AR111265A1 - Combinaciones farmacéuticas, kit, célula huésped, uso - Google Patents
Combinaciones farmacéuticas, kit, célula huésped, usoInfo
- Publication number
- AR111265A1 AR111265A1 ARP180100556A ARP180100556A AR111265A1 AR 111265 A1 AR111265 A1 AR 111265A1 AR P180100556 A ARP180100556 A AR P180100556A AR P180100556 A ARP180100556 A AR P180100556A AR 111265 A1 AR111265 A1 AR 111265A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- seq
- binding portion
- pharmaceutical combination
- antigen binding
- Prior art date
Links
- 239000000427 antigen Substances 0.000 abstract 11
- 102000036639 antigens Human genes 0.000 abstract 11
- 108091007433 antigens Proteins 0.000 abstract 11
- 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 abstract 6
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 abstract 6
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 abstract 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 abstract 2
- 238000007792 addition Methods 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 241001529936 Murinae Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960004641 rituximab Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se relaciona en general con los campos de la inmunología y la biología molecular. En la presente se proporcionan combinaciones farmacéuticas que comprenden (A) anticuerpos, o porciones de unión al antígeno de los mismos, dirigidos contra LY75, y (B) una segunda entidad anti-cáncer; ácidos nucleicos que codifican combinaciones de anticuerpos; métodos para preparar combinaciones de anticuerpos; y métodos para el tratamiento de enfermedades, tales como cánceres mediados por la expresión o la actividad de LY75. Reivindicación 1: Una combinación farmacéutica que comprende: (A) un anticuerpo anti LY75, o una porción de unión al antígeno del mismo, el cual compite por la unión a LY75 con un anticuerpo que comprende una región variable de cadena pesada que comprende la secuencia de aminoácidos expuesta en SEC ID Nº 1, y una región variable de cadena ligera que comprende la secuencia de aminoácidos expuesta en SEC ID Nº 2; o un anticuerpo anti LY75, o una porción de unión al antígeno del mismo, comprendiendo dicho anticuerpo: a) una región variable de cadena pesada que comprende: i) una primera vhCDR que comprende SEC ID Nº 5; ii) una segunda vhCDR que comprende SEC ID Nº 6; y iii) una tercera vhCDR que comprende SEC ID Nº 7; y b) una región variable de cadena ligera que comprende: i) una primera vlCDR que comprende SEC ID Nº 8; ii) una segunda vlCDR que comprende SEC ID Nº 9; y iii) una tercera vlCDR que comprende SEC ID Nº 10; opcionalmente donde una cualquiera o más de las SEC ID Nº antes expuestas comprenden independientemente uno, dos, tres, cuatro o cinco sustituciones, adiciones o deleciones de aminoácidos; y (B) un anticuerpo anti CD20 o una porción de unión al antígeno del mismo, comprendiendo dicho anticuerpo: a) una región variable de cadena pesada que comprende: i) una primera vhCDR que comprende SEC ID Nº 40; ii) una segunda vhCDR que comprende SEC ID Nº 41; y iii) una tercera vhCDR que comprende SEC ID Nº 42; y b) una región variable de cadena ligera que comprende: i) una primera vlCDR que comprende SEC ID Nº 43; ii) una segunda vlCDR que comprende SEC ID Nº 44; y iii) una tercera vlCDR que comprende SEC ID Nº 45; opcionalmente donde una cualquiera o más de las SEC ID Nº antes expuestas comprenden independientemente uno, dos, tres, cuatro o cinco sustituciones, adiciones o deleciones de aminoácidos; donde la combinación farmacéutica está en la forma de una preparación combinada para uso simultáneo, separado o secuencial, preferentemente para el tratamiento de cáncer. Reivindicación 7: La combinación farmacéutica de acuerdo con cualquiera de las reivindicaciones 1 a 6, donde el anticuerpo anti LY75 o una porción de unión al antígeno del mismo además comprende un resto