AR110384A1 - Proceso para la fabricación de derivados de diazepina - Google Patents

Proceso para la fabricación de derivados de diazepina

Info

Publication number
AR110384A1
AR110384A1 ARP170103540A ARP170103540A AR110384A1 AR 110384 A1 AR110384 A1 AR 110384A1 AR P170103540 A ARP170103540 A AR P170103540A AR P170103540 A ARP170103540 A AR P170103540A AR 110384 A1 AR110384 A1 AR 110384A1
Authority
AR
Argentina
Prior art keywords
manufacture
compound
formula
derivatives
diazepin
Prior art date
Application number
ARP170103540A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR110384A1 publication Critical patent/AR110384A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Abstract

La solicitud se refiere a un proceso para la fabricación de derivados de diazepina. Reivindicación 1: Un proceso para la fabricación de un compuesto de fórmula (1), que comprende las siguientes etapas: (a) la reacción de un compuesto de fórmula (2), que tiene una relación enantiomérica de al menos 70:30 con un ácido para llegar al compuesto de fórmula (1); y (b) la cristalización del compuesto de fórmula (1) obtenido en la etapa (a) a partir de acetato de isopropilo; en donde R¹ es alquilo.
ARP170103540A 2016-12-16 2017-12-15 Proceso para la fabricación de derivados de diazepina AR110384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2016110279 2016-12-16

Publications (1)

Publication Number Publication Date
AR110384A1 true AR110384A1 (es) 2019-03-27

Family

ID=60857055

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103540A AR110384A1 (es) 2016-12-16 2017-12-15 Proceso para la fabricación de derivados de diazepina

Country Status (13)

Country Link
US (1) US20190284202A1 (es)
EP (1) EP3555059A1 (es)
JP (1) JP2020502148A (es)
KR (1) KR20190092429A (es)
CN (1) CN110088095A (es)
AR (1) AR110384A1 (es)
AU (1) AU2017376583A1 (es)
BR (1) BR112019008435A2 (es)
CA (1) CA3041949A1 (es)
IL (1) IL267305A (es)
MX (1) MX2019006956A (es)
TW (1) TW201827420A (es)
WO (1) WO2018109053A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020533365A (ja) * 2017-09-14 2020-11-19 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 医薬の製造に有用な新規化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661284A1 (en) 1992-09-18 1995-07-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
WO1998011111A1 (fr) 1996-09-13 1998-03-19 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thienotriazolodiazepine et leurs utilisations a des fins medicinales
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
GB0722340D0 (en) * 2007-11-14 2007-12-27 Univ Leiden Sphingosine-1-phosphate (S1P) receptor compounds
BR122014024883A2 (pt) * 2010-05-14 2019-08-20 Dana-Farber Cancer Institute, Inc. Compostos no tratamento de neoplasia
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
CN103180318B (zh) * 2010-05-14 2017-05-10 达那-法伯癌症研究所 雄性避孕组合物以及使用方法
JP5715241B2 (ja) * 2010-05-14 2015-05-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法
CN106456653A (zh) * 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
ES2751642T3 (es) * 2014-04-09 2020-04-01 Kainos Medicine Inc Compuestos inhibidores de bromodominios y composición farmacéutica que los comprende para prevenir o tratar un cáncer

Also Published As

Publication number Publication date
MX2019006956A (es) 2019-08-01
KR20190092429A (ko) 2019-08-07
IL267305A (en) 2019-08-29
CN110088095A (zh) 2019-08-02
WO2018109053A1 (en) 2018-06-21
EP3555059A1 (en) 2019-10-23
AU2017376583A1 (en) 2019-05-16
CA3041949A1 (en) 2018-06-21
US20190284202A1 (en) 2019-09-19
JP2020502148A (ja) 2020-01-23
TW201827420A (zh) 2018-08-01
BR112019008435A2 (pt) 2019-07-09

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