AR231987A1 - Procedimiento para preparar derivados farmaceuticos de pirrolo-2,1-c 1,4 tiazepin-1,5-diona y compuesto intermediario para uso exclusivo en el mismo - Google Patents
Procedimiento para preparar derivados farmaceuticos de pirrolo-2,1-c 1,4 tiazepin-1,5-diona y compuesto intermediario para uso exclusivo en el mismoInfo
- Publication number
- AR231987A1 AR231987A1 AR288889A AR28888982A AR231987A1 AR 231987 A1 AR231987 A1 AR 231987A1 AR 288889 A AR288889 A AR 288889A AR 28888982 A AR28888982 A AR 28888982A AR 231987 A1 AR231987 A1 AR 231987A1
- Authority
- AR
- Argentina
- Prior art keywords
- tiazepin
- pirrolo
- diona
- procedure
- intermediate compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8006414 | 1980-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR231987A1 true AR231987A1 (es) | 1985-04-30 |
Family
ID=10511671
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR284267A AR227663A1 (es) | 1980-02-26 | 1981-02-11 | Nuevo procedimiento para preparar derivados de prolina y compuestos analogos |
| AR288889A AR231987A1 (es) | 1980-02-26 | 1982-03-26 | Procedimiento para preparar derivados farmaceuticos de pirrolo-2,1-c 1,4 tiazepin-1,5-diona y compuesto intermediario para uso exclusivo en el mismo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR284267A AR227663A1 (es) | 1980-02-26 | 1981-02-11 | Nuevo procedimiento para preparar derivados de prolina y compuestos analogos |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US4349480A (es) |
| EP (1) | EP0035336B1 (es) |
| JP (2) | JPS56128755A (es) |
| AR (2) | AR227663A1 (es) |
| AU (2) | AU544337B2 (es) |
| CA (1) | CA1154782A (es) |
| DE (1) | DE3174292D1 (es) |
| GB (1) | GB2070005B (es) |
| IE (1) | IE50839B1 (es) |
| PH (3) | PH16751A (es) |
| ZA (1) | ZA81743B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
| NL180746C (nl) * | 1983-11-18 | 1987-04-16 | Matthijs Cornelis Evers | Werkwijze ter bereiding van captopril. |
| JPH0662671B2 (ja) * | 1986-01-17 | 1994-08-17 | 株式会社大塚製薬工場 | プロリン誘導体 |
| HU196368B (en) * | 1986-07-04 | 1988-11-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid |
| US4847384A (en) * | 1987-03-12 | 1989-07-11 | Sandoz Pharm. Corp. | Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor |
| US5237073A (en) * | 1988-08-26 | 1993-08-17 | Sepracor, Inc. | Derivatives and precursors of captopril and its analogues |
| US5166361A (en) * | 1988-09-13 | 1992-11-24 | Sepracor, Inc. | Methods for preparing captopril and its analogues |
| IL91581A (en) * | 1988-09-13 | 1993-07-08 | Sepracor Inc | Methods for preparing optically active captopril and its analogues |
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| DK0534363T3 (da) * | 1991-09-27 | 1997-09-22 | Merrell Pharma Inc | 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE. |
| CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| CA2130116C (en) * | 1992-02-14 | 1998-04-07 | Gary A. Flynn | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| ATE182892T1 (de) * | 1992-05-15 | 1999-08-15 | Merrell Pharma Inc | Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren |
| US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| CA2146238C (en) * | 1992-10-30 | 2001-03-13 | Gary A. Flynn | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
| CN1142831A (zh) * | 1994-02-14 | 1997-02-12 | 默里尔药物公司 | 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物 |
| ATE177098T1 (de) * | 1994-02-14 | 1999-03-15 | Merrell Pharma Inc | Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren |
| WO1995021840A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| PT750631E (pt) * | 1994-02-14 | 2000-07-31 | Merrell Pharma Inc | Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| JPH10503468A (ja) * | 1994-03-24 | 1998-03-31 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体 |
