AT26863B - Process for preparing concentrated solutions of thiosinamine. - Google Patents
Process for preparing concentrated solutions of thiosinamine.Info
- Publication number
- AT26863B AT26863B AT26863DA AT26863B AT 26863 B AT26863 B AT 26863B AT 26863D A AT26863D A AT 26863DA AT 26863 B AT26863 B AT 26863B
- Authority
- AT
- Austria
- Prior art keywords
- thiosinamine
- concentrated solutions
- preparing concentrated
- water
- solutions
- Prior art date
Links
- HTKFORQRBXIQHD-UHFFFAOYSA-N allylthiourea Chemical compound NC(=S)NCC=C HTKFORQRBXIQHD-UHFFFAOYSA-N 0.000 title description 7
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000000243 solution Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical compound [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung konzentrierter Lösungen von Thiosinamin.
In der Literatur findet sich überall die Angabe, dass das Thiosinamin leicht löslich in Wasser sei. In dieser Allgemeinheit ist aber die Behauptung nicht zutreffend, denn nur in heissem Wasser löst sich Thiosinamin in grossen Mengen auf, während es beim Erkalten fast quantitativ wieder auskristallisiert, da es in kaltem Wasser sehr schwer löslich ist.
Dies macht sich bei der Verwendung des Präparates zu subkutanen Injektionen als Übelstand geltend. Ilebra hat aus diesem Grunde eine 15%ige alkoholische Lösung vorgeschlagen. Die Injektionen mit dieser Lösung sind aber so schmerzhaft, dass eine langer ausgedehnte Behandlung, wie sie fast immer erforderlich ist, vollständig ausgeschlossen
EMI1.1
Losung in warmem Wasser und Glyzerin. Sie verursacht keine so grossen Schmerzen bei der Einspritzung, hat aber den Nachteil, dass sich nach kurzem Stehen wieder Thiosinamin aus ihr ausscheidet, so d.itss man für eine neue Injektion wieder erst erwärmen muss.
Dies öftere Erwärmen ist aber dem Thiosinamin nachteilig, indem dasselbe dadurch partiell zersetzt wird, wie aus dem starken Allylgeruch hervorgeht, welchen solche mehrfach erwärmte Lösungen zeigen. Dementsprechend ist auch von verschiedenen Seiten, insbcsonder ;-
EMI1.2
gar uicht schmerzhaft. Sie entspricht also auf das vollkommenste den Anforderungen der Praxis.
Ausserdem wirkt aber das salizylsaure Natron noch direkt schmerzstillend, so dass durch seine Anwendung ein doppelter Vorteil erreicht wird.
Die so hergestellten Lösungen sollen sterilisiert in zugeschmolzenen Gläschen in den Hände) gebracht werden.
Beispiel 1 : 1 Molekül Thiosinamin und ¸ Molekül salizylsaures Natrium werden in Wasser, Alkohol oder dgl. gelöst und eingedampft. Die zurückbleibende Masse stellt ein weisses kristallinisches Pulver dar, welches in Wasser auch in der Kälte sehr leicht
EMI1.3
salizylsauremNatrongibtdasgleicheResultat.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for preparing concentrated solutions of thiosinamine.
In the literature one can find everywhere the statement that thiosinamine is easily soluble in water. In this generality, however, the claim is not correct, because thiosinamine only dissolves in large quantities in hot water, while it crystallizes out again almost quantitatively when it cools, since it is very difficult to dissolve in cold water.
This makes itself felt as a nuisance when using the preparation for subcutaneous injections. For this reason, Ilebra proposed a 15% alcoholic solution. However, the injections with this solution are so painful that a long, extended treatment, which is almost always necessary, is completely ruled out
EMI1.1
Solution in warm water and glycerin. It does not cause that great pain during the injection, but has the disadvantage that thiosinamine is excreted from it again after standing for a short time, so that you have to warm up again for a new injection.
This frequent heating is disadvantageous for thiosinamine in that it is partially decomposed as a result, as can be seen from the strong allyl odor which such repeatedly heated solutions exhibit. Correspondingly, from different sides, especially special; -
EMI1.2
Not at all painful. It therefore corresponds perfectly to the requirements of practice.
In addition, however, the salicylic acid soda has a direct analgesic effect, so that its use has a double benefit.
The solutions produced in this way should be sterilized and brought into the hands in sealed vials.
Example 1: 1 molecule of thiosinamine and ¸ molecule of sodium salicylate are dissolved in water, alcohol or the like and evaporated. The remaining mass is a white crystalline powder, which is very light in water even in the cold
EMI1.3
Sodium salicylic acid gives the same result.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1904163804D DE163804C (en) | 1904-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT26863B true AT26863B (en) | 1906-12-27 |
Family
ID=5683856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT26863D AT26863B (en) | 1904-12-12 | 1905-09-06 | Process for preparing concentrated solutions of thiosinamine. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT26863B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005006950A1 (en) * | 2005-02-16 | 2006-08-24 | Nicolay, Stephan, Dipl.-Ing. | Transparent permanent/temporary roof for halls/arenas, using hollow chamber plate modules, has fasteners and carrier profiles to lock them together with rods at the carriers inserted into the hollow chambers |
-
1905
- 1905-09-06 AT AT26863D patent/AT26863B/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005006950A1 (en) * | 2005-02-16 | 2006-08-24 | Nicolay, Stephan, Dipl.-Ing. | Transparent permanent/temporary roof for halls/arenas, using hollow chamber plate modules, has fasteners and carrier profiles to lock them together with rods at the carriers inserted into the hollow chambers |
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