AT144185B - Process for the preparation of non-flocculent solutions of proteinaceous medicinal products. - Google Patents

Process for the preparation of non-flocculent solutions of proteinaceous medicinal products.

Info

Publication number
AT144185B
AT144185B AT144185DA AT144185B AT 144185 B AT144185 B AT 144185B AT 144185D A AT144185D A AT 144185DA AT 144185 B AT144185 B AT 144185B
Authority
AT
Austria
Prior art keywords
preparation
solutions
proteinaceous
medicinal products
protein
Prior art date
Application number
Other languages
German (de)
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Application granted granted Critical
Publication of AT144185B publication Critical patent/AT144185B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur   Darstellung niehtfloekender Lösungen eiweisshaltiger Heilmittel.   



   Bekanntlich zeigen eiweisshaltige Lösungen die Eigenschaft, dass sie nicht dauernd klar bleiben. sondern zur Flockenbildung neigen, was auf Denaturierung des Eiweisses beruht. Dieser Umstand macht sich besonders bei therapeutischen Präparaten störend bemerkbar. 



   Es wurde nun gefunden, dass man die Flockung von eiweisshaltigen Lösungen von Heilmitteln aufheben oder weitgehend verhindern kann. indem man den eiweisshaltigen Lösungen höhermolekulare   Eiweissabbauprodukte,   insbesondere Säuren, wie Protalbinsäure. Lysalbinsäure usw. zugibt. Insbesondere sind die Salze dieser   Eiweissabbauprodukte,   besonders die Alkalisalze, wie z. B. die   Natrium-oder   Kalium- 
 EMI1.1 
 Stoffe den fertigen Lösungen zugibt. Mit gleichem Erfolge können die die Flockung verhindernden Stoffe auch in einer beliebigen Stufe des Fabrikationsprozesses der   eiweisshaltigen   Lösung zugesetzt werden. 



   Als   eiweisshaltige   Heilmittel kommen beispielsweise die Absonderungsprodukte von Drüsen in Frage, ferner Serumeiweissstoffe oder Eiweisskörper aus Krebsgeweben. Als höhermolekulare Abbauprodukte können verwendet werden Spaltprodukte, erhalten durch alkalischen Abbau des Eiweisses. ferner Peptone. erhalten durch enzymatischen Abbau, z. B. durch   Pepsinabbau.   



   Beispiele : 
 EMI1.2 
 etwa 1% protalbinsaurem Natrium unter Umrühren versetzt. Die Lösung zeigt nach dem Filtrieren keine Flockenbildung mehr. 



   2. Eine fraktionierte Thyreoglobin-Lösung wird auf die gewünschte Konzentration eingestellt und mit soviel protalbinsaurem Natrium versetzt, dass die Lösung etwa    10/00 davon   enthält. Die Lösung wird nunmehr mit Trikresol sterilisiert und durch Seitzfilter geklärt. 



   3. Trockenpulver von Insulin wird nach dem Ergebnis der Standardisierung mit Alkali-bzw. 



  Natriumalbuminat vermischt und die Substanz allmählich in der berechneten Menge sauren Wassers aufgelöst, so dass eine an Alkalialbuminat etwa   1#ige Lösung entsteht. Nach dem   Filtrieren erhält man eine beständige, keine Flocken bildende Lösung. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of non-flowing solutions of therapeutic products containing proteins.



   It is well known that solutions containing proteins have the property that they do not remain clear all the time. but tend to form flakes, which is based on denaturation of the protein. This fact is particularly noticeable with therapeutic preparations.



   It has now been found that the flocculation of protein-containing solutions of medicinal products can be eliminated or largely prevented. by adding higher molecular weight protein degradation products, in particular acids such as protalbic acid, to the protein-containing solutions. Lysalbinic acid, etc. adds. In particular, the salts of these protein degradation products, especially the alkali salts, such as. B. the sodium or potassium
 EMI1.1
 Adding substances to the finished solutions. The substances preventing flocculation can also be added to the protein-containing solution at any stage of the manufacturing process with the same success.



   As protein-containing remedies, for example, the secretion products of glands come into question, as well as serum proteins or protein bodies from cancerous tissues. Cleavage products obtained by alkaline degradation of the protein can be used as higher molecular weight degradation products. also peptones. obtained by enzymatic degradation, e.g. B. by pepsin degradation.



   Examples:
 EMI1.2
 about 1% sodium protalbinate is added while stirring. After filtering, the solution no longer shows any flake formation.



   2. A fractionated thyroglobin solution is adjusted to the desired concentration and so much protalbinate sodium is added that the solution contains about 10/00 of it. The solution is now sterilized with tricresol and clarified through a Seitz filter.



   3. Dry powder of insulin is according to the result of the standardization with alkali or.



  Sodium albuminate mixed and the substance gradually dissolved in the calculated amount of acidic water, so that a solution of about 1 # of alkali albuminate is formed. After filtering, a stable, non-flaky solution is obtained.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

 

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung nichtflockender Lösungen eiweisshaltiger Heilmittel, gekennzeichnet. durch einen Zusatz von höhermolekularen Eiweissabbauprodukten. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of non-flocculating solutions of therapeutic products containing protein, characterized. by adding higher molecular weight protein degradation products. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT144185D 1933-07-08 1934-06-28 Process for the preparation of non-flocculent solutions of proteinaceous medicinal products. AT144185B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE144185X 1933-07-08

Publications (1)

Publication Number Publication Date
AT144185B true AT144185B (en) 1935-12-27

Family

ID=5670089

Family Applications (1)

Application Number Title Priority Date Filing Date
AT144185D AT144185B (en) 1933-07-08 1934-06-28 Process for the preparation of non-flocculent solutions of proteinaceous medicinal products.

Country Status (1)

Country Link
AT (1) AT144185B (en)

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