AT52845B - Process for the preparation of bromine diethyl acetylurea. - Google Patents

Process for the preparation of bromine diethyl acetylurea.

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Publication number
AT52845B
AT52845B AT52845DA AT52845B AT 52845 B AT52845 B AT 52845B AT 52845D A AT52845D A AT 52845DA AT 52845 B AT52845 B AT 52845B
Authority
AT
Austria
Prior art keywords
water
acetylurea
preparation
hours
bromine
Prior art date
Application number
Other languages
German (de)
Original Assignee
Farbenfab Vorm Bayer F & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farbenfab Vorm Bayer F & Co filed Critical Farbenfab Vorm Bayer F & Co
Application granted granted Critical
Publication of AT52845B publication Critical patent/AT52845B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von   Bromdiäthylazetylharnstoff.   Es wurde gefunden, dass der Bromdiäthylazetylharnstoff der Formel : 
 EMI1.1 
 wertvolle therapeutische Eigenschaften besitzt Er ist ein kristallinischer, geruch-und geschmackloser Körper. Da er vom Magen sehr gut vertragen wird und den Appetit nicht beeinflusst, hat sich das neue Produkt als wertvolles Sedativum erwiesen. 



   Es übertritt in dieser Beziehung die Produkte der D. R. P. Nr. 158220 und 185962.
Zur Darstellung der neuen Verbindung verfährt man in der Weise, dass man Bromdiäthylazetylhaloide auf Harnstoff einwirken lässt. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of bromine diethyl acetylurea. It has been found that the bromine diethyl acetylurea of the formula:
 EMI1.1
 It has valuable therapeutic properties. It is a crystalline, odorless and tasteless body. Since it is very well tolerated by the stomach and does not affect the appetite, the new product has proven to be a valuable sedative.



   In this respect it transgresses the products of D. R. P. Nos. 158220 and 185962.
To prepare the new compound one proceeds in such a way that one lets bromodiethylazetylhaloide act on urea.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

Beispiel : 120 Teile Harnstoff werden mit 258 Teilen Bromdiäthylazetylbromid EMI1.2 12stündigem Stehen etwa 3 Stunden auf dem Wasserbad erwärmt. Das Reaktionsprodukt wird nach dem Erkalten gut zerkleinert und mit Wasser und so viel Natriumbikarl) onat verrührt, dass eben alkalische Reaktion eintritt. Unverändertes Ausgangsmaterial geht in die wassrigo Brühe über, die abgesaugt wird. Der in Wasser unlösliche Teil wird durch Um- kristallisieren aus verdünntem Alkohol gereinigt. Der Bromdiäthylazetylharnstoff EMI1.3 bildet farblose, geschmack- und geruchlose Kristalle, die unscharf bei etwa 114 bis 1180 C schmelzen. Sie lösen sich sehr wenig in kaltem Wasser, in Petrolätther und Ligroin sind six ziemlich schwer löslich, in Alkohol und Azeton leicht löslich. Example: 120 parts of urea are mixed with 258 parts of bromine diethyl acetyl bromide EMI1.2 Standing for 12 hours on the water bath for about 3 hours. After cooling, the reaction product is comminuted well and mixed with water and so much sodium bicarbonate that an alkaline reaction occurs. Unchanged starting material goes into the wassrigo broth, which is sucked off. The part which is insoluble in water is purified by recrystallization from dilute alcohol. The bromine diethyl acetylurea EMI1.3 forms colorless, tasteless and odorless crystals that melt out of focus at around 114 to 1180 C. They dissolve very little in cold water, six are rather sparingly soluble in petroleum ether and ligroin, and easily soluble in alcohol and acetone. Mit Natronlauge wird der Körper gespalten unter Abgabe von Ammoniak. i'ATENT-AXMPRn'H : Verfahren zur Darstellung von Bromdiäthylazetylharnstoff, darin bestehend, dass man Bromdiathylazetylhaloide auf Harnstoff einwirken lässt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. The body is split with caustic soda, releasing ammonia. i'ATENT-AXMPRn'H: Process for the preparation of bromodiethylazetylurea, which consists in allowing urea to act on bromodiethylazetyl halides. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT52845D 1909-07-09 1910-06-06 Process for the preparation of bromine diethyl acetylurea. AT52845B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE52845X 1909-07-09

Publications (1)

Publication Number Publication Date
AT52845B true AT52845B (en) 1912-03-26

Family

ID=5627444

Family Applications (3)

Application Number Title Priority Date Filing Date
AT52845D AT52845B (en) 1909-07-09 1910-06-06 Process for the preparation of bromine diethyl acetylurea.
AT64862D AT64862B (en) 1909-07-09 1912-10-07 Process for the preparation of α-bromo diethyl acetylurea.
AT71255D AT71255B (en) 1909-07-09 1914-04-22 Method for the preparation of bromine diethyl acetyl carbamide.

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT64862D AT64862B (en) 1909-07-09 1912-10-07 Process for the preparation of α-bromo diethyl acetylurea.
AT71255D AT71255B (en) 1909-07-09 1914-04-22 Method for the preparation of bromine diethyl acetyl carbamide.

Country Status (1)

Country Link
AT (3) AT52845B (en)

Also Published As

Publication number Publication date
AT64862B (en) 1914-05-11
AT71255B (en) 1916-02-25

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