AR241751A1 - Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter. - Google Patents

Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter.

Info

Publication number
AR241751A1
AR241751A1 AR89314371A AR31437189A AR241751A1 AR 241751 A1 AR241751 A1 AR 241751A1 AR 89314371 A AR89314371 A AR 89314371A AR 31437189 A AR31437189 A AR 31437189A AR 241751 A1 AR241751 A1 AR 241751A1
Authority
AR
Argentina
Prior art keywords
water
hydroalcoholic
gas
gangliosides
solvents
Prior art date
Application number
AR89314371A
Other languages
English (en)
Original Assignee
Beta Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beta Lab Sa filed Critical Beta Lab Sa
Priority to AR89314371A priority Critical patent/AR241751A1/es
Priority to EP19900307575 priority patent/EP0409473A3/en
Priority to BR909003470A priority patent/BR9003470A/pt
Priority to JP2185154A priority patent/JPH03135991A/ja
Application granted granted Critical
Publication of AR241751A1 publication Critical patent/AR241751A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A) EXTRAER DEL TEJIDO NERVIOSO HOMOGENEIZADO EN FORMA ESCALONADA ALCANOLES Y SOLVENTES ORGANICOS INERTES CLORADOS O AROMATICOS POCO MISCILES EN AGUA, LUEGO FILTRAR Y DILUIR EL FILTRADO CON AGUA YRECUPERAR LA FASE HIDROALCOHOLICA NO SALINA FORMADA, B) RETENER LOS GANGLIOSIDOS PRESENTES EN LA FASE CON UN MATERIAL DE INTERCAMBIO ANIONICO, LAVANDO LUEGO CON CETONAS. C) RECUPERAR LOS GANGLIOSIDOS RETENIDOS CON UNA MEZCLA SOLVENTE QUE INCLUYE AGUA-ALCANOLES Y SOLVENTES ORGANICOS POCO POLARES EN MEDIO ALCALINO, D) DESTILAR EL SOLVENTE Y EXTRAER EL RESIDUO CON UNA MEZCLA DE SOLVENTES QUE TIENE AGUA-ALCANOLES Y SOLVENTES ORGANICOS POCO POLARES Y PURIFICAR EL MATERIAL POR CROMATOGRAFIA DE ADSORCION EN COLUMNA DE SILICA GEL, E) ELUIR CON LA MEZCLA DE SOLVENTES MENCIONADA Y LUEGOCON MEZCLAS DE POLARIDAD CRECIENTE Y RECOGER LAS FRACCIONES QUE CONTIENEN GANGLIOSIDOS, F) EVAPORAR EL MEDIO SOLVENTE RECUPERANDO EL RESIDUO CON LOS GANGLIOSIDOS EXTRAIDOS.
AR89314371A 1989-07-12 1989-07-12 Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter. AR241751A1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AR89314371A AR241751A1 (es) 1989-07-12 1989-07-12 Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter.
EP19900307575 EP0409473A3 (en) 1989-07-12 1990-07-11 A process for obtaining the gangliosides from nervous tissue of mammalians and for the treatment of psychoorganic diseases with said material compositons
BR909003470A BR9003470A (pt) 1989-07-12 1990-07-12 Processo de obtencao de gangliosidas e mistura farmacologica das mesmas para tratamento de doencas psicossomaticas
JP2185154A JPH03135991A (ja) 1989-07-12 1990-07-12 哺乳類の神経組織からガングリオシド類を得る方法及び該物質組成物を用いた精神的器質性疾患の治療方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR89314371A AR241751A1 (es) 1989-07-12 1989-07-12 Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter.

Publications (1)

Publication Number Publication Date
AR241751A1 true AR241751A1 (es) 1992-12-30

Family

ID=3478704

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89314371A AR241751A1 (es) 1989-07-12 1989-07-12 Procedimiento para obtener mezclas de gangliosidos para el tratamiento de enfermedades psico-organicas y del caracter.

Country Status (4)

Country Link
EP (1) EP0409473A3 (es)
JP (1) JPH03135991A (es)
AR (1) AR241751A1 (es)
BR (1) BR9003470A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251991B (it) * 1991-11-08 1995-05-27 Fidia Spa Impiego di gangliosidi per la preparazione di composizioni farmaceutiche attive nella prevenzione di disfunzioni associate all'abuso di cocaina e psicostimolanti ad essa collegati
WO2010062197A1 (en) * 2008-11-25 2010-06-03 Eduard Nekrasov Dairy product and process
CN109705176A (zh) * 2019-01-23 2019-05-03 苏州纳微科技股份有限公司 一种猪神经节苷脂的分离纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1046051B (it) * 1975-08-13 1980-06-30 Fidia Spa Nuova applicazione terapeutica dei gangliosidi e procedimento per la loro estrazione
ES528692A0 (es) * 1984-01-04 1985-07-01 Bioiberica Procedimiento para la obtencion de un complejo glicoesfingolipidico
IT1223408B (it) * 1987-12-09 1990-09-19 Crinos Industria Farmaco Procedimento per la preparazione di monosialoganglioside

Also Published As

Publication number Publication date
EP0409473A3 (en) 1992-04-29
JPH03135991A (ja) 1991-06-10
BR9003470A (pt) 1991-08-27
EP0409473A2 (en) 1991-01-23

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