IL38364A - 8-azapurin-6-one derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

8-azapurin-6-one derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL38364A
IL38364A IL38364A IL3836471A IL38364A IL 38364 A IL38364 A IL 38364A IL 38364 A IL38364 A IL 38364A IL 3836471 A IL3836471 A IL 3836471A IL 38364 A IL38364 A IL 38364A
Authority
IL
Israel
Prior art keywords
azapurin
derivatives
processes
preparation
same
Prior art date
Application number
IL38364A
Other languages
English (en)
Other versions
IL38364A0 (en
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of IL38364A0 publication Critical patent/IL38364A0/xx
Priority to IL45007A priority Critical patent/IL45007A/xx
Publication of IL38364A publication Critical patent/IL38364A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL38364A 1970-12-15 1971-12-14 8-azapurin-6-one derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same IL38364A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL45007A IL45007A (en) 1971-12-14 1974-06-11 8-azapurin-6-one derivatives, process for the preparation thereof and pharmaceutical compositions containing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5955670 1970-12-15
GB5955270 1970-12-15
GB4975671A GB1338235A (en) 1970-12-15 1971-10-26 Azapurinones
GB5345771 1971-11-17

Publications (2)

Publication Number Publication Date
IL38364A0 IL38364A0 (en) 1972-02-29
IL38364A true IL38364A (en) 1975-08-31

Family

ID=27449009

Family Applications (1)

Application Number Title Priority Date Filing Date
IL38364A IL38364A (en) 1970-12-15 1971-12-14 8-azapurin-6-one derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (25)

Country Link
US (1) US3987160A (fr)
JP (1) JPS5310599B1 (fr)
AR (4) AR192602A1 (fr)
AT (4) AT315838B (fr)
AU (1) AU458277B2 (fr)
BE (1) BE776683A (fr)
BG (3) BG20805A3 (fr)
CH (5) CH546779A (fr)
DD (1) DD95007A5 (fr)
DE (1) DE2162096A1 (fr)
DK (1) DK141249B (fr)
FI (1) FI53457C (fr)
FR (1) FR2118078B1 (fr)
GB (1) GB1338235A (fr)
HK (1) HK42177A (fr)
HU (1) HU165079B (fr)
IE (1) IE35897B1 (fr)
IL (1) IL38364A (fr)
IS (1) IS1099B6 (fr)
LU (1) LU64457A1 (fr)
NL (1) NL174943C (fr)
NO (1) NO134257C (fr)
OA (1) OA03930A (fr)
SE (1) SE393381B (fr)
ZM (1) ZM18971A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
FR2406638A1 (fr) * 1977-10-21 1979-05-18 May & Baker Ltd Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant
EP0007727B1 (fr) * 1978-07-24 1983-11-30 Beecham Group Plc Benzopyranotriazoles, préparation de ces composés et composition pharmaceutique les contenant
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
CA1303037C (fr) * 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Derives de purinone utilises comme bronchodilatateurs,vasodilatateurs et agents anti-allergiques
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
EP0288431B1 (fr) * 1987-04-07 1992-08-19 Ciba-Geigy Ag 3H-1,2,3-triazolo[4,5-d]pyrimidines
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
DE4211239C2 (de) * 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
US5734053A (en) * 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
CN1123573C (zh) 1997-11-12 2003-10-08 拜尔公司 用作磷酸二酯酶抑制剂的2－苯基取代的咪唑并三嗪酮
DE19838705A1 (de) * 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
EP3030252B1 (fr) 2013-08-09 2018-11-07 Ardelyx, Inc. Composés et procédés d'inhibition du transport de phosphate
RU2019121646A (ru) 2016-12-14 2021-01-15 Респира Терапьютикс, Инк. Способы и композиции для лечения легочной гипертензии и других заболеваний легких
TW202043234A (zh) 2019-01-24 2020-12-01 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
EP3972599A1 (fr) 2019-05-21 2022-03-30 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
EP4185379A4 (fr) * 2020-07-23 2023-11-22 Prometheus Biosciences, Inc. Agents thérapeutiques ciblant gpr35

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407204A (en) * 1944-07-22 1946-09-03 American Cyanamid Co Triazolo (d) pyrimidines and methods of preparing the same
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars

Also Published As

Publication number Publication date
HU165079B (fr) 1974-06-28
AR199468A1 (es) 1974-09-09
HK42177A (en) 1977-08-19
IE35897B1 (en) 1976-06-23
NO134257C (fr) 1976-09-08
AR192689A1 (es) 1973-02-28
BG20806A3 (fr) 1975-12-20
AT319235B (de) 1974-12-10
BG20807A3 (fr) 1975-12-20
DK141249B (da) 1980-02-11
NO134257B (fr) 1976-05-31
CH550814A (fr) 1974-06-28
IS1099B6 (is) 1982-11-18
AU3686771A (en) 1973-06-21
IE35897L (en) 1972-06-15
IS2047A7 (is) 1972-06-16
AT317211B (de) 1974-08-26
DE2162096C2 (fr) 1988-02-11
FR2118078A1 (fr) 1972-07-28
CH546779A (fr) 1974-03-15
NL7117142A (fr) 1972-06-19
BE776683A (fr) 1972-06-14
US3987160A (en) 1976-10-19
DE2162096A1 (de) 1972-07-06
CH552610A (fr) 1974-08-15
FR2118078B1 (fr) 1975-08-01
GB1338235A (en) 1973-11-21
FI53457C (fi) 1978-05-10
ZM18971A1 (en) 1972-08-21
AT315838B (de) 1974-06-10
DD95007A5 (fr) 1973-01-12
OA03930A (fr) 1975-08-14
BG20805A3 (fr) 1975-12-20
AR192602A1 (es) 1973-02-28
AU458277B2 (en) 1975-02-20
NL174943B (nl) 1984-04-02
NL174943C (nl) 1984-09-03
LU64457A1 (fr) 1972-08-23
AT315839B (de) 1974-06-10
CH556860A (de) 1974-12-13
DK141249C (fr) 1980-08-04
FI53457B (fr) 1978-01-31
CH555351A (fr) 1974-10-31
JPS5310599B1 (fr) 1978-04-14
SE393381B (sv) 1977-05-09
AR199467A1 (es) 1974-09-09
IL38364A0 (en) 1972-02-29

Similar Documents

Publication Publication Date Title
IL38364A (en) 8-azapurin-6-one derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL37984A0 (en) 2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL36398A0 (en) 3,4-dihydroisoquinoline derivatives,processes for their preparation and pharmaceutical compositions containing the same
PH9682A (en) 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives and pharmaceutical composition containing same
IL36211A0 (en) N(6)-aralkyl-adenosine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
IL37598A0 (en) Bis-chromonyloxy compounds,their preparation and pharmaceutical compositions containing them
ZA715545B (en) Thiopyrimidine derivatives,processes for their preparation and compositions containing them
IL35847A0 (en) New evomonoside derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
IL39851A (en) 1,2,3,4,4a,10b-hexahydro-phenanthridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL36345A (en) Benzhydryl-piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL36286A0 (en) Erythromycylamine compounds,process for the preparation thereof and pharmaceutical compositions containing the same
IL36285A0 (en) Erythromycylamine compounds,processes for preparation thereof and pharmaceutical compositions containing them
IL37146A0 (en) Indenopyrrole derivatives,their preparation and pharmaceutical compositions containing them
IL36559A (en) N-substituted-4-hydroxy-4-benzoyl-3-phenyl-piperidine derivatives,their preparation and pharmaceutical compositions containing them
IL41350A0 (en) Indole-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL40807A (en) Heterocyclic-substituted nebularin derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
IL35870A0 (en) New neriifolin derivatives,processes for their preparation and pharmaceutical compositions containing the same
IL36160A (en) 7-azido-5-phenyl-dihydro-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL36397A (en) N-vinyl-quinolones,processes for the preparation thereof and pharmaceutical compositions containing the same
IL35070A0 (en) Dibenzazepine derivatives,processes for their preparation and pharmaceutical compositions containing the same
IL40194A0 (en) New phenothiazine derivatives,processes for their preparation and pharmaceutical compositions containing the same
IL37609A0 (en) Novel benzodiazepine derivatives,processes for their preparation and pharmaceutical compositions containing the same
IL42179A0 (en) Cyclopentenoquinolone derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL37231A0 (en) Bornanamine derivatives,their preparation and pharmaceutical compositions containing them
IL37621A (en) Benzocycloheptathiophene derivatives,their preparation and pharmaceutical compositions containing them