7903700 | 1979-02-02 | ||
| EP80100447A EP0014425B1 (de) | 1979-02-02 | 1980-01-29 | Anthracyclinglycosiden, Verfahren zu deren Herstellung und sie enthaltende therapeutische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE1150T1 true ATE1150T1 (de) | 1982-06-15 |
Family
ID=10502917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80100447T ATE1150T1 (de) | 1979-02-02 | 1980-01-29 | Anthracyclinglycosiden, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4254110A (de) |
| EP (1) | EP0014425B1 (de) |
| JP (1) | JPS55133370A (de) |
| AT (1) | ATE1150T1 (de) |
| DE (1) | DE3060481D1 (de) |
| DK (1) | DK45080A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314999A (en) * | 1978-07-31 | 1982-02-09 | Proter S.P.A. | N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity |
| DE51279T1 (de) * | 1980-11-01 | 1983-05-26 | Farmitalia Carlo Erba S.p.A., 20159 Milano | Anthracyclin-glycoside, zwischenprodukte, verfahren zu beider herstellung und arzneimittel. |
| GB2196626B (en) * | 1986-10-15 | 1990-09-19 | Erba Farmitalia | Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor |
| FR2660561B1 (fr) * | 1990-04-06 | 1994-05-13 | Technomed International | Sonde rectale. |
| US7388083B2 (en) * | 2005-03-07 | 2008-06-17 | Solux Corporation | Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics |
| US8802830B2 (en) | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8357785B2 (en) | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130756C (de) * | 1964-03-02 | |||
| GB1542920A (en) * | 1976-12-22 | 1979-03-28 | Farmaceutici Italia | Antitumour glycosides |
| GB1550879A (en) * | 1976-12-22 | 1979-08-22 | Farmaceutici Italia | Antitumour glycosides |
| US4181795A (en) * | 1978-05-22 | 1980-01-01 | Purdue Research Foundation | Daunosamine synthesis |
-
1980
- 1980-01-28 US US06/115,725 patent/US4254110A/en not_active Expired - Lifetime
- 1980-01-29 AT AT80100447T patent/ATE1150T1/de not_active IP Right Cessation
- 1980-01-29 DE DE8080100447T patent/DE3060481D1/de not_active Expired
- 1980-01-29 EP EP80100447A patent/EP0014425B1/de not_active Expired
- 1980-02-01 JP JP1015980A patent/JPS55133370A/ja active Granted
- 1980-02-01 DK DK45080A patent/DK45080A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0014425B1 (de) | 1982-06-02 |
| EP0014425A1 (de) | 1980-08-20 |
| DE3060481D1 (en) | 1982-07-22 |
| JPS6321671B2 (de) | 1988-05-09 |
| JPS55133370A (en) | 1980-10-17 |
| DK45080A (da) | 1980-08-03 |
| US4254110A (en) | 1981-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |