ATA2732004A - Verfahren zur herstellung von anagrelid hydrochlorid - Google Patents
Verfahren zur herstellung von anagrelid hydrochloridInfo
- Publication number
- ATA2732004A ATA2732004A AT0027304A AT2732004A ATA2732004A AT A2732004 A ATA2732004 A AT A2732004A AT 0027304 A AT0027304 A AT 0027304A AT 2732004 A AT2732004 A AT 2732004A AT A2732004 A ATA2732004 A AT A2732004A
- Authority
- AT
- Austria
- Prior art keywords
- anagrelid
- hydrochloride
- preparing
- preparing anagrelid
- anagrelid hydrochloride
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0027304A AT412873B (de) | 2004-02-20 | 2004-02-20 | Verfahren zur herstellung von anagrelid hydrochlorid |
PCT/AT2005/000032 WO2005080398A1 (de) | 2004-02-20 | 2005-02-03 | Verfahren zur herstellung von anagrelid hydrochlorid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0027304A AT412873B (de) | 2004-02-20 | 2004-02-20 | Verfahren zur herstellung von anagrelid hydrochlorid |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA2732004A true ATA2732004A (de) | 2005-01-15 |
AT412873B AT412873B (de) | 2005-08-25 |
Family
ID=33569153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0027304A AT412873B (de) | 2004-02-20 | 2004-02-20 | Verfahren zur herstellung von anagrelid hydrochlorid |
Country Status (2)
Country | Link |
---|---|
AT (1) | AT412873B (de) |
WO (1) | WO2005080398A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7910597B2 (en) | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
AR064106A1 (es) | 2006-12-05 | 2009-03-11 | Bayer Schering Pharma Ag | Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis |
CN101463035A (zh) * | 2007-12-19 | 2009-06-24 | 华生制药私人有限公司 | 生产盐酸阿那格雷一水合物的改进方法 |
CN102757434B (zh) * | 2012-08-07 | 2014-06-04 | 黑龙江天宏药业股份有限公司 | 一种用于工业化放大生产盐酸阿那格雷原料药的制备方法 |
CN103254197A (zh) * | 2013-05-29 | 2013-08-21 | 黑龙江大学 | 一种盐酸阿那格雷的制备方法 |
CN107903269B (zh) * | 2017-11-16 | 2021-05-04 | 湖北省宏源药业科技股份有限公司 | 一种阿那格雷三氯衍生物的制备方法 |
CN110590680B (zh) * | 2019-09-20 | 2023-05-16 | 深圳市祥根生物医药有限公司 | 一种阿那格雷开环甲酯化杂质的制备方法 |
CN111072575A (zh) * | 2019-12-28 | 2020-04-28 | 深圳市祥根生物科技有限公司 | 一种阿那格雷杂质c的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
US4208521A (en) * | 1978-07-31 | 1980-06-17 | Bristol-Myers Company | Process for the preparation of imidazo[2,1-b]quinazolinones |
JPH05271200A (ja) * | 1991-05-22 | 1993-10-19 | Egyt Gyogyszervegyeszeti Gyar | 6,7−ジクロロ−1,5−ジヒドロ−イミダゾ〔2,1−b〕キナゾリン−2〔3H〕−オンの製造方法 |
HU207713B (en) * | 1991-05-22 | 1993-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 2,3-dichloro-6-amino-benzene derivatives |
US5391737A (en) * | 1991-05-22 | 1995-02-21 | Egis Gyogyszergyar | Process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one |
HU206496B (en) * | 1991-05-22 | 1992-11-30 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 2,3-dichloro-6-nitro-benzonitril |
HU213619B (en) * | 1992-04-10 | 1997-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing quinolinyl acetic acid esters |
CA2171073A1 (en) * | 1995-12-04 | 1997-06-05 | Philip C. Lang | Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine |
US6388073B1 (en) * | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
US20030114673A1 (en) * | 2002-05-29 | 2003-06-19 | Lang Philip C. | 2-amino-5,6-dihalo-3,4-dihydroquinazolines with blood platelet reducing properties |
-
2004
- 2004-02-20 AT AT0027304A patent/AT412873B/de not_active IP Right Cessation
-
2005
- 2005-02-03 WO PCT/AT2005/000032 patent/WO2005080398A1/de active Application Filing
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
Also Published As
Publication number | Publication date |
---|---|
AT412873B (de) | 2005-08-25 |
WO2005080398A1 (de) | 2005-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of the firm name or firm address |
Owner name: AOP ORPHAN PHARMACEUTICALS GMBH, AT Effective date: 20220125 |
|
MK07 | Expiry |
Effective date: 20240220 |