AR229703A1 - Procedimiento para la preparacion de nuevos 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina - Google Patents
Procedimiento para la preparacion de nuevos 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histaminaInfo
- Publication number
- AR229703A1 AR229703A1 AR290461A AR29046182A AR229703A1 AR 229703 A1 AR229703 A1 AR 229703A1 AR 290461 A AR290461 A AR 290461A AR 29046182 A AR29046182 A AR 29046182A AR 229703 A1 AR229703 A1 AR 229703A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroariltiazoles
- antisecreting
- guanidino
- agents
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19623180A | 1980-10-14 | 1980-10-14 | |
| US06/293,574 US4374843A (en) | 1980-10-14 | 1981-08-20 | 2-Guanidino-4-heteroarylthiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR229703A1 true AR229703A1 (es) | 1983-10-31 |
Family
ID=26891753
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR290462A AR228674A1 (es) | 1980-10-14 | 1982-08-27 | Procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina |
| AR290463A AR228675A1 (es) | 1980-10-14 | 1982-08-27 | Procedimiento para la preparacion de nuevos 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina |
| AR290461A AR229703A1 (es) | 1980-10-14 | 1982-08-27 | Procedimiento para la preparacion de nuevos 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR290462A AR228674A1 (es) | 1980-10-14 | 1982-08-27 | Procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina |
| AR290463A AR228675A1 (es) | 1980-10-14 | 1982-08-27 | Procedimiento para la preparacion de nuevos 2-guanidino-4-heteroariltiazoles activos como agentes antisecretores y como antagonistas h2 de la histamina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4374843A (el) |
| EP (1) | EP0050458B1 (el) |
| KR (1) | KR850001858B1 (el) |
| AR (3) | AR228674A1 (el) |
| AT (1) | ATE11048T1 (el) |
| AU (2) | AU530589B2 (el) |
| CA (1) | CA1156239A (el) |
| CS (1) | CS231182B2 (el) |
| DD (4) | DD202293A5 (el) |
| DE (1) | DE3168067D1 (el) |
| DK (1) | DK453181A (el) |
| ES (4) | ES8301978A1 (el) |
| FI (1) | FI75821C (el) |
| GR (1) | GR75098B (el) |
| HK (1) | HK52387A (el) |
| HU (2) | HU191895B (el) |
| IE (1) | IE51642B1 (el) |
| IL (1) | IL64035A (el) |
| KE (1) | KE3707A (el) |
| MY (1) | MY8700512A (el) |
| NO (1) | NO159654C (el) |
| NZ (1) | NZ198629A (el) |
| PH (3) | PH17562A (el) |
| PL (3) | PL133712B1 (el) |
| PT (1) | PT73817B (el) |
| SG (1) | SG23487G (el) |
| SU (1) | SU1153829A3 (el) |
| YU (4) | YU42434B (el) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4482723A (en) * | 1983-04-11 | 1984-11-13 | Pfizer Inc. | Process for preparation of 4-acetyl-2-substituted-imidazoles |
| US4435396A (en) * | 1982-05-10 | 1984-03-06 | Pfizer Inc. | Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor |
| AU542287B2 (en) * | 1982-06-17 | 1985-02-14 | Toyama Chemical Co. Ltd. | Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative, it:s salt and intermediates therefor |
| EP0156644A1 (en) * | 1984-04-02 | 1985-10-02 | Pfizer Inc. | Process and intermediates for 4-acetylimidazoles |
| US4560690A (en) * | 1984-04-30 | 1985-12-24 | Pfizer Inc. | 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents |
| US4591595A (en) * | 1984-10-11 | 1986-05-27 | Pfizer Inc. | 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis |
| US4632993A (en) * | 1984-10-11 | 1986-12-30 | Pfizer Inc. | Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide |
| US4567179A (en) * | 1984-10-11 | 1986-01-28 | Pfizer, Inc. | Antiinflammatory salts of piroxicam |
| WO1986003203A1 (en) * | 1984-11-22 | 1986-06-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylthiazole derivatives |
| US4814341A (en) * | 1986-08-26 | 1989-03-21 | Reiter Lawrence A | 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents |
| EP0259085B1 (en) * | 1986-08-29 | 1991-08-21 | Pfizer Inc. | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers |
| ATE106884T1 (de) * | 1986-10-29 | 1994-06-15 | Pfizer | Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat. |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| WO1992016526A1 (en) * | 1991-03-13 | 1992-10-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
