ATE110571T1 - Stabile interferon-beta-zusammensetzung. - Google Patents

Stabile interferon-beta-zusammensetzung.

Info

Publication number
ATE110571T1
ATE110571T1 AT89905176T AT89905176T ATE110571T1 AT E110571 T1 ATE110571 T1 AT E110571T1 AT 89905176 T AT89905176 T AT 89905176T AT 89905176 T AT89905176 T AT 89905176T AT E110571 T1 ATE110571 T1 AT E110571T1
Authority
AT
Austria
Prior art keywords
interferon beta
composition
stable interferon
beta composition
stable
Prior art date
Application number
AT89905176T
Other languages
English (en)
Inventor
Michio Hara
Makoto Taniguchi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE110571T1 publication Critical patent/ATE110571T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT89905176T 1988-05-06 1989-05-02 Stabile interferon-beta-zusammensetzung. ATE110571T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11092188 1988-05-06

Publications (1)

Publication Number Publication Date
ATE110571T1 true ATE110571T1 (de) 1994-09-15

Family

ID=14548004

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89905176T ATE110571T1 (de) 1988-05-06 1989-05-02 Stabile interferon-beta-zusammensetzung.

Country Status (4)

Country Link
EP (1) EP0374257B1 (de)
AT (1) ATE110571T1 (de)
DE (1) DE68917883T2 (de)
WO (1) WO1989010756A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2304808C (en) 1997-09-23 2011-03-22 Michael Tschope Liquid interferon-.beta. formulations
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
EP2654742A4 (de) 2010-12-26 2014-10-15 Univ Carmel Haifa Economic Cor Verfahren zur verbesserung der kognitiven funktion
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
WO2013157002A1 (en) 2012-04-19 2013-10-24 Prolor Biotech Inc. Long-acting oxyntomodulin variants and methods of producing same
SG11201408054RA (en) 2012-06-04 2015-01-29 Opko Biolog Ltd Pegylated oxm variants
EP2922867B1 (de) 2012-11-20 2021-07-21 OPKO Biologics Ltd. Verfahren zur erhöhung des hydrodynamischen volumens von polypeptiden durch bindung an gonadotrophin-carboxy-terminale peptide
TW201536312A (zh) 2013-10-21 2015-10-01 Opko Biolog Ltd 長效型多肽及其生產和給藥的方法
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
KR102527180B1 (ko) 2014-12-10 2023-04-27 옵코 바이오로직스 리미티드 장기간 작용성 ctp-변형된 성장 호르몬 폴리펩타이드의 제조 방법
AU2016273045B2 (en) 2015-05-29 2020-11-26 Opko Biologics Ltd. Pegylated oxyntomodulin variants
PL3310347T3 (pl) 2015-06-19 2021-12-27 Opko Biologics Ltd. Długo działające czynniki krzepnięcia i sposoby wytwarzania
EP3468610A1 (de) 2016-06-09 2019-04-17 OPKO Biologics Ltd. Langwirkende oxyntomodulinformulierung und verfahren zur herstellung und verabreichung davon
CA3030533A1 (en) 2016-07-11 2018-01-18 Oren HERSHKOVITZ Long-acting coagulation factor vii and methods of producing same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483849A (en) * 1983-01-07 1984-11-20 Carter William A Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product
JPS59196823A (ja) * 1983-04-20 1984-11-08 Sunstar Inc 皮膚および粘膜の真菌症治療用外用剤
JPS6069037A (ja) * 1983-09-26 1985-04-19 Sunstar Inc エリテマト−デス治療用外用剤
US4680175A (en) * 1984-02-07 1987-07-14 Interferon Sciences, Inc. Interferon administration vehicles
US4710376A (en) * 1985-02-01 1987-12-01 Interferon Sciences, Inc. Topical therapeutic composition containing oxidation inhibitor system
JPH0667851B2 (ja) * 1985-12-27 1994-08-31 東レ株式会社 インタ−フエロンβ組成物
DE3603444A1 (de) * 1986-02-05 1987-08-06 Thomae Gmbh Dr K Pharmazeutische zubereitungsformen zur stabilisierung von interferon alpha
JP3198392B2 (ja) * 1992-08-13 2001-08-13 株式会社トーキン 巻線チップインダクタ及びその製造方法

Also Published As

Publication number Publication date
DE68917883D1 (de) 1994-10-06
WO1989010756A1 (en) 1989-11-16
EP0374257A1 (de) 1990-06-27
EP0374257B1 (de) 1994-08-31
DE68917883T2 (de) 1995-02-23
EP0374257A4 (en) 1991-06-05

Similar Documents

Publication Publication Date Title
ATE110571T1 (de) Stabile interferon-beta-zusammensetzung.
ZA877132B (en) Drug compositions stabilized against oxidation
ES2040231T3 (es) Composiciones medicamentosas estables.
SE8502432D0 (sv) Improvement of flow properties of injection moldable aromatic polyesters
FR2636238B1 (fr) Nouvelles compositions antisudorales
SE9203853D0 (sv) Moisture curable compositions and method of curing moisture curable compositions
ATE163667T1 (de) Stabilisierte polyacetalzubereitungen
GR1001218B (el) Μεθοδος παρασκευης αλατων κεφαλοσπορινης και ενεσιμων συνθεσεων
NO895186D0 (no) Regulering av mikrobiell vekst med nisin/lysosym formuleringer.
IL97749A0 (en) Method of stabilizing isothiazolones by the use of phenoxy-alkanols and stabilized compositions of isothiazolones comprising phenoxyalkanols
IT8419046A0 (it) Composizioni vulcanizzabili di fluoroelastomeri aventi migliorate caratteristiche di autolubrificazione ed elevata velocita' di vulcanizzazione.
AR240802A2 (es) Derivados de 3-fenil-4-cianopirrol, procedimiento para su preparacion y composiciones microbicidas que los contienen
FR2569414B1 (fr) Compositions de polyorganosiloxane vulcanisables a temperature ambiante a stabilite de conservation amelioree
FI863078A0 (fi) Kontinuerligt frigoerande peptidkompositioner.
NO178213C (no) Anvendelse av en antimikrobiologisk sammensetning
IT1243441B (it) Composizioni di polifenilenossido o di miscele di polifenilenossido ststabilizzate con beta-dichetoni
BR9005006A (pt) Composicoes de tipo azeotropico estabilizadas de 1,1-dicloro-2,2,2-trifluoroetano e 1,1-dicloro-1-fluoroetano
BR8700698A (pt) Composicao fungicida e composicao de protecao de madeira,a base de sal de morfolina substituida com acido fluoborico
FI863079A (fi) Kontinuerligt frigoerande fenyletanolaminderivatkompositioner.
ES8708226A1 (es) Procedimiento para la produccion de derivados de 1,4-dihi- dropiridina
ATE21381T1 (de) Stabilisierte zusammensetzungen von 1,1,1trichlor|than.
FI854788A (fi) Nya 13 -alkyl-17 - (3-acyloxipropyl)-gonaner.
ITPN910024V0 (it) Compressore con supporto perfezionato di protettore termico
DE68919562D1 (de) Polyester-Zusammensetzungen.
JPS5283672A (en) Novel 2-amino-1,4-dihydropyridine derivatives

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties