AT222999B - Process for the production of preparations containing or consisting of sodium and calcium cyclamate - Google Patents

Process for the production of preparations containing or consisting of sodium and calcium cyclamate

Info

Publication number
AT222999B
AT222999B AT342561A AT342561A AT222999B AT 222999 B AT222999 B AT 222999B AT 342561 A AT342561 A AT 342561A AT 342561 A AT342561 A AT 342561A AT 222999 B AT222999 B AT 222999B
Authority
AT
Austria
Prior art keywords
sodium
cyclamate
production
preparations containing
calcium
Prior art date
Application number
AT342561A
Other languages
German (de)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Application granted granted Critical
Publication of AT222999B publication Critical patent/AT222999B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

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  Verfahren zur Herstellung von Natrium- und Kalziumcyclamat enthaltenden oder daraus bestehenden Zubereitungen 
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   Mit den erfindungsgemäss hergestellten Mischungen lassen sich z. B. konzentrierte wässerige Lösungen herstellen, die eine Süsskraft besitzen, die bisher nur   z. B.   durch Zusatz von Saccharin mit dessen bekann- ten Nachteilen erreicht wurde. Dies schliesst hingegen nicht aus, dass den erfindungsgemässen Cyclamat- mischungen gegebenenfalls auch geringe Zusätze von andern künstlichen Süssstoffen und/oder diätetische i Süssmittel, z. B. Arabitoder Sorbit, letztere auch als Feuchtungsmittel, z. B. an Stelle von Glycerin, zu- gefügt werden können. 



   Zur Haltbarmachung von Zubereitungen, welche derartige Cyclamatgemische enthalten, können ausserdem Konservierungsmittel, wie Benzoesäure und/oder   p-Oxybenzoesäureester,     z. B.   deren Methyl- und Propylester, zugesetzt werden. 



   Erfindungsgemäss hergestellte   Mischungen von trockenem Natriumcyc1amat und kristallwasserhaltigem  
Kalziumcyclamat zeichnen sich ferner auch dadurch aus, dass dieselben sehr gut frei fliessend und nicht anhaftend sind und sich demzufolge in trockenem Zustande besonders leicht in technischem Massstabe ver- arbeiten lassen. 



   Derartige Cyclamatmischungen sind bei Zubereitungen aller Art von Vorteil, wo bestimmte Flüssig- keitsmengen vorhanden bzw. nicht überschritten werden sollen und wo die erfin dungsgemäss erzielte er- zielte erhöhte Löslichkeit,   z. B. zurbesseren Durchdringung von Kompottfrüchten,   eingemachten Früchten und Fruchtkonserven sowie in Tablettenmassen oder Sirupen, ferner allgemein zur Erzielung erhöhter
Süssstoffkonzentrationen, ausgenützt werden kann. 
 EMI2.1 
 ser gelöst. Beim Abkühlen auf zirka 20 tritt noch keine Kristallisation ein. 



   Beispiel4 :18,0gNatriumcyclamatund18,0gKalziumcyclamat.2H2Ooder16,5gKalziumcyclamat à 100% Trockengehalt sind in 98,5   cm3 bzw. l00 cm3   entionisiertem Wasser bei zirka   24    eben noch löslich. 



   Die Löslichkeit dieses Cyclamatgemisches ist um zirka 55% höher als diejenige der einzelnen Komponenten. 



   Beispiel 5 : 10, 0 g pulverisiertes Natriumcyclamat und 12, 0 g pulverisiertes   Kalziumcycla-      mat. 2H O (Trockengehalt 91, 7%)   werden homogen vermischt. Die erhaltene Mischung hat einen Trokkengehalt von 95, 45% und weist, auf einen Trockengehalt à 100% umgerechnet, im wichtigen Temperaturbereich von 00 bis +10  eine um zirka 45-40% erhöhte Löslichkeit, verglichen mit Natriumcyclamat auf.



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  Process for the production of preparations containing or consisting of sodium and calcium cyclamate
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   With the mixtures prepared according to the invention z. B. produce concentrated aqueous solutions that have a sweetness that so far only z. B. was achieved by adding saccharin with its known disadvantages. However, this does not rule out the fact that the cyclamate mixtures according to the invention may also contain small amounts of other artificial sweeteners and / or dietary sweeteners, e.g. B. arabitol or sorbitol, the latter also as a humectant, e.g. B. instead of glycerine, can be added.



   To preserve preparations which contain such cyclamate mixtures, preservatives such as benzoic acid and / or p-oxybenzoic acid ester, e.g. B. their methyl and propyl esters are added.



   Mixtures of dry sodium cycamate and water of crystallization containing mixtures prepared according to the invention
Calcium cyclamate is also distinguished by the fact that it flows very freely and does not adhere and can therefore be processed particularly easily on an industrial scale in the dry state.



   Such cyclamate mixtures are advantageous in preparations of all kinds where certain amounts of liquid are to be present or not to be exceeded and where the increased solubility achieved according to the invention, eg. B. for better penetration of compote fruits, canned fruits and canned fruits as well as in tablet masses or syrups, also generally to achieve increased
Sweetener concentrations, can be exploited.
 EMI2.1
 ser solved. When cooling to around 20, no crystallization occurs.



   Example 4: 18.0 g sodium cyclamate and 18.0 g calcium cyclamate. 2H2O or 16.5 g calcium cyclamate with a dry content of 100% are just soluble in 98.5 cm3 or 100 cm3 deionized water at around 24 hours.



   The solubility of this cyclamate mixture is around 55% higher than that of the individual components.



   Example 5: 10.0 g of powdered sodium cyclamate and 12.0 g of powdered calcium cyclamate. 2HO (dry content 91.7%) are mixed homogeneously. The mixture obtained has a dry content of 95.45% and, converted to a dry content of 100%, in the important temperature range from 00 to +10, has a solubility that is around 45-40% higher than that of sodium cyclamate.

 

Claims (1)

PA TENT ANSPRUCH : Verfahren zur Herstellung von Natrium- und Kalziumcyclamat (Natrium-und Kalziumsalz der N-Cyclohexylsulfaminsäure) enthaltenden oder daraus bestehenden Zubereitungen in fester Form oder in Form wässeriger Lösungen, dadurch gekennzeichnet, dass man die beiden Salze in solchen Mengenanteilen mischt, dass das Gewichtsverhältnis Natriumcyclamat : Kalziumcyclamat in den Zubereitungen 1 : 0, 2-1 : 4, vorzugsweise 1 : 0, 5 - 1 : 1,2 beträgt. PA TENT CLAIM: Process for the production of preparations containing or consisting of sodium and calcium cyclamate (sodium and calcium salt of N-cyclohexylsulfamic acid) in solid form or in the form of aqueous solutions, characterized in that the two salts are mixed in such proportions that the weight ratio of sodium cyclamate: Calcium cyclamate in the preparations is 1: 0, 2-1: 4, preferably 1: 0, 5-1: 1.2.
AT342561A 1960-05-03 1961-05-02 Process for the production of preparations containing or consisting of sodium and calcium cyclamate AT222999B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH222999X 1960-05-03

Publications (1)

Publication Number Publication Date
AT222999B true AT222999B (en) 1962-08-27

Family

ID=4452834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT342561A AT222999B (en) 1960-05-03 1961-05-02 Process for the production of preparations containing or consisting of sodium and calcium cyclamate

Country Status (1)

Country Link
AT (1) AT222999B (en)

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