ES2052045T3 - Aminoacidos y peptidos que presentan un residuo de tirosina modificado, su preparacion y su aplicacion como medicamentos. - Google Patents

Aminoacidos y peptidos que presentan un residuo de tirosina modificado, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2052045T3
ES2052045T3 ES89402164T ES89402164T ES2052045T3 ES 2052045 T3 ES2052045 T3 ES 2052045T3 ES 89402164 T ES89402164 T ES 89402164T ES 89402164 T ES89402164 T ES 89402164T ES 2052045 T3 ES2052045 T3 ES 2052045T3
Authority
ES
Spain
Prior art keywords
alkyl
amino
amino acids
residue
thyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89402164T
Other languages
English (en)
Inventor
Bernard Pierre Roques
Isabelle Marseigne
Bruno Charpentier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Application granted granted Critical
Publication of ES2052045T3 publication Critical patent/ES2052045T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTOS COMPUESTOS ESTAN REPRESENTADOS POR LA FORMULA (I), DONDE R1 Y R2 = H, ALQUILO C1-C8, CICLOALQUILO C3-C7 O AROMATICO; CUANDO R1 = H, R2 PUEDE SER RADICAL PROTECTOR DE FUNCION AMINA, GRUPO AMINOACIDO O FRAGMENTO PEPTIDICO; R1 Y R2 PUEDEN FORMAR CON NITROGENO UN CICLO DE 5-7 MIEMBROS; A = CARBONILO O METILENO; W = HIDROXI, FENOXI, ALCOXI C1-C8, FENOXI(ALQUILO C1-C8), AMINO, (ALQUIL C1-C8)-AMINO, DI-(ALQUIL C1-C8)-AMINO, (CUANDO A = CARBONILO, W = GRUPO AMINOACIDO O FRAGMENTO PEPTIDICO); Y = -OSO2OR3 (II), OPO(OR3)2 (III), -(CH2)MSO2OR3 (IV) O -(CH2)M-PO(OR3) (V) [R3 = H, ALQUILO C1-C8; M = 1-4]; Z = CICLOHEXANO, PIRIDILO O FENILO; N = 0-4; CON LA CONDICION DE QUE SI H = (II) O (III), -A-W ES DISTINTO DE UNA SECUENCIA COMPUESTA DE AMINOACIDOS NATURALES. TIENEN PROPIEDADES ANTIPSICOTICAS, UN EFECTO QUE FACILITA LOS PROCESOS DE MEMORIZACION, PROPIEDADES ANALGESICAS, SON UTILES COMO ANOREXICOS, Y TIENEN EFECTOS ESTIMULANTES DE LA MOTILIDAD INTESTINAL.
ES89402164T 1988-08-01 1989-07-28 Aminoacidos y peptidos que presentan un residuo de tirosina modificado, su preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2052045T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8810391A FR2634763B1 (fr) 1988-08-01 1988-08-01 Amino-acides et peptides presentant un residu tyrosine modifiee, leur preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ES2052045T3 true ES2052045T3 (es) 1994-07-01

Family

ID=9369006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89402164T Expired - Lifetime ES2052045T3 (es) 1988-08-01 1989-07-28 Aminoacidos y peptidos que presentan un residuo de tirosina modificado, su preparacion y su aplicacion como medicamentos.

Country Status (8)

Country Link
US (1) US5190921A (es)
EP (1) EP0354108B1 (es)
JP (1) JPH0288555A (es)
AT (1) ATE102630T1 (es)
CA (1) CA1331499C (es)
DE (1) DE68913618T2 (es)
ES (1) ES2052045T3 (es)
FR (1) FR2634763B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475129A (en) * 1991-09-30 1995-12-12 The United States Of America As Represented By The Department Of Health And Human Services Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
US5200546A (en) * 1991-09-30 1993-04-06 The United States Of America As Represented By The Department Of Health And Human Services Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
US5489717A (en) * 1994-07-08 1996-02-06 Warner-Lambert Company Glutamate (NMDA) receptor antagonists
US5922697A (en) * 1996-10-02 1999-07-13 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ218607A (en) * 1985-12-19 1989-10-27 Pennwalt Corp Tri-to acta-peptides with sulphate ester groups: obesity treatment
US4657899A (en) * 1986-04-09 1987-04-14 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors
GB8625941D0 (en) * 1986-10-30 1986-12-03 Sandoz Ltd Substituted alpha-amino acids
JPS63198699A (ja) * 1986-11-18 1988-08-17 ファイゾンス・コーポレイション スルフエートエステル基を有するペプチド
IL84478A0 (en) * 1986-11-18 1988-04-29 Pennwalt Corp Peptides with sulfate ester groups and their preparation
US4918064A (en) * 1987-10-21 1990-04-17 G. D. Searle & Co. Phenyl glycines for use in reducing neurotoxic injury

Also Published As

Publication number Publication date
ATE102630T1 (de) 1994-03-15
DE68913618D1 (de) 1994-04-14
US5190921A (en) 1993-03-02
JPH0288555A (ja) 1990-03-28
FR2634763A1 (fr) 1990-02-02
EP0354108B1 (fr) 1994-03-09
FR2634763B1 (fr) 1991-07-12
DE68913618T2 (de) 1994-10-13
CA1331499C (en) 1994-08-16
EP0354108A1 (fr) 1990-02-07

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