AR121669A1 - Compuesto de piridazina sustituida - Google Patents
Compuesto de piridazina sustituidaInfo
- Publication number
- AR121669A1 AR121669A1 ARP210100758A ARP210100758A AR121669A1 AR 121669 A1 AR121669 A1 AR 121669A1 AR P210100758 A ARP210100758 A AR P210100758A AR P210100758 A ARP210100758 A AR P210100758A AR 121669 A1 AR121669 A1 AR 121669A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogenated
- cycloalkyl
- formula
- alkylene
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos derivados de piridazina sustituida como inhibidores de la activación de inflamasoma NLRP3, una composición farmacéutica que comprende a uno de éstos compuestos y el uso de los mismos para el tratamiento de una enfermedad inflamatoria o neurodegenerativa. Reivindicación 1: Un compuesto de la fórmula (1) o una sal de este, caracterizado por que Ar es un grupo representado por la siguiente fórmula (2) ó (3), donde * representa un sitio de enlace al anillo piridazina de la fórmula (1); L es alquileno C₁₋₆ o cicloalquileno C₃₋₈; R¹ es H, alquilo C₁₋₆, cicloalquilo C₃₋₈, arilo, heteroarilo opcionalmente sustituido con 1 a 4 alquilos C₁₋₆, ciano, -OR⁷ o -N(alquilo C₁₋₆)₂; R² es H, alquilo C₁₋₆, cicloalquilo C₃₋₈, arilo, heteroarilo opcionalmente sustituido con 1 a 4 alquilos C₁₋₆, ciano, -OR⁷, -N(alquilo C₁₋₆)₂, -C(=O)O-alquilo C₁₋₆ o -C(=O)NR⁸R⁹; R³ es OH, -NHC(=O)R¹⁰ o -OC(=O)-alquilo C₁₋₆; R⁴ es halógeno, O-alquilo C₁₋₆ o alquilo C₁₋₆ halogenado; R⁵ es H, cicloalquilo C₃₋₈ o alquilo C₁₋₆ halogenado; R⁶ es H, halógeno, -O-alquilo C₁₋₆ o alquilo C₁₋₆ halogenado; R⁷ es -alquileno C₁₋₆-O-alquileno C₁₋₆-arilo o alquilo C₁₋₆ halogenado; R⁸ y R⁹ son iguales o diferentes, y cada uno es H o alquilo C₁₋₆; o R⁸ y R⁹, juntos con un átomo de nitrógeno al cual R⁸ y R⁹ están enlazados, forman morfolina, piperazina o tiomorfolina y la morfolina, piperazina o tiomorfolina está opcionalmente sustituida con alquilo C₁₋₆; y R¹⁰ es alquilo C₁₋₆, alquilo C₁₋₆ halogenado o cicloalquilo C₃₋₈, siempre que, cuando Ar es un grupo representado por la fórmula (2) con R⁵ que es H, R⁴ es alquilo C₁₋₆ halogenado, y uno de R¹ y R² es un grupo diferente que H.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020057623 | 2020-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR121669A1 true AR121669A1 (es) | 2022-06-29 |
Family
ID=77890352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210100758A AR121669A1 (es) | 2020-03-27 | 2021-03-26 | Compuesto de piridazina sustituida |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230107277A1 (es) |
EP (1) | EP4129986A4 (es) |
JP (1) | JPWO2021193897A1 (es) |
CN (1) | CN115279739A (es) |
AR (1) | AR121669A1 (es) |
TW (1) | TW202204323A (es) |
WO (1) | WO2021193897A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
CN116867769A (zh) * | 2021-02-08 | 2023-10-10 | 南京明德新药研发有限公司 | 取代的哒嗪苯酚类衍生物 |
CA3218212A1 (en) | 2021-04-28 | 2022-11-03 | Astellas Pharma Inc. | Substituted triazine compound |
AU2022304254A1 (en) | 2021-07-02 | 2024-02-08 | Astrazeneca Ab | Nlrp3 inflammasome inhibitors |
TW202319055A (zh) | 2021-07-21 | 2023-05-16 | 日商安斯泰來製藥股份有限公司 | 縮環噠嗪(pyridazine)化合物 |
WO2023066377A1 (zh) | 2021-10-22 | 2023-04-27 | 索智生物科技(浙江)有限公司 | 一种含氮化合物、其制备方法及应用 |
WO2023088987A1 (en) * | 2021-11-19 | 2023-05-25 | F. Hoffmann-La Roche Ag | Pyridazine derivatives as inhibitors of nlrp3 |
WO2023186020A1 (en) * | 2022-03-31 | 2023-10-05 | Hangzhou Highlightll Pharmaceutical Co., Ltd | Nlrp3 inflammasome inhibitors |
WO2023220408A1 (en) * | 2022-05-13 | 2023-11-16 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
WO2024006559A1 (en) * | 2022-07-01 | 2024-01-04 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
US20240034735A1 (en) | 2022-07-14 | 2024-02-01 | Ac Immune Sa | Novel compounds |
WO2024012551A1 (zh) * | 2022-07-14 | 2024-01-18 | 南京明德新药研发有限公司 | 氘取代的哒嗪苯并噻吩化合物及其应用 |
WO2024023266A1 (en) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | Novel compounds |
CN116789674B (zh) * | 2022-08-24 | 2024-05-24 | 杭州高光制药有限公司 | Nlrp3炎性小体抑制剂 |
US20240124451A1 (en) | 2022-09-23 | 2024-04-18 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
WO2024090469A1 (ja) * | 2022-10-26 | 2024-05-02 | アステラス製薬株式会社 | 縮環ピリダジン誘導体 |
CN117986258A (zh) * | 2022-11-04 | 2024-05-07 | 药捷安康(南京)科技股份有限公司 | Nlrp3炎症小体抑制剂及其应用 |
WO2024160690A1 (en) | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | 2-(pyridazin-3-yl)-5-(trifluoromethyl)phenols as nlrp3 inhibitors |
WO2024160692A1 (en) | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | Imidazo[1,2-d][1,2,4]triazines as nlrp3 inhibitors |
WO2024160694A1 (en) | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | [1,2,4]TRIAZOLO[4,3-a]PYRIDINES AND [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS NLRP3 INHIBITORS |
WO2024160691A1 (en) | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | PYRROLO[1,2-d][1,2,4]TRIAZINES AND PYRAZOLO[1,5-d] [1,2,4]TRIAZINES AS NLRP3 INHIBITORS |
WO2024160693A1 (en) | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | Pyridin-2(1h)-ones and pyrimidin-4(3h)-ones as nlrp3 inhibitors |
WO2024169858A1 (zh) * | 2023-02-17 | 2024-08-22 | 成都赜灵生物医药科技有限公司 | 六元氮杂环类化合物及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2473522A1 (fr) * | 1980-01-16 | 1981-07-17 | Synthelabo | Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent |
FR2663326B2 (fr) * | 1989-11-17 | 1992-10-16 | Sanofi Sa | Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant. |
US6602872B1 (en) * | 1999-12-13 | 2003-08-05 | Merck & Co., Inc. | Substituted pyridazines having cytokine inhibitory activity |
US6664256B1 (en) * | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
WO2007127474A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
WO2017184604A1 (en) | 2016-04-18 | 2017-10-26 | Ifm Therapeutics, Inc | Compounds and compositions for treating conditions associated with nlrp activity |
EP3272739A1 (en) | 2016-07-20 | 2018-01-24 | NodThera Limited | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
ES2906280T3 (es) * | 2017-07-07 | 2022-04-18 | Inflazome Ltd | Nuevos compuestos de sulfonamida carboxamida |
AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
-
2021
- 2021-03-26 WO PCT/JP2021/012773 patent/WO2021193897A1/ja unknown
- 2021-03-26 AR ARP210100758A patent/AR121669A1/es unknown
- 2021-03-26 EP EP21775125.4A patent/EP4129986A4/en active Pending
- 2021-03-26 TW TW110110988A patent/TW202204323A/zh unknown
- 2021-03-26 JP JP2022510720A patent/JPWO2021193897A1/ja active Pending
- 2021-03-26 CN CN202180020248.2A patent/CN115279739A/zh active Pending
- 2021-03-26 US US17/909,171 patent/US20230107277A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230107277A1 (en) | 2023-04-06 |
EP4129986A4 (en) | 2024-05-22 |
EP4129986A1 (en) | 2023-02-08 |
TW202204323A (zh) | 2022-02-01 |
WO2021193897A1 (ja) | 2021-09-30 |
JPWO2021193897A1 (es) | 2021-09-30 |
CN115279739A (zh) | 2022-11-01 |
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