unido covalentemente. Reivindicación 8: La combinación farmacéutica de acuerdo con la reivindicación 7, donde dicho resto es un fármaco. Reivindicación 9: La combinación farmacéutica de acuerdo con la reivindicación 8, donde dicho fármaco es un maitansinoide o un derivado de este. Reivindicación 10: La combinación farmacéutica de acuerdo con la reivindicación 9, donde dicho fármaco es DM4 o DM1. Reivindicación 13: La combinación farmacéutica de acuerdo con cualquiera de las reivindicaciones 1 ó 3 a 12, donde el anticuerpo anti CD20 es un anticuerpo quimérico murino / humano, un anticuerpo humanizado o un anticuerpo humano. Reivindicación 14: La combinación farmacéutica de acuerdo con cualquiera de las reivindicaciones 1 ó 3 a 13, donde el anticuerpo anti CD20 es Rituximab. Reivindicación 19: Una célula huésped que comprende vectores de expresión que comprenden ácidos nucleicos que codifican: (i) la cadena pesada del anticuerpo anti LY75 o una porción de unión al antígeno del mismo de la reivindicación 1; (ii) la cadena ligera del anticuerpo anti LY75 o una porción de unión al antígeno del mismo de la reivindicación 1; (iii) la cadena pesada del anticuerpo anti CD20 o una porción de unión al antígeno del mismo de la reivindicación 1; y (iv) la cadena ligera del anticuerpo anti CD20 o una porción de unión al antígeno del mismo de la reivindicación 1. Reivindicación 22: El método de la reivindicación 20 ó 21, donde el anticuerpo anti LY75 o la porción de unión al antígeno del mismo comprende un fármaco conjugado unido covalentemente. Reivindicación 25: Una combinación farmacéutica de acuerdo con cualquiera de las reivindicaciones 1 a 15, para usar en el tratamiento de cáncer, donde los componentes (A) y (B) se administran simultánea, separada o secuencialmente a un paciente para el tratamiento del cáncer. Reivindicación 26: La combinación farmacéutica para usar de acuerdo con la reivindicación 25, donde el anticuerpo anti LY75 o una porción de unión al antígeno del mismo es internalizado por una célula que expresa LY75.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1703876.1A GB201703876D0 (en) | 2017-03-10 | 2017-03-10 | Pharmaceutical combinations |
Publications (1)
Publication Number | Publication Date |
---|---|
AR111265A1 true AR111265A1 (es) | 2019-06-26 |
Family
ID=58605343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180100556A AR111265A1 (es) | 2017-03-10 | 2018-03-09 | Combinaciones farmacéuticas, kit, célula huésped, uso |
Country Status (23)
Country | Link |
---|---|
US (2) | US11365258B2 (es) |
EP (2) | EP4257614A3 (es) |
JP (1) | JP7220153B2 (es) |
KR (1) | KR102538294B1 (es) |
CN (2) | CN116808198A (es) |
AR (1) | AR111265A1 (es) |
AU (1) | AU2018232886A1 (es) |
CA (1) | CA3054904A1 (es) |
CO (1) | CO2019009815A2 (es) |
CR (1) | CR20190422A (es) |
EA (1) | EA201991845A1 (es) |
GB (1) | GB201703876D0 (es) |
IL (1) | IL269140A (es) |
MA (1) | MA49977A (es) |
MX (2) | MX2019010673A (es) |
MY (1) | MY197735A (es) |
PH (1) | PH12019502000A1 (es) |
SG (1) | SG11201907207UA (es) |
TW (1) | TWI789379B (es) |
UA (1) | UA128081C2 (es) |
UY (1) | UY37630A (es) |
WO (1) | WO2018162727A1 (es) |
ZA (2) | ZA201905021B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
EP4346882A1 (en) * | 2021-05-26 | 2024-04-10 | Oxford BioTherapeutics Ltd | Pharmaceutical combination comprising an anti-cd205 antibody and an immune checkpoint inhibitor |
US20230113866A1 (en) * | 2021-09-13 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Methods Of Treating Clonal Hematopoiesis Of Indeterminate Potential (CHIP) With Lymphocyte Antigen 75 (LY75), Cluster Of Differentiation 164 (CD164), Or Poly(ADP-Ribose) Polymerase 1 (PARP1) Inhibitors |
CN114252592B (zh) * | 2021-11-22 | 2024-05-31 | 广州万孚生物技术股份有限公司 | 一种可溶性fms样酪氨酸激酶-1检测试剂盒及其制备方法与应用 |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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