ATE105544T1 - Neue enzymsubstrate auf der basis von fettsaeureanalogen. - Google Patents

Neue enzymsubstrate auf der basis von fettsaeureanalogen.

Info

Publication number
ATE105544T1
ATE105544T1 AT9191870022T AT91870022T ATE105544T1 AT E105544 T1 ATE105544 T1 AT E105544T1 AT 9191870022 T AT9191870022 T AT 9191870022T AT 91870022 T AT91870022 T AT 91870022T AT E105544 T1 ATE105544 T1 AT E105544T1
Authority
AT
Austria
Prior art keywords
fatty acid
enzyme substrates
acid analogues
substrates based
new enzyme
Prior art date
Application number
AT9191870022T
Other languages
English (en)
Inventor
Robert Otto Heuckeroth
Steven Paul Adams
Jeffrey Ivan Gordon
George William Gokel
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE105544T1 publication Critical patent/ATE105544T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT9191870022T 1990-02-09 1991-02-08 Neue enzymsubstrate auf der basis von fettsaeureanalogen. ATE105544T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/478,298 US5082967A (en) 1988-06-16 1990-02-09 Novel fatty acid analog enzyme substrates

Publications (1)

Publication Number Publication Date
ATE105544T1 true ATE105544T1 (de) 1994-05-15

Family

ID=23899339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9191870022T ATE105544T1 (de) 1990-02-09 1991-02-08 Neue enzymsubstrate auf der basis von fettsaeureanalogen.

Country Status (8)

Country Link
US (1) US5082967A (de)
EP (1) EP0441765B1 (de)
JP (1) JPH05271181A (de)
AT (1) ATE105544T1 (de)
CA (1) CA2036027A1 (de)
DE (1) DE69101934T2 (de)
DK (1) DK0441765T3 (de)
ES (1) ES2054480T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036965A1 (en) * 1990-02-26 1991-08-27 Robert J. Duronio Method for protein n-myristoylation
ES2088480T3 (es) * 1990-10-12 1996-08-16 Univ Washington Sustratos de enzimas analogos de acidos grasos sustituidos con azido.
WO1993012142A1 (en) * 1991-12-10 1993-06-24 Tanox Biosystems, Inc. Cytokines with an unpaired cysteine residue and conjugates thereof
US5236955A (en) * 1992-04-10 1993-08-17 Washington University Anti-fungal agent
US6602861B1 (en) * 1992-04-16 2003-08-05 Research Corporation Technologies, Inc. Acylated phospholipid drugs
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5599947A (en) * 1993-01-14 1997-02-04 G. D. Searle & Co. Fatty acid analogs and prodrugs
US6410775B1 (en) * 1995-06-07 2002-06-25 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
ES2217882T3 (es) * 1998-12-18 2004-11-01 Basilea Pharmaceutica Ag 4-(aminoalcoxy)benzofuranos como inhibidores de n-miristoiltransferasa.
US11021430B2 (en) 2016-04-05 2021-06-01 Moresco Corporation Oxa acid compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654326A (en) * 1970-07-22 1972-04-04 Hoffmann La Roche 5 9-dioxodecanoic acids and methods for their preparation
DE3135946A1 (de) * 1981-09-10 1983-03-24 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von alkoxyessigsaeuren
DE3230677A1 (de) * 1982-08-18 1984-02-23 Chemische Werke Hüls AG, 4370 Marl Verfahren zur herstellung von carboxymethylierten alkoholen, etheralkoholen, thioalkoholen oder alkylphenolen
US4778877A (en) * 1986-08-07 1988-10-18 Washington University Novel inhibitor peptides II
US4740588A (en) * 1986-08-07 1988-04-26 Washington University Novel substrate peptides
US4778878A (en) * 1986-08-07 1988-10-18 Washington University Novel inhibitor peptides I
TR23339A (tr) * 1987-06-15 1989-12-14 Henkel Kgaa Alkoksillendirme icin katalizoer,olarak eter karbonik asitlerinin toprak alkalisi tozlarinin kullanilmasi
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
DE68901781T2 (de) * 1988-02-03 1993-01-07 Univ Washington Enzymsubstrate auf der basis neuer fettsaeureanaloge.

Also Published As

Publication number Publication date
ES2054480T3 (es) 1994-08-01
DK0441765T3 (da) 1994-06-13
DE69101934D1 (de) 1994-06-16
JPH05271181A (ja) 1993-10-19
EP0441765B1 (de) 1994-05-11
CA2036027A1 (en) 1991-08-10
EP0441765A1 (de) 1991-08-14
DE69101934T2 (de) 1994-12-08
US5082967A (en) 1992-01-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee