AT208003B - Process for the preparation of iron-polyisomaltosate complexes - Google Patents

Process for the preparation of iron-polyisomaltosate complexes

Info

Publication number
AT208003B
AT208003B AT667758A AT667758A AT208003B AT 208003 B AT208003 B AT 208003B AT 667758 A AT667758 A AT 667758A AT 667758 A AT667758 A AT 667758A AT 208003 B AT208003 B AT 208003B
Authority
AT
Austria
Prior art keywords
iron
polyisomaltosate
solution
complex
water
Prior art date
Application number
AT667758A
Other languages
German (de)
Inventor
Arthur Dr Mueller
Theodor Dr Bersin
Original Assignee
Hausmann Ag Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hausmann Ag Labor filed Critical Hausmann Ag Labor
Priority to AT667758A priority Critical patent/AT208003B/en
Priority to ES0251613A priority patent/ES251613A1/en
Priority to BE581929A priority patent/BE581929A/en
Application granted granted Critical
Publication of AT208003B publication Critical patent/AT208003B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Herstellung von   Eisen-Polyisomaltosat-Komplexen   
 EMI1.1 
 

 <Desc/Clms Page number 2> 

    (III)-Polyisomaltosat-Komplexwasserstoffsäure,   neutralisiert werden. Nach der Oxydation kann die Eisenkomplex-Lösung dem Stand der Technik entsprechend von Nebenprodukten befreit werden. Gut wasserlösliche pulverförmige Präparate werden nach bekannten Verfahren durch schonendes Eindampfen der Lösungen oder durch Fällen mit einem geeigneten, wassermischbaren Lösungsmittel gewonnen. 



   Das erfindungsgemäss hergestellte Präparat liegt als gut wasserlösliches, hellbraunes, nicht hygroskopisches Pulver vor. Wird die Lösung tropfenweise mit   1- n HCI   unter Rühren versetzt, so tritt bei Raum- 
 EMI2.1 
 während 60 Minuten auf   650C   erwärmt und während des Abkühlens ein kräftiger Luftstrom durchgeleitet,   wobei die graugrüne Lösung eine rotbraun Farbe annahm. Das Reaktionsgemisch wurde durch Zentrifugieren von ungelösten Anteilen befreit, in die alkalische Lösung eine Mischung von 98 cm feuchtem, stark saurem Kationenaustauscher und 112 cm stark basischem Anionenaustauscher eingetragen, kurz   geschüttelt, die neutralisierte Lösung abfiltriert und mittels Vakuumdestillation soweit eingeengt, bis sie   5%   Eisen enthielt. 



   Beispiel 2 : Zu einer Lösung aus 50 cm Wasser und 25 g partiell depolymerisiertem Dextran ent- 
 EMI2.2 
    NaOHPATENTANSPRÜCHE   : 
1. Verfahren zur Herstellung eines therapeutisch verwendbaren   Eisen-Polyisomaltosat-Komplexes,   dadurch gekennzeichnet, dass man die Lösung eines wasserlöslichen Dextrans zusammen mit einer Lösung 
 EMI2.3 
 Komplex übergeführt wird.



   <Desc / Clms Page number 1>
 



  Process for the preparation of iron-polyisomaltosate complexes
 EMI1.1
 

 <Desc / Clms Page number 2>

    (III) polyisomaltosate complex hydrochloric acid. After the oxidation, the iron complex solution can be freed from by-products in accordance with the prior art. Preparations in powder form which are readily soluble in water are obtained by known processes by gently evaporating the solutions or by precipitating them with a suitable, water-miscible solvent.



   The preparation produced according to the invention is in the form of a readily water-soluble, light brown, non-hygroscopic powder. If the solution is mixed drop by drop with 1- n HCl with stirring, then at room temperature
 EMI2.1
 heated to 650 ° C. for 60 minutes and a vigorous stream of air was passed through it while cooling, the gray-green solution taking on a red-brown color. The reaction mixture was freed of undissolved components by centrifugation, a mixture of 98 cm of moist, strongly acidic cation exchanger and 112 cm of strongly basic anion exchanger was added to the alkaline solution, shaken briefly, the neutralized solution was filtered off and concentrated by vacuum distillation until it contained 5% iron contained.



   Example 2: To a solution of 50 cm of water and 25 g of partially depolymerized dextran,
 EMI2.2
    NaOH PATENT CLAIMS:
1. A process for the preparation of a therapeutically useful iron-polyisomaltosate complex, characterized in that the solution of a water-soluble dextran is combined with a solution
 EMI2.3
 Complex is transferred.

Claims (1)

2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, dass das wasserlösliche Dextran bei 250C eine Grundviskosität von 0, 025 bis 0, 1 aufweist. 2. The method according to claim 1, characterized in that the water-soluble dextran at 250C has a basic viscosity of 0.025 to 0.1. 3. Verfahren nach Anspruch l, dadurch gekennzeichnet, dass man das Dextran zuerst mit metallischem Eisen und Säure oder einer sauren Lösung eines zweiwertigen Eisensalzes solange erhitzt, bis es bei 250C eine Grundviskosität von 0,025 bis 0, 1 aufweist, wobei, ohne das Depolymerisationsprodukt zu isolieren, direkt nach Anspruch 1 mit Alkali behandelt und weiterverarbeitet wird. 3. The method according to claim l, characterized in that the dextran is first heated with metallic iron and acid or an acidic solution of a divalent iron salt until it has a basic viscosity of 0.025 to 0.1 at 250C, with, without the depolymerization product isolate, treated directly according to claim 1 with alkali and further processed. 4. Verfahren nach den Ansprüchen 1 und 3, dadurch gekennzeichnet, dass man zur Zurückdrängung der Hydrolyse des sauren Eisen- (II)-salzes Säure mit gleichem Anion wie im Eisen- (II)-salz zugibt. 4. Process according to Claims 1 and 3, characterized in that acid with the same anion as in the iron (II) salt is added to suppress the hydrolysis of the acidic iron (II) salt. 5. Verfahren nach den Ansprüchen 1 bis 4, dadurch gekennzeichnet, dass die Lösung des Eisen- Polyisomaltosat-Komplexes durch Dialyse gegen Wasser oder mit Hilfe von lonenaustauschern blutisotonisch gemacht wird. 5. The method according to claims 1 to 4, characterized in that the solution of the iron-polyisomaltosate complex is made blood isotonic by dialysis against water or with the aid of ion exchangers. 6. Verfahren nach den Ansprüchen 1 bis 11 zur Herstellung von festem Eisen-Polyisomaltosat-Komplex, dadurch gekennzeichnet, dass man die Lösung des Eisen-Polyisomaltosats im Vakuum eindampft oder den Komplex durch Zugabe eines geeigneten, mit Wasser mischbaren Lösungsmittels ausfällt, isoliert und trocknet. 6. Process according to claims 1 to 11 for the production of solid iron-polyisomaltosate complex, characterized in that the solution of the iron-polyisomaltosate is evaporated in vacuo or the complex is precipitated by adding a suitable water-miscible solvent, isolated and dried .
AT667758A 1958-09-23 1958-09-23 Process for the preparation of iron-polyisomaltosate complexes AT208003B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT667758A AT208003B (en) 1958-09-23 1958-09-23 Process for the preparation of iron-polyisomaltosate complexes
ES0251613A ES251613A1 (en) 1958-09-23 1959-08-11 Procedure for preparation of polyisomaltosa and iron complexes (Machine-translation by Google Translate, not legally binding)
BE581929A BE581929A (en) 1958-09-23 1959-08-22 Preparation of iron and polyisomaltose complexes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT667758A AT208003B (en) 1958-09-23 1958-09-23 Process for the preparation of iron-polyisomaltosate complexes

Publications (1)

Publication Number Publication Date
AT208003B true AT208003B (en) 1960-03-10

Family

ID=3588699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT667758A AT208003B (en) 1958-09-23 1958-09-23 Process for the preparation of iron-polyisomaltosate complexes

Country Status (3)

Country Link
AT (1) AT208003B (en)
BE (1) BE581929A (en)
ES (1) ES251613A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0543020A1 (en) * 1991-06-11 1993-05-26 Meito Sangyo Kabushiki Kaisha Oxidized composite comprising water-soluble carboxypolysaccharide and magnetic iron oxide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0543020A1 (en) * 1991-06-11 1993-05-26 Meito Sangyo Kabushiki Kaisha Oxidized composite comprising water-soluble carboxypolysaccharide and magnetic iron oxide
EP0543020A4 (en) * 1991-06-11 1993-12-01 Meito Sangyo Kabushiki Kaisha Oxidized composite comprising water-soluble carboxypolysaccharide and magnetic iron oxide

Also Published As

Publication number Publication date
BE581929A (en) 1960-12-16
ES251613A1 (en) 1959-12-16

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