AR120685A1 - Proceso e intermediarios para la producción de la fórmula (1) - Google Patents

Proceso e intermediarios para la producción de la fórmula (1)

Info

Publication number
AR120685A1
AR120685A1 ARP200103398A ARP200103398A AR120685A1 AR 120685 A1 AR120685 A1 AR 120685A1 AR P200103398 A ARP200103398 A AR P200103398A AR P200103398 A ARP200103398 A AR P200103398A AR 120685 A1 AR120685 A1 AR 120685A1
Authority
AR
Argentina
Prior art keywords
formula
production
intermediaries
methyl
compound
Prior art date
Application number
ARP200103398A
Other languages
English (en)
Inventor
Jerome Dubiez
Andrew Turner
Richard Chubb
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR120685A1 publication Critical patent/AR120685A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un proceso para la producción del compuesto de fórmula (1) que comprende el paso de (i) la reacción del compuesto de fórmula (2), (6R)-7-[(3,4-difluorofenil)metil]-6-(metoximetil)-2-(5-metil-2-metilsulfonil-pirimidin-4-il)-5,6-dihidroimidazo[1,2-a]pirazin-8-ona y 2-metilpirazol-3-amino de fórmula (3).
ARP200103398A 2019-12-05 2020-12-04 Proceso e intermediarios para la producción de la fórmula (1) AR120685A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962943851P 2019-12-05 2019-12-05

Publications (1)

Publication Number Publication Date
AR120685A1 true AR120685A1 (es) 2022-03-09

Family

ID=73748050

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200103398A AR120685A1 (es) 2019-12-05 2020-12-04 Proceso e intermediarios para la producción de la fórmula (1)

Country Status (13)

Country Link
US (1) US20230046093A1 (es)
EP (1) EP4069687B1 (es)
JP (1) JP2023505771A (es)
KR (1) KR20220112764A (es)
CN (1) CN114746410A (es)
AR (1) AR120685A1 (es)
AU (1) AU2020397222B2 (es)
CA (1) CA3157504A1 (es)
CO (1) CO2022008102A2 (es)
IL (1) IL293382A (es)
MX (1) MX2022006856A (es)
TW (1) TW202134242A (es)
WO (1) WO2021110893A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122020014933B8 (pt) * 2014-04-09 2022-12-13 Genentech Inc Compostos, composições farmacêuticas, benzenossulfonatos, forma a de ácido p-toluenossulfônico, forma b de ácido p-toluenssulfônico, forma i do ácido naftalenodissulfônico e forma ii do ácido naftalendissulfônico
UY36629A (es) * 2015-04-17 2016-11-30 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
BR112018008397B1 (pt) * 2015-11-09 2023-12-12 Astrazeneca Ab Composto, sal farmacêuticamente aceitável e formas cristalinas
ES2789756T3 (es) * 2015-12-23 2020-10-26 Merck Sharp & Dohme Moduladores alostéricos de 6,7-dihidro-5H-pirrolo[3,4-b]piridin-5-ona del receptor de acetilcolina muscarínico M4

Also Published As

Publication number Publication date
EP4069687B1 (en) 2024-01-31
TW202134242A (zh) 2021-09-16
AU2020397222B2 (en) 2023-07-06
MX2022006856A (es) 2022-07-11
AU2020397222A1 (en) 2022-04-28
JP2023505771A (ja) 2023-02-13
CA3157504A1 (en) 2021-06-10
WO2021110893A1 (en) 2021-06-10
KR20220112764A (ko) 2022-08-11
CO2022008102A2 (es) 2022-07-08
EP4069687A1 (en) 2022-10-12
IL293382A (en) 2022-07-01
CN114746410A (zh) 2022-07-12
US20230046093A1 (en) 2023-02-16

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