DE68901781T2 - Enzymsubstrate auf der basis neuer fettsaeureanaloge. - Google Patents

Enzymsubstrate auf der basis neuer fettsaeureanaloge.

Info

Publication number
DE68901781T2
DE68901781T2 DE8989870019T DE68901781T DE68901781T2 DE 68901781 T2 DE68901781 T2 DE 68901781T2 DE 8989870019 T DE8989870019 T DE 8989870019T DE 68901781 T DE68901781 T DE 68901781T DE 68901781 T2 DE68901781 T2 DE 68901781T2
Authority
DE
Germany
Prior art keywords
fatty acid
acid analogs
enzyme substrates
substrates based
new fatty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989870019T
Other languages
English (en)
Other versions
DE68901781D1 (de
Inventor
Steven Paul Adams
Robert Otto Heuckeroth
Jeffrey Ivan Gordon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESEARCH CORPORATION TECHNOLOGIES, INC. (N.D.GES.D
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of DE68901781D1 publication Critical patent/DE68901781D1/de
Application granted granted Critical
Publication of DE68901781T2 publication Critical patent/DE68901781T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8989870019T 1988-02-03 1989-02-01 Enzymsubstrate auf der basis neuer fettsaeureanaloge. Expired - Fee Related DE68901781T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15177488A 1988-02-03 1988-02-03
US20819288A 1988-06-16 1988-06-16

Publications (2)

Publication Number Publication Date
DE68901781D1 DE68901781D1 (de) 1992-07-23
DE68901781T2 true DE68901781T2 (de) 1993-01-07

Family

ID=26848957

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989870019T Expired - Fee Related DE68901781T2 (de) 1988-02-03 1989-02-01 Enzymsubstrate auf der basis neuer fettsaeureanaloge.

Country Status (5)

Country Link
US (2) US5871954A (de)
EP (1) EP0327523B1 (de)
JP (1) JPH021425A (de)
CA (1) CA1339220C (de)
DE (1) DE68901781T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151445A (en) * 1988-02-03 1992-09-29 Washington University Method of inhibiting parasitic activity
US5082967A (en) * 1988-06-16 1992-01-21 Washington University Novel fatty acid analog enzyme substrates
ATE139524T1 (de) * 1990-10-12 1996-07-15 Univ Washington Azido-substituierte fettsäuren als enzymsubstratanaloge
US5236955A (en) * 1992-04-10 1993-08-17 Washington University Anti-fungal agent
US5599947A (en) * 1993-01-14 1997-02-04 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
JP2003514855A (ja) * 1999-10-13 2003-04-22 チャコン，マルコ，エー． カロリー制限の効果を模倣した治療的介入
BRPI1014538A2 (pt) * 2009-05-04 2016-04-05 Univ Washington radiotraçadores pet para imagear metabolismo e armazenamento de ácido graxo
WO2017175522A1 (ja) * 2016-04-05 2017-10-12 株式会社Moresco オキサ酸化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE745312C (de) * 1941-10-17 1944-03-31 Ig Farbenindustrie Ag Verfahren zur Herstellung von Estern veraetherter aliphatischer Oxycarbonsaeuren
US4740588A (en) * 1986-08-07 1988-04-26 Washington University Novel substrate peptides
US4709012A (en) * 1986-08-07 1987-11-24 Washington University Novel inhibitor peptides
US5093517A (en) * 1987-03-09 1992-03-03 The Goodyear Tire & Rubber Company Method for the esterification of thiopropionates

Also Published As

Publication number Publication date
DE68901781D1 (de) 1992-07-23
EP0327523B1 (de) 1992-06-17
CA1339220C (en) 1997-08-05
EP0327523A1 (de) 1989-08-09
JPH021425A (ja) 1990-01-05
US5959145A (en) 1999-09-28
US5871954A (en) 1999-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: RESEARCH CORPORATION TECHNOLOGIES, INC. (N.D.GES.D

8328 Change in the person/name/address of the agent

Free format text: HOFFMANN * EITLE, 81925 MUENCHEN

8339 Ceased/non-payment of the annual fee