AR127562A1 - ANTICUERPOS CONTRA EL FACTOR DE NECROSIS TUMORAL a HUMANO - Google Patents
ANTICUERPOS CONTRA EL FACTOR DE NECROSIS TUMORAL a HUMANOInfo
- Publication number
- AR127562A1 AR127562A1 ARP220103012A ARP220103012A AR127562A1 AR 127562 A1 AR127562 A1 AR 127562A1 AR P220103012 A ARP220103012 A AR P220103012A AR P220103012 A ARP220103012 A AR P220103012A AR 127562 A1 AR127562 A1 AR 127562A1
- Authority
- AR
- Argentina
- Prior art keywords
- human
- nucleic acid
- antibodies against
- necrosis factor
- vector
- Prior art date
Links
- 230000017074 necrotic cell death Effects 0.000 title 1
- 230000001173 tumoral effect Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 108700012920 TNF Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente descripción se refiere a anticuerpos que se unen específicamente a formas solubles y de membrana del TNFa humano, composiciones que comprenden dichos anticuerpos contra el TNFa y métodos para usar dichos anticuerpos contra el TNFa y composiciones. Reivindicación 20: Un ácido nucleico que comprende una secuencia que codifica la SEQ ID Nº 9, 10, 18, 19, 25, 28, 35 o 36. Reivindicación 21: Un vector que comprende el ácido nucleico de la reivindicación 20. Reivindicación 23: Una composición que comprende un primer vector que comprende una secuencia de ácido nucleico que codifica la SEQ ID Nº 9, 18, 25 o 35, y un segundo vector que comprende una secuencia de ácido nucleico que codifica la SEQ ID Nº 10, 19, 28 o 36. Reivindicación 25: La célula de la reivindicación 24, en donde la célula es una célula de mamífero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163278245P | 2021-11-11 | 2021-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR127562A1 true AR127562A1 (es) | 2024-02-07 |
Family
ID=84799771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220103012A AR127562A1 (es) | 2021-11-11 | 2022-11-02 | ANTICUERPOS CONTRA EL FACTOR DE NECROSIS TUMORAL a HUMANO |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230192837A1 (es) |
AR (1) | AR127562A1 (es) |
AU (1) | AU2022386645A1 (es) |
CA (1) | CA3237268A1 (es) |
TW (1) | TW202334220A (es) |
WO (1) | WO2023086871A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240082414A1 (en) * | 2022-05-13 | 2024-03-14 | Eli Lilly And Company | Human tumor necrosis factor alpha antibody glucocorticoid conjugates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7073487B2 (ja) | 2017-06-16 | 2022-05-23 | イーライ リリー アンド カンパニー | 操作された抗体化合物およびこれらの抱合体 |
-
2022
- 2022-11-02 AR ARP220103012A patent/AR127562A1/es unknown
- 2022-11-03 TW TW111141987A patent/TW202334220A/zh unknown
- 2022-11-10 CA CA3237268A patent/CA3237268A1/en active Pending
- 2022-11-10 US US18/054,284 patent/US20230192837A1/en active Pending
- 2022-11-10 WO PCT/US2022/079616 patent/WO2023086871A2/en active Application Filing
- 2022-11-10 AU AU2022386645A patent/AU2022386645A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230192837A1 (en) | 2023-06-22 |
WO2023086871A3 (en) | 2023-06-22 |
TW202334220A (zh) | 2023-09-01 |
CA3237268A1 (en) | 2023-05-19 |
WO2023086871A2 (en) | 2023-05-19 |
AU2022386645A1 (en) | 2024-05-16 |
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