| DE69514912T2 (de) * | 1994-03-24 | 2000-10-05 | Merrell Pharmaceuticals Inc., Cincinnati | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| US7531217B2 (en) * | 2004-12-15 | 2009-05-12 | Iowa State University Research Foundation, Inc. | Methods for making high-temperature coatings having Pt metal modified γ-Ni +γ′-Ni3Al alloy compositions and a reactive element |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT986630B (it) * | 1972-04-20 | 1975-01-30 | Pierres Holding Sa | Procedimento per la lavorazione di precisione di pezzi mediante radiazioni laser e dispositivo per l esecuzione del procedi mento |
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4129566A (en) * | 1978-02-15 | 1978-12-12 | E. R. Squibb & Sons, Inc. | Derivatives of dehydrocyclicimino acids |
| US4127535A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel dipeptides, intermediates therefor, and compositions and methods employing said dipeptides |
| US4154935A (en) * | 1978-02-21 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Halogen substituted mercaptoacylamino acids |
| CA1109475A (en) * | 1978-07-27 | 1981-09-22 | Miguel A. Ondetti | Thiopropanoylamino acid derivatives |
| US4192945A (en) * | 1978-12-07 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Process for preparing proline and homoproline derivatives |
| EP0017390A3 (en) * | 1979-03-23 | 1981-06-24 | American Home Products Corporation | Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation |
| US4303583A (en) * | 1979-08-13 | 1981-12-01 | American Home Products Corporation | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones |
| US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
| GB2065643B (en) * | 1979-12-13 | 1983-08-24 | Kanegafuchi Chemical Ind | Optically active n-mercaptoalkanoylamino acids |
| HU184082B (en) * | 1979-12-29 | 1984-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
| IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
| US4454291A (en) * | 1981-07-20 | 1984-06-12 | American Home Products Corporation | N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives |
-
1981
- 1981-02-03 IE IE210/81A patent/IE50839B1/en not_active IP Right Cessation
- 1981-02-04 ZA ZA00810743A patent/ZA81743B/xx unknown
- 1981-02-05 AU AU66941/81A patent/AU544337B2/en not_active Expired
- 1981-02-10 CA CA000370546A patent/CA1154782A/en not_active Expired
- 1981-02-11 AR AR284267A patent/AR227663A1/es active
- 1981-02-12 GB GB8104412A patent/GB2070005B/en not_active Expired
- 1981-02-12 JP JP1957481A patent/JPS56128755A/ja active Pending
- 1981-02-12 DE DE8181300568T patent/DE3174292D1/de not_active Expired
- 1981-02-12 EP EP81300568A patent/EP0035336B1/en not_active Expired
- 1981-02-12 PH PH25215A patent/PH16751A/en unknown
- 1981-02-20 US US06/236,350 patent/US4349480A/en not_active Expired - Lifetime
-
1982
- 1982-02-19 PH PH26894A patent/PH17181A/en unknown
- 1982-02-19 PH PH26893A patent/PH17373A/en unknown
- 1982-03-26 AR AR288889A patent/AR231987A1/es active
- 1982-05-10 US US06/376,354 patent/US4578480A/en not_active Expired - Lifetime
- 1982-05-10 US US06/376,355 patent/US4506082A/en not_active Expired - Lifetime
- 1982-05-10 US US06/376,356 patent/US4391752A/en not_active Expired - Lifetime
-
1985
- 1985-02-25 AU AU39126/85A patent/AU566441B2/en not_active Expired - Fee Related
-
1987
- 1987-06-05 JP JP1987086778U patent/JPS62199283U/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3912685A (en) | 1985-07-11 |
| GB2070005A (en) | 1981-09-03 |
| PH17181A (en) | 1984-06-13 |
| PH16751A (en) | 1984-02-10 |
| ZA81743B (en) | 1982-09-29 |
| EP0035336A2 (en) | 1981-09-09 |
| DE3174292D1 (en) | 1986-05-15 |
| AU544337B2 (en) | 1985-05-23 |
| US4578480A (en) | 1986-03-25 |
| PH17373A (en) | 1984-08-06 |
| CA1154782A (en) | 1983-10-04 |
| AR227663A1 (es) | 1982-11-30 |
| AU6694181A (en) | 1981-09-03 |
| EP0035336A3 (en) | 1981-11-25 |
| JPS62199283U (es) | 1987-12-18 |
| IE50839B1 (en) | 1986-07-23 |
| AU566441B2 (en) | 1987-10-22 |
| GB2070005B (en) | 1984-12-19 |
| US4349480A (en) | 1982-09-14 |
| IE810210L (en) | 1981-08-26 |
| US4506082A (en) | 1985-03-19 |
| JPS56128755A (en) | 1981-10-08 |
| US4391752A (en) | 1983-07-05 |
| EP0035336B1 (en) | 1986-04-09 |
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