| SI0928793T1 (en) * | 1998-01-02 | 2002-10-31 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| CN101287711A (zh) * | 2005-08-23 | 2008-10-15 | 宇部兴产株式会社 | 1-取代-5-酰基咪唑化合物的制备方法 |
| EP2832731A4 (en) | 2012-03-27 | 2015-08-19 | Shionogi & Co | AROMATIC HETEROCYCLIC CHAIN 5-CORE DERIVED DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1516777A (fr) * | 1966-08-02 | 1968-02-05 | Innothera Lab Sa | Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation |
| US3519637A (en) * | 1966-12-06 | 1970-07-07 | Hoffmann La Roche | 1-(4-thiazolylmethyl)nitroimidazole derivatives |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| US3950353A (en) * | 1971-03-09 | 1976-04-13 | Smith Kline & French Laboratories Limited | Pharmacologically active thiourea and urea compounds |
| HU168776B (el) * | 1973-11-09 | 1976-07-28 | ||
| DE2614189A1 (de) * | 1976-04-02 | 1977-10-20 | Hoechst Ag | Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung |
| ZA782129B (en) * | 1977-04-20 | 1979-03-28 | Ici Ltd | Hertocyclic derivatives |
| JPS54132566A (en) * | 1978-01-18 | 1979-10-15 | Ici Ltd | Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it |
| EP0014057B1 (en) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4220654A (en) * | 1979-06-04 | 1980-09-02 | Merck & Co., Inc. | Cyclic imidazole cyanoguanidines |
| AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
-
1981
- 1981-08-20 US US06/293,574 patent/US4374843A/en not_active Expired - Fee Related
- 1981-10-12 IE IE2384/81A patent/IE51642B1/en unknown
- 1981-10-12 EP EP81304724A patent/EP0050458B1/en not_active Expired
- 1981-10-12 AT AT81304724T patent/ATE11048T1/de not_active IP Right Cessation
- 1981-10-12 IL IL64035A patent/IL64035A/xx unknown
- 1981-10-12 DE DE8181304724T patent/DE3168067D1/de not_active Expired
- 1981-10-13 DK DK453181A patent/DK453181A/da not_active Application Discontinuation
- 1981-10-13 GR GR66268A patent/GR75098B/el unknown
- 1981-10-13 PH PH26341A patent/PH17562A/en unknown
- 1981-10-13 HU HU833918A patent/HU191895B/hu not_active IP Right Cessation
- 1981-10-13 ES ES506216A patent/ES8301978A1/es not_active Expired
- 1981-10-13 FI FI813177A patent/FI75821C/fi not_active IP Right Cessation
- 1981-10-13 CA CA000387744A patent/CA1156239A/en not_active Expired
- 1981-10-13 NO NO813442A patent/NO159654C/no unknown
- 1981-10-13 CS CS817500A patent/CS231182B2/cs unknown
- 1981-10-13 AU AU76287/81A patent/AU530589B2/en not_active Ceased
- 1981-10-13 HU HU812951A patent/HU186788B/hu not_active IP Right Cessation
- 1981-10-13 YU YU2464/81A patent/YU42434B/xx unknown
- 1981-10-13 NZ NZ198629A patent/NZ198629A/en unknown
- 1981-10-13 SU SU813344744A patent/SU1153829A3/ru active
- 1981-10-13 KR KR1019810003857A patent/KR850001858B1/ko active
- 1981-10-14 PL PL1981241643A patent/PL133712B1/pl unknown
- 1981-10-14 PL PL1981233430A patent/PL134491B1/pl unknown
- 1981-10-14 PT PT73817A patent/PT73817B/pt unknown
- 1981-10-14 PL PL1981241644A patent/PL135331B1/pl unknown
- 1981-10-14 DD DD81234080A patent/DD202293A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248820A patent/DD207718A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248822A patent/DD207913A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248821A patent/DD207719A5/de not_active IP Right Cessation
-
1982
- 1982-08-20 ES ES515158A patent/ES515158A0/es active Granted
- 1982-08-20 ES ES515159A patent/ES515159A0/es active Granted
- 1982-08-20 ES ES515157A patent/ES515157A0/es active Granted
- 1982-08-27 AR AR290462A patent/AR228674A1/es active
- 1982-08-27 AR AR290463A patent/AR228675A1/es active
- 1982-08-27 AR AR290461A patent/AR229703A1/es active
-
1983
- 1983-04-06 PH PH28740A patent/PH18467A/en unknown
- 1983-04-06 PH PH28741A patent/PH17856A/en unknown
- 1983-05-12 YU YU1053/83A patent/YU42078B/xx unknown
- 1983-05-12 YU YU1052/83A patent/YU42077B/xx unknown
- 1983-05-12 YU YU1051/83A patent/YU42076B/xx unknown
-
1984
- 1984-08-17 AU AU32062/84A patent/AU548992B2/en not_active Ceased
-
1987
- 1987-03-09 SG SG234/87A patent/SG23487G/en unknown
- 1987-03-20 KE KE3707A patent/KE3707A/xx unknown
- 1987-07-09 HK HK523/87A patent/HK52387A/xx unknown
- 1987-12-30 MY MY512/87A patent/MY8700512A/xx unknown
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