AR126820A1 - Anticuerpos - Google Patents
AnticuerposInfo
- Publication number
- AR126820A1 AR126820A1 ARP220102228A ARP220102228A AR126820A1 AR 126820 A1 AR126820 A1 AR 126820A1 AR P220102228 A ARP220102228 A AR P220102228A AR P220102228 A ARP220102228 A AR P220102228A AR 126820 A1 AR126820 A1 AR 126820A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- seq
- cdr
- hla
- host cell
- Prior art date
Links
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 abstract 6
- 108010024164 HLA-G Antigens Proteins 0.000 abstract 6
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 239000013604 expression vector Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 102000006471 Fucosyltransferases Human genes 0.000 abstract 1
- 108010019236 Fucosyltransferases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013599 cloning vector Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a anticuerpos dirigidos contra HLA-G y formulaciones que los comprenden. La invención se refiere, además, al uso de los anticuerpos HLA-G y formulaciones en tratamientos, en especial en el tratamiento de tumores sólidos. Reivindicación 1: Un anticuerpo que se une específicamente a HLA-G, en donde el anticuerpo comprende: a. una región variable de cadena ligera que comprende: i. una CDR-L1 que comprende el SEQ ID Nº 1; ii. una CDR-L2 que comprende el SEQ ID Nº 2 y iii. una CDR-L3 que comprende el SEQ ID Nº 3, y b. una región variable de cadena pesada que comprende: i. una CDR-H1 que comprende el SEQ ID Nº 4; ii. una CDR-H2 que comprende el SEQ ID Nº 5 y iii. una CDR-H3 que comprende el SEQ ID Nº 6. Reivindicación 22: Un anticuerpo que compite de forma cruzada con el anticuerpo de la reivindicación 1 para unirse a HLA-G o se une a un epítopo de HLA-G que comprende V194, F195, Y197, E198, Q224, Q226, D227, V248, V249, P250 e Y257 de HLA-G (SEQ ID Nº 107). Reivindicación 23: Un polinucleótido aislado que codifica el anticuerpo de acuerdo con una cualquiera de las reivindicaciones 1 a 22. Reivindicación 26: Un vector de clonación o de expresión que comprende uno o más polinucleótidos de acuerdo con una cualquiera de las reivindicaciones 23 a 25. Reivindicación 27: Una célula hospedante que comprende uno o más polinucleótidos de acuerdo con una cualquiera de las reivindicaciones 23 a 25 o uno o más vectores de expresión de acuerdo con la reivindicación 26. Reivindicación 28: Una célula hospedante que comprende uno o más polinucleótidos de acuerdo con una cualquiera de las reivindicaciones 23 a 25 o uno o más vectores de expresión de acuerdo con la reivindicación 26, en donde la célula hospedante fue modificada genéticamente para disminuir o suprimir la función de la a1,6 fucosiltransferasa. Reivindicación 29: Un proceso para la producción de un anticuerpo de acuerdo con una cualquiera de las reivindicaciones 1 a 22, que comprende cultivar la célula hospedante de acuerdo con la reivindicación 27 o 28 en condiciones adecuadas para producir el anticuerpo y aislar el anticuerpo. Reivindicación 30: Un proceso para la producción de una composición farmacéutica que comprende el anticuerpo de acuerdo con una cualquiera de las reivindicaciones 1 a 22, que comprende las etapas del proceso como se define en la reivindicación 29 y que comprende, además, formular el anticuerpo en una composición farmacéutica. Reivindicación 31: Una composición farmacéutica que comprende el anticuerpo de acuerdo con una cualquiera de las reivindicaciones 1 a 22 y uno o más vehículos, excipientes o diluyentes farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2111905.2A GB202111905D0 (en) | 2021-08-19 | 2021-08-19 | Antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
AR126820A1 true AR126820A1 (es) | 2023-11-15 |
Family
ID=77913991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102228A AR126820A1 (es) | 2021-08-19 | 2022-08-18 | Anticuerpos |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP4388007A1 (es) |
KR (1) | KR20240046577A (es) |
CN (1) | CN118369341A (es) |
AR (1) | AR126820A1 (es) |
AU (1) | AU2022330347A1 (es) |
BR (1) | BR112024001989A2 (es) |
CA (1) | CA3227160A1 (es) |
CO (1) | CO2024001711A2 (es) |
GB (1) | GB202111905D0 (es) |
IL (1) | IL310245A (es) |
TW (1) | TW202315889A (es) |
WO (1) | WO2023021187A1 (es) |
Family Cites Families (73)
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GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
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GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
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ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
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DK2334705T3 (en) | 2008-09-26 | 2017-03-27 | Ucb Biopharma Sprl | BIOLOGICAL PRODUCTS |
EP2475682B1 (en) | 2009-09-10 | 2018-01-31 | UCB Biopharma SPRL | Multivalent antibodies |
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EP2730588A1 (en) * | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
GB201223276D0 (en) | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
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JP7034950B2 (ja) * | 2016-06-03 | 2022-03-14 | アンヴェクティ | 抗hla-g特異的抗体 |
TW201829463A (zh) * | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
EP3434688A1 (en) * | 2017-07-24 | 2019-01-30 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Hla-g transcripts and isoforms and their uses |
AR114789A1 (es) | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
EA202190609A1 (ru) | 2018-09-27 | 2021-08-17 | Тизона Терапьютикс | Антитела против hla-g, композиции, содержащие антитела против hla-g, и способы применения антител против hla-g |
-
2021
- 2021-08-19 GB GBGB2111905.2A patent/GB202111905D0/en not_active Ceased
-
2022
- 2022-08-18 AR ARP220102228A patent/AR126820A1/es unknown
- 2022-08-19 IL IL310245A patent/IL310245A/en unknown
- 2022-08-19 TW TW111131251A patent/TW202315889A/zh unknown
- 2022-08-19 CA CA3227160A patent/CA3227160A1/en active Pending
- 2022-08-19 EP EP22769886.7A patent/EP4388007A1/en active Pending
- 2022-08-19 WO PCT/EP2022/073195 patent/WO2023021187A1/en active Application Filing
- 2022-08-19 AU AU2022330347A patent/AU2022330347A1/en active Pending
- 2022-08-19 CN CN202280063210.8A patent/CN118369341A/zh active Pending
- 2022-08-19 BR BR112024001989A patent/BR112024001989A2/pt unknown
- 2022-08-19 KR KR1020247009075A patent/KR20240046577A/ko unknown
-
2024
- 2024-02-19 CO CONC2024/0001711A patent/CO2024001711A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA3227160A1 (en) | 2023-02-23 |
CO2024001711A2 (es) | 2024-03-07 |
WO2023021187A1 (en) | 2023-02-23 |
BR112024001989A2 (pt) | 2024-04-30 |
KR20240046577A (ko) | 2024-04-09 |
GB202111905D0 (en) | 2021-10-06 |
IL310245A (en) | 2024-03-01 |
AU2022330347A1 (en) | 2024-02-01 |
CN118369341A (zh) | 2024-07-19 |
TW202315889A (zh) | 2023-04-16 |
EP4388007A1 (en) | 2024-06-26 |
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