ATE102630T1 - Aminosaeuren und peptide mit einem modifizierten tyrosin, ihre herstellung und ihre verwendung als medikamente. - Google Patents
Aminosaeuren und peptide mit einem modifizierten tyrosin, ihre herstellung und ihre verwendung als medikamente.Info
- Publication number
- ATE102630T1 ATE102630T1 AT89402164T AT89402164T ATE102630T1 AT E102630 T1 ATE102630 T1 AT E102630T1 AT 89402164 T AT89402164 T AT 89402164T AT 89402164 T AT89402164 T AT 89402164T AT E102630 T1 ATE102630 T1 AT E102630T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- amino
- amino acids
- medications
- peptides
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical class OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000008991 intestinal motility Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8810391A FR2634763B1 (fr) | 1988-08-01 | 1988-08-01 | Amino-acides et peptides presentant un residu tyrosine modifiee, leur preparation et leur application comme medicaments |
| EP89402164A EP0354108B1 (de) | 1988-08-01 | 1989-07-28 | Aminosäuren und Peptide mit einem modifizierten Tyrosin, ihre Herstellung und ihre Verwendung als Medikamente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE102630T1 true ATE102630T1 (de) | 1994-03-15 |
Family
ID=9369006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89402164T ATE102630T1 (de) | 1988-08-01 | 1989-07-28 | Aminosaeuren und peptide mit einem modifizierten tyrosin, ihre herstellung und ihre verwendung als medikamente. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5190921A (de) |
| EP (1) | EP0354108B1 (de) |
| JP (1) | JPH0288555A (de) |
| AT (1) | ATE102630T1 (de) |
| CA (1) | CA1331499C (de) |
| DE (1) | DE68913618T2 (de) |
| ES (1) | ES2052045T3 (de) |
| FR (1) | FR2634763B1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475129A (en) * | 1991-09-30 | 1995-12-12 | The United States Of America As Represented By The Department Of Health And Human Services | Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis |
| US5200546A (en) * | 1991-09-30 | 1993-04-06 | The United States Of America As Represented By The Department Of Health And Human Services | Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis |
| US5489717A (en) * | 1994-07-08 | 1996-02-06 | Warner-Lambert Company | Glutamate (NMDA) receptor antagonists |
| US5922697A (en) * | 1996-10-02 | 1999-07-13 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins |
| FR2823212B1 (fr) * | 2001-04-10 | 2005-12-02 | Inst Nat Sante Rech Med | Inhibiteurs de la toxine botulique de type b |
| FR2931151A1 (fr) * | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ218607A (en) * | 1985-12-19 | 1989-10-27 | Pennwalt Corp | Tri-to acta-peptides with sulphate ester groups: obesity treatment |
| US4657899A (en) * | 1986-04-09 | 1987-04-14 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors |
| GB8625941D0 (en) * | 1986-10-30 | 1986-12-03 | Sandoz Ltd | Substituted alpha-amino acids |
| JPS63198699A (ja) * | 1986-11-18 | 1988-08-17 | ファイゾンス・コーポレイション | スルフエートエステル基を有するペプチド |
| IL84478A0 (en) * | 1986-11-18 | 1988-04-29 | Pennwalt Corp | Peptides with sulfate ester groups and their preparation |
| US4918064A (en) * | 1987-10-21 | 1990-04-17 | G. D. Searle & Co. | Phenyl glycines for use in reducing neurotoxic injury |
-
1988
- 1988-08-01 FR FR8810391A patent/FR2634763B1/fr not_active Expired - Lifetime
-
1989
- 1989-07-21 CA CA000606362A patent/CA1331499C/en not_active Expired - Fee Related
- 1989-07-28 DE DE68913618T patent/DE68913618T2/de not_active Expired - Fee Related
- 1989-07-28 AT AT89402164T patent/ATE102630T1/de not_active IP Right Cessation
- 1989-07-28 EP EP89402164A patent/EP0354108B1/de not_active Expired - Lifetime
- 1989-07-28 ES ES89402164T patent/ES2052045T3/es not_active Expired - Lifetime
- 1989-08-01 JP JP1200148A patent/JPH0288555A/ja active Pending
-
1992
- 1992-01-24 US US07/825,294 patent/US5190921A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE68913618D1 (de) | 1994-04-14 |
| US5190921A (en) | 1993-03-02 |
| JPH0288555A (ja) | 1990-03-28 |
| FR2634763A1 (fr) | 1990-02-02 |
| EP0354108B1 (de) | 1994-03-09 |
| FR2634763B1 (fr) | 1991-07-12 |
| ES2052045T3 (es) | 1994-07-01 |
| DE68913618T2 (de) | 1994-10-13 |
| CA1331499C (en) | 1994-08-16 |
| EP0354108A1 (de) | 1990-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |