ATA2732004A - Verfahren zur herstellung von anagrelid hydrochlorid - Google Patents

Verfahren zur herstellung von anagrelid hydrochlorid

Info

Publication number
ATA2732004A
ATA2732004A AT0027304A AT2732004A ATA2732004A AT A2732004 A ATA2732004 A AT A2732004A AT 0027304 A AT0027304 A AT 0027304A AT 2732004 A AT2732004 A AT 2732004A AT A2732004 A ATA2732004 A AT A2732004A
Authority
AT
Austria
Prior art keywords
anagrelid
hydrochloride
preparing
preparing anagrelid
anagrelid hydrochloride
Prior art date
Application number
AT0027304A
Other languages
English (en)
Other versions
AT412873B (de
Original Assignee
Aop Orphan Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aop Orphan Pharmaceuticals Ag filed Critical Aop Orphan Pharmaceuticals Ag
Priority to AT0027304A priority Critical patent/AT412873B/de
Publication of ATA2732004A publication Critical patent/ATA2732004A/de
Priority to PCT/AT2005/000032 priority patent/WO2005080398A1/de
Application granted granted Critical
Publication of AT412873B publication Critical patent/AT412873B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0027304A 2004-02-20 2004-02-20 Verfahren zur herstellung von anagrelid hydrochlorid AT412873B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT0027304A AT412873B (de) 2004-02-20 2004-02-20 Verfahren zur herstellung von anagrelid hydrochlorid
PCT/AT2005/000032 WO2005080398A1 (de) 2004-02-20 2005-02-03 Verfahren zur herstellung von anagrelid hydrochlorid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0027304A AT412873B (de) 2004-02-20 2004-02-20 Verfahren zur herstellung von anagrelid hydrochlorid

Publications (2)

Publication Number Publication Date
ATA2732004A true ATA2732004A (de) 2005-01-15
AT412873B AT412873B (de) 2005-08-25

Family

ID=33569153

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0027304A AT412873B (de) 2004-02-20 2004-02-20 Verfahren zur herstellung von anagrelid hydrochlorid

Country Status (2)

Country Link
AT (1) AT412873B (de)
WO (1) WO2005080398A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
AR064106A1 (es) 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
CN101463035A (zh) * 2007-12-19 2009-06-24 华生制药私人有限公司 生产盐酸阿那格雷一水合物的改进方法
CN102757434B (zh) * 2012-08-07 2014-06-04 黑龙江天宏药业股份有限公司 一种用于工业化放大生产盐酸阿那格雷原料药的制备方法
CN103254197A (zh) * 2013-05-29 2013-08-21 黑龙江大学 一种盐酸阿那格雷的制备方法
CN107903269B (zh) * 2017-11-16 2021-05-04 湖北省宏源药业科技股份有限公司 一种阿那格雷三氯衍生物的制备方法
CN110590680B (zh) * 2019-09-20 2023-05-16 深圳市祥根生物医药有限公司 一种阿那格雷开环甲酯化杂质的制备方法
CN111072575A (zh) * 2019-12-28 2020-04-28 深圳市祥根生物科技有限公司 一种阿那格雷杂质c的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
US4208521A (en) * 1978-07-31 1980-06-17 Bristol-Myers Company Process for the preparation of imidazo[2,1-b]quinazolinones
US5391737A (en) * 1991-05-22 1995-02-21 Egis Gyogyszergyar Process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one
HU206496B (en) * 1991-05-22 1992-11-30 Egyt Gyogyszervegyeszeti Gyar Process for producing 2,3-dichloro-6-nitro-benzonitril
HU207713B (en) * 1991-05-22 1993-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 2,3-dichloro-6-amino-benzene derivatives
JPH05271200A (ja) * 1991-05-22 1993-10-19 Egyt Gyogyszervegyeszeti Gyar ６，７−ジクロロ−１，５−ジヒドロ−イミダゾ〔２，１−ｂ〕キナゾリン−２〔３Ｈ〕−オンの製造方法
HU213619B (en) * 1992-04-10 1997-08-28 Egyt Gyogyszervegyeszeti Gyar Process for producing quinolinyl acetic acid esters
CA2171073A1 (en) * 1995-12-04 1997-06-05 Philip C. Lang Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
US20030114673A1 (en) * 2002-05-29 2003-06-19 Lang Philip C. 2-amino-5,6-dihalo-3,4-dihydroquinazolines with blood platelet reducing properties

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count

Also Published As

Publication number Publication date
AT412873B (de) 2005-08-25
WO2005080398A1 (de) 2005-09-01

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Legal Events

Date Code Title Description
HC Change of the firm name or firm address

Owner name: AOP ORPHAN PHARMACEUTICALS GMBH, AT

Effective date: 20220125

MK07 Expiry

Effective date: 20240220