AR123684A1 - Compuesto de tetrahidrobenzofurodiazepinona y uso farmacéutico del mismo - Google Patents
Compuesto de tetrahidrobenzofurodiazepinona y uso farmacéutico del mismoInfo
- Publication number
- AR123684A1 AR123684A1 ARP210102742A ARP210102742A AR123684A1 AR 123684 A1 AR123684 A1 AR 123684A1 AR P210102742 A ARP210102742 A AR P210102742A AR P210102742 A ARP210102742 A AR P210102742A AR 123684 A1 AR123684 A1 AR 123684A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- atom
- hydroxy
- independently
- cycloalkyl
- Prior art date
Links
- -1 TETRAHYDROBENZOFURODIAZEPINONE COMPOUND Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000001924 cycloalkanes Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula [1], o una sal aceptable para uso farmacéutico del mismo, caracterizado porque Cy¹ es (1) cicloalquilo C₃₋₇, (2) heterocicloalquilo de 4 a 7 miembros que contiene uno o dos heteroátomos seleccionados de manera independiente del grupo que consiste en átomos de oxígeno y azufre (el átomo de azufre puede estar oxidado), como un átomo que constituye el anillo además de los átomos de carbono, (3) cicloalquilo C₅₋₈ puenteado, (4) heterocicloalquilo puenteado de 7 a 9 miembros que contiene un átomo de oxígeno como un átomo que constituye el anillo además de los átomos de carbono, (5) espirocicloalquilo C₇₋₁₁, o (6) espiroheterocicloalquilo de 7 a 11 miembros que contiene de uno a tres átomos de oxígeno como un átomo que constituye el anillo además de los átomos de carbono; R¹ en el número de m son cada uno de manera independiente (1) halógeno, (2) hidroxi, (3) alquilo C₁₋₆ en el que el alquilo está sustituido de manera opcional con (a) hidroxi, (b) alcoxi C₁₋₄, (c) ciano, (d) OCOR¹¹ en el que R¹¹ es fenilo, o (e) SO₂R¹² en el que R¹² es alquilo C₁₋₄, (4) haloalquilo C₁₋₄ en el que el haloalquilo está sustituido de manera opcional con hidroxi, (5) alcoxi C₁₋₄ en el que el alcoxi está sustituido de manera opcional con 1 a 3 halógenos, (6) COR¹³ en el que R¹³ es (a) hidroxi, o (b) NR¹⁴R¹⁵ en el que R¹⁴ y R¹⁵ son cada uno de manera independiente hidrógeno o alquilo C₁₋₄, (7) ciano, (8) SO₂R¹⁶ en el que R¹⁶ es alquilo C₁₋₄, (9) cicloalquilo C₃₋₄ en el que el cicloalquilo está sustituido de manera opcional con hidroxi, o (10) triazolilo, o dos R¹ unidos al mismo átomo de carbono se toman juntos para formar oxo; R² en el número de n son cada uno de manera independiente (1) halógeno, o (2) alcoxi C₁₋₄, o dos R² unidos al mismo átomo de carbono se toman juntos para formar cicloalcano C₃₋₄ con el átomo de carbono al que están unidos; R³ y R⁴ son cada uno de manera independiente (1) hidrógeno, o (2) alquilo C₁₋₄, o R³ y R⁴ se toman juntos para formar cicloalcano C₃₋₄ con el átomo de carbono al que están unidos; R⁵ es hidrógeno o alquilo C₁₋₄; R⁶ es haloalquilo C₁₋₄; R⁷ es hidrógeno o halógeno; L es alquileno C₁₋₄ lineal; m es 0, 1, 2, 3 ó 4; y n es 0, 1, 2 ó 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020168596 | 2020-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123684A1 true AR123684A1 (es) | 2023-01-04 |
Family
ID=81125276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102742A AR123684A1 (es) | 2020-10-05 | 2021-10-04 | Compuesto de tetrahidrobenzofurodiazepinona y uso farmacéutico del mismo |
Country Status (17)
Country | Link |
---|---|
US (2) | US11643417B2 (es) |
EP (1) | EP4227308A1 (es) |
JP (1) | JP2022061021A (es) |
KR (1) | KR20230083305A (es) |
CN (1) | CN116437927A (es) |
AR (1) | AR123684A1 (es) |
AU (1) | AU2021357608A1 (es) |
BR (1) | BR112023005024A2 (es) |
CA (1) | CA3196024A1 (es) |
CL (1) | CL2023000977A1 (es) |
CO (1) | CO2023005262A2 (es) |
IL (1) | IL301866A (es) |
MX (1) | MX2023003932A (es) |
PE (1) | PE20240065A1 (es) |
TW (1) | TW202229287A (es) |
WO (1) | WO2022075240A1 (es) |
ZA (1) | ZA202304169B (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002014324A2 (en) * | 2000-08-16 | 2002-02-21 | Warner-Lambert Company | Diazepinones as antiviral agents |
US20040116410A1 (en) | 2001-08-07 | 2004-06-17 | Hidetsura Cho | Diazepinones as antiviral agents |
TW200930375A (en) | 2007-12-21 | 2009-07-16 | Exelixis Inc | Benzofuropyrimidinones |
-
2021
- 2021-10-04 TW TW110136886A patent/TW202229287A/zh unknown
- 2021-10-04 AR ARP210102742A patent/AR123684A1/es unknown
- 2021-10-04 MX MX2023003932A patent/MX2023003932A/es unknown
- 2021-10-04 JP JP2021163209A patent/JP2022061021A/ja active Pending
- 2021-10-04 WO PCT/JP2021/036553 patent/WO2022075240A1/ja active Application Filing
- 2021-10-04 KR KR1020237014912A patent/KR20230083305A/ko unknown
- 2021-10-04 EP EP21877539.3A patent/EP4227308A1/en active Pending
- 2021-10-04 PE PE2023001375A patent/PE20240065A1/es unknown
- 2021-10-04 CN CN202180067988.1A patent/CN116437927A/zh active Pending
- 2021-10-04 CA CA3196024A patent/CA3196024A1/en active Pending
- 2021-10-04 IL IL301866A patent/IL301866A/en unknown
- 2021-10-04 BR BR112023005024A patent/BR112023005024A2/pt unknown
- 2021-10-04 US US17/493,528 patent/US11643417B2/en active Active
- 2021-10-04 AU AU2021357608A patent/AU2021357608A1/en active Pending
-
2023
- 2023-03-21 US US18/124,389 patent/US20240116943A1/en active Pending
- 2023-04-04 CL CL2023000977A patent/CL2023000977A1/es unknown
- 2023-04-05 ZA ZA2023/04169A patent/ZA202304169B/en unknown
- 2023-04-25 CO CONC2023/0005262A patent/CO2023005262A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2022075240A1 (ja) | 2022-04-14 |
ZA202304169B (en) | 2023-12-20 |
CO2023005262A2 (es) | 2023-05-19 |
CA3196024A1 (en) | 2022-04-14 |
US11643417B2 (en) | 2023-05-09 |
CL2023000977A1 (es) | 2023-09-29 |
US20220162220A1 (en) | 2022-05-26 |
BR112023005024A2 (pt) | 2023-04-18 |
IL301866A (en) | 2023-06-01 |
PE20240065A1 (es) | 2024-01-11 |
TW202229287A (zh) | 2022-08-01 |
KR20230083305A (ko) | 2023-06-09 |
US20240116943A1 (en) | 2024-04-11 |
JP2022061021A (ja) | 2022-04-15 |
AU2021357608A1 (en) | 2023-06-08 |
CN116437927A (zh) | 2023-07-14 |
EP4227308A1 (en) | 2023-08-16 |
MX2023003932A (es) | 2023-04-26 |
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