AR192602A1 - Preparacion de aza-8 purinonas-6 sustituidas en 2 - Google Patents

Preparacion de aza-8 purinonas-6 sustituidas en 2

Info

Publication number
AR192602A1
AR192602A1 AR239632A AR23963271A AR192602A1 AR 192602 A1 AR192602 A1 AR 192602A1 AR 239632 A AR239632 A AR 239632A AR 23963271 A AR23963271 A AR 23963271A AR 192602 A1 AR192602 A1 AR 192602A1
Authority
AR
Argentina
Prior art keywords
purinones
aza
substituted
preparation
Prior art date
Application number
AR239632A
Other languages
English (en)
Spanish (es)
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Application granted granted Critical
Publication of AR192602A1 publication Critical patent/AR192602A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AR239632A 1970-12-15 1971-12-15 Preparacion de aza-8 purinonas-6 sustituidas en 2 AR192602A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5955670 1970-12-15
GB5955270 1970-12-15
GB4975671A GB1338235A (en) 1970-12-15 1971-10-26 Azapurinones
GB5345771 1971-11-17

Publications (1)

Publication Number Publication Date
AR192602A1 true AR192602A1 (es) 1973-02-28

Family

ID=27449009

Family Applications (4)

Application Number Title Priority Date Filing Date
AR239632A AR192602A1 (es) 1970-12-15 1971-12-15 Preparacion de aza-8 purinonas-6 sustituidas en 2
AR245508A AR199467A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de aza-8 purinonas-6 sustituidas en 2
AR245510A AR192689A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de sales aceptables farmaceuticamente de las aza-8 purinonas-6 sustituidas
AR245509A AR199468A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de aza-8 purinonas-6 sustituidas en 2

Family Applications After (3)

Application Number Title Priority Date Filing Date
AR245508A AR199467A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de aza-8 purinonas-6 sustituidas en 2
AR245510A AR192689A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de sales aceptables farmaceuticamente de las aza-8 purinonas-6 sustituidas
AR245509A AR199468A1 (es) 1970-12-15 1972-12-06 Procedimiento de preparacion de aza-8 purinonas-6 sustituidas en 2

Country Status (25)

Country Link
US (1) US3987160A (fr)
JP (1) JPS5310599B1 (fr)
AR (4) AR192602A1 (fr)
AT (4) AT315839B (fr)
AU (1) AU458277B2 (fr)
BE (1) BE776683A (fr)
BG (3) BG20806A3 (fr)
CH (5) CH556860A (fr)
DD (1) DD95007A5 (fr)
DE (1) DE2162096A1 (fr)
DK (1) DK141249B (fr)
FI (1) FI53457C (fr)
FR (1) FR2118078B1 (fr)
GB (1) GB1338235A (fr)
HK (1) HK42177A (fr)
HU (1) HU165079B (fr)
IE (1) IE35897B1 (fr)
IL (1) IL38364A (fr)
IS (1) IS1099B6 (fr)
LU (1) LU64457A1 (fr)
NL (1) NL174943C (fr)
NO (1) NO134257C (fr)
OA (1) OA03930A (fr)
SE (1) SE393381B (fr)
ZM (1) ZM18971A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
FR2406638A1 (fr) * 1977-10-21 1979-05-18 May & Baker Ltd Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant
EP0007727B1 (fr) * 1978-07-24 1983-11-30 Beecham Group Plc Benzopyranotriazoles, préparation de ces composés et composition pharmaceutique les contenant
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
CA1303037C (fr) * 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Derives de purinone utilises comme bronchodilatateurs,vasodilatateurs et agents anti-allergiques
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
DE3873812D1 (de) * 1987-04-07 1992-09-24 Ciba Geigy Ag 3h-1,2,3-triazolo(4,5-d)pyrimidine.
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
DE4211239C2 (de) * 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
US5734053A (en) * 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
BR9812785A (pt) 1997-11-12 2000-10-10 Bayer Ag "imidazotriazinonas 2-fenil-substituìdas como inibidores de fosfodiesterase"
DE19838705A1 (de) * 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
CA3089569C (fr) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (fr) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828346C (fr) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Procede de preparation d'agonistes du guanylate cyclase c
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN110381951A (zh) 2016-12-14 2019-10-25 瑞必治公司 用于治疗肺性高血压和其他肺病症的方法及组合物
TW202043234A (zh) 2019-01-24 2020-12-01 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
EP3972599A1 (fr) 2019-05-21 2022-03-30 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
TW202219047A (zh) * 2020-07-23 2022-05-16 美商普羅米修斯生物科學股份有限公司 靶向gpr35之治療劑

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407204A (en) * 1944-07-22 1946-09-03 American Cyanamid Co Triazolo (d) pyrimidines and methods of preparing the same
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars

Also Published As

Publication number Publication date
AT319235B (de) 1974-12-10
AT315839B (de) 1974-06-10
DE2162096C2 (fr) 1988-02-11
FI53457B (fr) 1978-01-31
HU165079B (fr) 1974-06-28
CH552610A (fr) 1974-08-15
FR2118078B1 (fr) 1975-08-01
NO134257B (fr) 1976-05-31
SE393381B (sv) 1977-05-09
GB1338235A (en) 1973-11-21
DD95007A5 (fr) 1973-01-12
IE35897B1 (en) 1976-06-23
CH546779A (fr) 1974-03-15
CH550814A (fr) 1974-06-28
NL174943B (nl) 1984-04-02
NO134257C (fr) 1976-09-08
DE2162096A1 (de) 1972-07-06
IS2047A7 (is) 1972-06-16
BG20806A3 (fr) 1975-12-20
FI53457C (fi) 1978-05-10
AR192689A1 (es) 1973-02-28
IS1099B6 (is) 1982-11-18
IL38364A0 (en) 1972-02-29
DK141249C (fr) 1980-08-04
AU3686771A (en) 1973-06-21
FR2118078A1 (fr) 1972-07-28
LU64457A1 (fr) 1972-08-23
HK42177A (en) 1977-08-19
AR199468A1 (es) 1974-09-09
NL174943C (nl) 1984-09-03
AR199467A1 (es) 1974-09-09
JPS5310599B1 (fr) 1978-04-14
CH555351A (fr) 1974-10-31
ZM18971A1 (en) 1972-08-21
US3987160A (en) 1976-10-19
CH556860A (de) 1974-12-13
AT315838B (de) 1974-06-10
IE35897L (en) 1972-06-15
NL7117142A (fr) 1972-06-19
IL38364A (en) 1975-08-31
DK141249B (da) 1980-02-11
AT317211B (de) 1974-08-26
AU458277B2 (en) 1975-02-20
OA03930A (fr) 1975-08-14
BG20805A3 (fr) 1975-12-20
BE776683A (fr) 1972-06-14
BG20807A3 (fr) 1975-12-20

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