AT351565B - Verfahren zur herstellung von neuen chromogenen enzymsubstraten - Google Patents

Verfahren zur herstellung von neuen chromogenen enzymsubstraten

Info

Publication number
AT351565B
AT351565B AT900775A AT900775A AT351565B AT 351565 B AT351565 B AT 351565B AT 900775 A AT900775 A AT 900775A AT 900775 A AT900775 A AT 900775A AT 351565 B AT351565 B AT 351565B
Authority
AT
Austria
Prior art keywords
enzyme substrates
producing new
chromogenic enzyme
new chromogenic
producing
Prior art date
Application number
AT900775A
Other languages
German (de)
English (en)
Other versions
ATA900775A (de
Inventor
Leif Erik Aurell
Karl Goeran Claeson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of ATA900775A publication Critical patent/ATA900775A/de
Application granted granted Critical
Publication of AT351565B publication Critical patent/AT351565B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT900775A 1974-12-05 1975-11-27 Verfahren zur herstellung von neuen chromogenen enzymsubstraten AT351565B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7415229A SE407058B (sv) 1974-12-05 1974-12-05 Nya kromogena enzymsubstrat for serinproteaser

Publications (2)

Publication Number Publication Date
ATA900775A ATA900775A (de) 1978-03-15
AT351565B true AT351565B (de) 1979-08-10

Family

ID=20322900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT900775A AT351565B (de) 1974-12-05 1975-11-27 Verfahren zur herstellung von neuen chromogenen enzymsubstraten

Country Status (23)

Country Link
US (2) US4028318A (US06350818-20020226-C00016.png)
JP (1) JPS5431397B2 (US06350818-20020226-C00016.png)
AT (1) AT351565B (US06350818-20020226-C00016.png)
BE (1) BE836085A (US06350818-20020226-C00016.png)
CA (1) CA1048998A (US06350818-20020226-C00016.png)
CH (1) CH619983A5 (US06350818-20020226-C00016.png)
CS (1) CS187492B2 (US06350818-20020226-C00016.png)
DD (1) DD123316A5 (US06350818-20020226-C00016.png)
DE (1) DE2552570C3 (US06350818-20020226-C00016.png)
DK (1) DK145461C (US06350818-20020226-C00016.png)
ES (1) ES442997A1 (US06350818-20020226-C00016.png)
FI (1) FI753246A (US06350818-20020226-C00016.png)
FR (1) FR2293439A1 (US06350818-20020226-C00016.png)
GB (1) GB1488987A (US06350818-20020226-C00016.png)
HU (1) HU174263B (US06350818-20020226-C00016.png)
IL (1) IL48506A (US06350818-20020226-C00016.png)
IT (1) IT1052318B (US06350818-20020226-C00016.png)
NL (1) NL188648C (US06350818-20020226-C00016.png)
NO (1) NO142074C (US06350818-20020226-C00016.png)
PL (1) PL99020B1 (US06350818-20020226-C00016.png)
SE (1) SE407058B (US06350818-20020226-C00016.png)
SU (1) SU957762A3 (US06350818-20020226-C00016.png)
ZA (1) ZA757441B (US06350818-20020226-C00016.png)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4176009A (en) * 1976-01-24 1979-11-27 Ajinomoto Co., Inc. Method of measuring collagenase activity
SE431201B (sv) * 1976-01-24 1984-01-23 Ajinomoto Kk For anvendning vid metning av kollagenasaktivitet avsett peptidderivat jemte forfarande for nemnda metning
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
SE437153B (sv) * 1976-12-01 1985-02-11 Kabi Ab Specifika kromogena enzymsubstrat for serinproteaser
US4191809A (en) * 1977-02-26 1980-03-04 Ajinomoto Co., Inc. Method of measuring enzymatic activity using novel peptide derivatives
JPS5415797A (en) * 1977-06-14 1979-02-05 Seikagaku Kogyo Co Ltd Detection and measurement of toxin in cells
CA1087075A (en) * 1977-08-05 1980-10-07 Robert J. Gargiulo Composition and method for determining transferase and protease activity
US4438029A (en) 1978-01-19 1984-03-20 Research Corporation Synthetic peptides
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
FR2455083A1 (fr) * 1979-04-24 1980-11-21 Jozefonvicz Marcel Nouveau procede de dosage des proteases et des antiproteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE2921216A1 (de) * 1979-05-25 1980-12-04 Teschemacher Hansjoerg Pharmakologisch aktive peptide
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
US4244865A (en) * 1979-12-03 1981-01-13 Abbott Laboratories α hydroxy tripeptide substrates
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
US4301245A (en) * 1980-05-29 1981-11-17 Dynasciences Corporation Chromogenic method of detecting endotoxins in blood
DE3164437D1 (en) * 1980-08-25 1984-08-02 Kabivitrum Ab Peptide substrates for determination of protease activity
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
JPS5753445A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide compound
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
CA1247086A (en) * 1982-02-17 1988-12-20 Francis R. Pfeiffer Renally active tetrapeptides
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE3312191A1 (de) * 1983-04-02 1984-10-11 Karl Mengele & Söhne Maschinenfabrik und Eisengießerei GmbH & Co, 8870 Günzburg Schutzvorrichtung fuer mechanische schraenke und dergleichen geraete bzw. maschinen
FR2546164B1 (fr) * 1983-05-16 1987-07-17 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
DE3446714A1 (de) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
GB2492104A (en) * 2011-06-22 2012-12-26 Job Harenberg Assay for direct thrombin inhibitors
CN108089006B (zh) * 2016-11-23 2020-09-25 舒泰神（北京）生物制药股份有限公司 凝血因子ⅹ激活剂活性标定的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042487A (en) * 1964-06-25 1966-09-14 Ici Ltd Polypeptide derivatives
US3778426A (en) * 1970-12-16 1973-12-11 Research Corp Therapeutically useful polypeptides
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser

