AR226157A1 - Procedimiento para preparar esteroide-21-halogeno-17-(alquil carbonatos) - Google Patents

Procedimiento para preparar esteroide-21-halogeno-17-(alquil carbonatos)

Info

Publication number
AR226157A1
AR226157A1 AR276277A AR27627779A AR226157A1 AR 226157 A1 AR226157 A1 AR 226157A1 AR 276277 A AR276277 A AR 276277A AR 27627779 A AR27627779 A AR 27627779A AR 226157 A1 AR226157 A1 AR 226157A1
Authority
AR
Argentina
Prior art keywords
rent
carbonates
halogen
procedure
preparing steroid
Prior art date
Application number
AR276277A
Other languages
English (en)
Spanish (es)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR226157A1 publication Critical patent/AR226157A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AR276277A 1978-04-25 1979-04-23 Procedimiento para preparar esteroide-21-halogeno-17-(alquil carbonatos) AR226157A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782817988 DE2817988A1 (de) 1978-04-25 1978-04-25 Corticoid 17-alkylcarbonate und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
AR226157A1 true AR226157A1 (es) 1982-06-15

Family

ID=6037909

Family Applications (1)

Application Number Title Priority Date Filing Date
AR276277A AR226157A1 (es) 1978-04-25 1979-04-23 Procedimiento para preparar esteroide-21-halogeno-17-(alquil carbonatos)

Country Status (19)

Country Link
US (1) US4377575A (fr)
EP (1) EP0004975B1 (fr)
JP (1) JPS54144357A (fr)
AR (1) AR226157A1 (fr)
AT (1) AT372094B (fr)
AU (1) AU529172B2 (fr)
CA (1) CA1130276A (fr)
DE (2) DE2817988A1 (fr)
DK (1) DK157880C (fr)
ES (2) ES479709A1 (fr)
FI (1) FI791307A (fr)
GR (1) GR72886B (fr)
HU (1) HU180788B (fr)
IE (1) IE48328B1 (fr)
IL (1) IL57114A (fr)
NO (1) NO791365L (fr)
NZ (1) NZ190256A (fr)
PT (1) PT69544A (fr)
ZA (1) ZA791941B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
JPS5835199A (ja) * 1981-08-26 1983-03-01 Mitsubishi Chem Ind Ltd モノヨ−ドステロイドおよびその製造法
JPS58103400A (ja) * 1981-12-11 1983-06-20 Ota Seiyaku Kk ６α−メチルプレドニゾロン誘導体
JPS6056997A (ja) * 1983-09-07 1985-04-02 Mitsubishi Chem Ind Ltd 新規な６−酸素化コルチコイド／７α−カ−ボネ−ト誘導体およびその製法
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE4328819A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
AU7576001A (en) * 2000-08-05 2002-02-18 Glaxo Group Ltd 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
EP1383786B1 (fr) * 2001-04-30 2008-10-15 Glaxo Group Limited Derives anti-inflammatoires d'androstane 17.beta.-carbothioate ester avec un groupe cyclique en position 17.alpha
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040138192A1 (en) * 2003-01-13 2004-07-15 Chemagis Ltd. Crystalline forms of halobetasol propionate
US7208485B2 (en) * 2003-01-13 2007-04-24 Chemagis Ltd. Crystalline forms of halobetasol propionate
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
NZ584160A (en) * 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
KR20100102121A (ko) * 2007-12-20 2010-09-20 아스트라제네카 아베 글루코코르티코스테로이드 수용체 효능제로서 작용하는 스테로이드 유도체
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
GB1281689A (en) * 1968-10-14 1972-07-12 Glaxo Lab Ltd Steroid 21-phosphates
US3558675A (en) * 1969-06-30 1971-01-26 Merck & Co Inc Steroid carbonates and process
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
US3832366A (en) * 1973-07-30 1974-08-27 Squibb & Sons Inc Process for preparing 21-chloro-17-acyloxy-20-ketosteroids
YU54476A (en) * 1975-03-31 1982-05-31 Taisho Pharmaceutical Co Ltd Process for obtaining 17-ester 21-halo-pregnane
US4021459A (en) * 1975-08-14 1977-05-03 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS6252759B2 (fr) 1987-11-06
PT69544A (de) 1979-05-01
US4377575A (en) 1983-03-22
EP0004975A3 (en) 1979-11-14
IE48328B1 (en) 1984-12-12
DE2962122D1 (en) 1982-03-25
IL57114A (en) 1983-11-30
EP0004975A2 (fr) 1979-10-31
CA1130276A (fr) 1982-08-24
EP0004975B1 (fr) 1982-02-17
ATA307479A (de) 1983-01-15
DE2817988A1 (de) 1979-11-08
IL57114A0 (en) 1979-07-25
ES488120A1 (es) 1980-09-16
ZA791941B (en) 1980-04-30
JPS54144357A (en) 1979-11-10
NZ190256A (en) 1981-03-16
DK157880B (da) 1990-02-26
DK157880C (da) 1990-07-30
FI791307A (fi) 1979-10-26
NO791365L (no) 1979-10-26
ES479709A1 (es) 1980-08-16
HU180788B (en) 1983-04-29
GR72886B (fr) 1984-01-02
IE790831L (en) 1979-10-25
DK168579A (da) 1979-10-26
AT372094B (de) 1983-08-25
AU529172B2 (en) 1983-05-26

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