AR119010A1 - Compuestos, composiciones y métodos de uso - Google Patents
Compuestos, composiciones y métodos de usoInfo
- Publication number
- AR119010A1 AR119010A1 ARP200101482A ARP200101482A AR119010A1 AR 119010 A1 AR119010 A1 AR 119010A1 AR P200101482 A ARP200101482 A AR P200101482A AR P200101482 A ARP200101482 A AR P200101482A AR 119010 A1 AR119010 A1 AR 119010A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- independently selected
- haloalkoxy
- haloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000020038 Cholesterol 24-Hydroxylase Human genes 0.000 abstract 1
- 108091022871 Cholesterol 24-Hydroxylase Proteins 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962852565P | 2019-05-24 | 2019-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR119010A1 true AR119010A1 (es) | 2021-11-17 |
Family
ID=71078654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200101482A AR119010A1 (es) | 2019-05-24 | 2020-05-26 | Compuestos, composiciones y métodos de uso |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220332699A1 (https=) |
| EP (1) | EP3976186A1 (https=) |
| JP (2) | JP7687964B2 (https=) |
| AR (1) | AR119010A1 (https=) |
| MA (1) | MA56032A (https=) |
| TW (2) | TW202523658A (https=) |
| WO (1) | WO2020243027A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2848212C (en) | 2011-09-08 | 2022-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| EP2806877B2 (en) | 2012-01-23 | 2025-01-29 | Sage Therapeutics, Inc. | Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin |
| CA2882708A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| KR102396328B1 (ko) | 2013-04-17 | 2022-05-10 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| WO2016082789A1 (en) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| SMT202200300T1 (it) | 2016-04-01 | 2022-09-14 | Sage Therapeutics Inc | Ossisteroli e relativi metodi d'uso |
| EP3504189A1 (en) | 2016-08-23 | 2019-07-03 | Sage Therapeutics, Inc. | A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid |
| MA51046A (fr) | 2017-12-08 | 2021-03-17 | Sage Therapeutics Inc | Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc |
| IL309208A (en) | 2021-06-11 | 2024-02-01 | Sage Therapeutics Inc | Neuroactive steroid for the treatment of alzheimer's disease |
| CN113501787A (zh) * | 2021-08-20 | 2021-10-15 | 黑龙江省科学院石油化学研究院 | 一种合成6-三氟甲基-3-甲基吲唑的方法 |
| US20240189312A1 (en) * | 2022-12-02 | 2024-06-13 | Morehouse School Of Medicine | Composition for treating acute brain injury or neurodegenerative disease, method of making, and use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854204A (en) | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| JP2001500852A (ja) | 1996-08-27 | 2001-01-23 | プレーシス ファーマスーティカルズ インコーポレイテッド | Ｄ―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| US20100152160A1 (en) * | 2008-12-12 | 2010-06-17 | Khamrai Uttam | Novel benzodioxane and benzoxazine derivatives useful as cc chemokine receptor ligands |
| US8642621B2 (en) * | 2009-09-16 | 2014-02-04 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use |
| AU2011247116B2 (en) * | 2010-04-29 | 2015-12-03 | The University Of Edinburgh | 3, 3 -disubstituted- ( 8 - aza - bicyclo [3.2.1] oct- 8 - yl) -[5- (1H - pyrazol - 4 -yl) -thiophen-3 -yl] methanones as inhibitors of 11 (beta) -HSD1 |
| AP2014007606A0 (en) * | 2011-10-07 | 2014-05-31 | Takeda Pharmaceutical | 1-Arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases |
| HUE039922T2 (hu) | 2012-12-11 | 2019-02-28 | Takeda Pharmaceuticals Co | Heterociklusos vegyületek |
| EP2982666B1 (en) * | 2013-04-04 | 2019-08-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| MX2022003845A (es) * | 2019-09-30 | 2022-06-22 | Actinogen Medical Ltd | Tratamientos cognitivos medicinales. |
-
2020
- 2020-05-22 TW TW113132645A patent/TW202523658A/zh unknown
- 2020-05-22 TW TW109117233A patent/TWI855081B/zh active
- 2020-05-24 MA MA056032A patent/MA56032A/fr unknown
- 2020-05-24 WO PCT/US2020/034434 patent/WO2020243027A1/en not_active Ceased
- 2020-05-24 JP JP2021569396A patent/JP7687964B2/ja active Active
- 2020-05-24 US US17/613,870 patent/US20220332699A1/en active Pending
- 2020-05-24 EP EP20732078.9A patent/EP3976186A1/en active Pending
- 2020-05-26 AR ARP200101482A patent/AR119010A1/es unknown
-
2025
- 2025-03-10 JP JP2025037274A patent/JP2025090698A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI855081B (zh) | 2024-09-11 |
| US20220332699A1 (en) | 2022-10-20 |
| MA56032A (fr) | 2022-04-06 |
| WO2020243027A1 (en) | 2020-12-03 |
| TW202110824A (zh) | 2021-03-16 |
| JP2022533436A (ja) | 2022-07-22 |
| TW202523658A (zh) | 2025-06-16 |
| JP7687964B2 (ja) | 2025-06-03 |
| EP3976186A1 (en) | 2022-04-06 |
| JP2025090698A (ja) | 2025-06-17 |
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