Also Published As

Publication number Publication date
NL188648C (nl) 1992-08-17
HU174263B (hu) 1979-12-28
DE2552570C3 (de) 1983-11-17
GB1488987A (en) 1977-10-19
JPS5431397B2 (US06350818-20020226-C00016.png) 1979-10-06
CA1048998A (en) 1979-02-20
FR2293439A1 (fr) 1976-07-02
NO142074B (no) 1980-03-17
PL99020B1 (pl) 1978-06-30
NL7513505A (nl) 1976-06-09
DK549475A (da) 1976-06-06
BE836085A (fr) 1976-03-16
DE2552570A1 (de) 1976-06-10
DK145461B (da) 1982-11-22
DE2552570B2 (de) 1980-01-10
ZA757441B (en) 1976-11-24
US4028318A (en) 1977-06-07
DD123316A5 (US06350818-20020226-C00016.png) 1976-12-12
JPS5183595A (US06350818-20020226-C00016.png) 1976-07-22
DK145461C (da) 1983-04-18
CH619983A5 (US06350818-20020226-C00016.png) 1980-10-31
US4252715A (en) 1981-02-24
ES442997A1 (es) 1977-04-16
NL188648B (nl) 1992-03-16
SU957762A3 (ru) 1982-09-07
IT1052318B (it) 1981-06-20
NO142074C (no) 1980-06-25
IL48506A0 (en) 1976-01-30
IL48506A (en) 1979-05-31
ATA900775A (de) 1978-03-15
FR2293439B1 (US06350818-20020226-C00016.png) 1979-07-13
AU8687275A (en) 1977-06-02
SE7415229L (sv) 1976-06-08
CS187492B2 (en) 1979-01-31
FI753246A (US06350818-20020226-C00016.png) 1976-06-06
SE407058B (sv) 1979-03-12
NO753945L (US06350818-20020226-C00016.png) 1976-06-09

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Legal Events

Date Code Title Description
EIH Change in the person of patent owner
ELA Expired due to lapse of time
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties