AR110068A2 - 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas - Google Patents

2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas

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Publication number
AR110068A2
AR110068A2 ARP170103158A ARP170103158A AR110068A2 AR 110068 A2 AR110068 A2 AR 110068A2 AR P170103158 A ARP170103158 A AR P170103158A AR P170103158 A ARP170103158 A AR P170103158A AR 110068 A2 AR110068 A2 AR 110068A2
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
amino
phenyl
group
Prior art date
Application number
ARP170103158A
Other languages
English (en)
Inventor
Zhenhai Gao
Kristin Brinner
John Tulinsky
Dan Gu
Baoqing Gong
Yasheen Zhou
Maureen Mkenna
John Dolan
Barry H Levine
Brandon M Doughan
William Antonios-Mcrea
Christopher Mbride
Cynthia M Shafer
Timothy D Machajewski
Kris Mendenhall
X Michael Wang
Yi Xia
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR110068A2 publication Critical patent/AR110068A2/es

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto con la fórmula [1], o un esteroisómero, tautómero, sal farmacéuticamente aceptable, o promedicamento del mismo, en donde: Rᵃ se selecciona de un grupo compuesto de (1) hidrógeno, (2) halógeno, (3) hidroxilo, (4) C₁₋₆ alcoxi, (5) tiol, (6) C₁₋₆ alquiltiol, (7) C₁₋₆ alquilo sustituido o no sustituido, (8) amino o amino sustituido, (9) arilo sustituido o no sustituido, (10) heteroarilo sustituido o no sustituido, y (11) heterociclilo sustituido o no sustituido; R se selecciona de un grupo compuesto de: (1) hidrógeno, (2) C₁₋₆ alquilo sustituido o no sustituido, (3) C₂₋₆ alquenilo sustituido o no sustituido, (4) C₂₋₆ alquinilo sustituido o no sustituido, (5) C₂₋₆ cicloalquilo sustituido o no sustituido, (6) C₅₋₇ cicloalquenilo sustituido o no sustituido, (7) arilo sustituido o no sustituido, (8) heteroarilo sustituido o no sustituido, y (9) heterociclilo sustituido o no sustituido; Rᵇ se selecciona de un grupo compuesto de (1) cicloalquilo C₃₋₇ sustituido o no sustituido, (2) cicloalquenilo C₅₋₇ sustituido o no sustituido, (3) arilo sustituido o no sustituido, (4) heteroarilo sustituido o no sustituido, y (5) heterociclilo sustituido o no sustituido; y con la condición de que cuando Rᵃ es amino, entonces Rᵇ no es fenilo, 4-alquilo-fenilo, 4-alcoxi-fenilo, o 4-halo-fenilo.
ARP170103158A 2005-09-30 2017-11-13 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas AR110068A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30

Publications (1)

Publication Number Publication Date
AR110068A2 true AR110068A2 (es) 2019-02-20

Family

ID=40059303

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103158A AR110068A2 (es) 2005-09-30 2017-11-13 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas

Country Status (6)

Country Link
CN (1) CN101287734B (es)
AR (1) AR110068A2 (es)
SI (1) SI1928875T1 (es)
SV (1) SV2008002856A (es)
UA (1) UA93522C2 (es)
ZA (1) ZA200803658B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759010B2 (en) * 2008-09-26 2014-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Host cell kinases as targets for antiviral therapies against HCV infection
MA32933B1 (fr) * 2008-11-28 2012-01-02 Novartis Ag Combinaison d'inhibiteurs de hspo90 et d'herceptine
BRPI0922301A2 (pt) * 2008-11-28 2019-02-26 Novartis Ag combinações de inibidor de hsp90
JP6462155B2 (ja) * 2015-05-04 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療用のＨＢｓＡｇ（ＨＢＶ表面抗原）及びＨＢＶ ＤＮＡ産生の阻害剤としてのテトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
EP3889164A4 (en) * 2018-11-30 2022-11-02 Chugai Seiyaku Kabushiki Kaisha DEPROTECTION METHODS AND RESIN REMOVAL METHODS IN THE SOLID PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND AND METHODS FOR PRODUCTION OF A PEPTIDE COMPOUND
CN109846886A (zh) * 2019-03-26 2019-06-07 中国医学科学院基础医学研究所 Nvp-hsp990在制备治疗癫痫的药物中的用途
WO2021261562A1 (ja) * 2020-06-26 2021-12-30 日本農薬株式会社 アリールテトラヒドロピリジン誘導体又はその塩類及び該化合物を含有する殺虫剤並びにその使用方法
CN114681463B (zh) * 2022-04-29 2024-03-15 暨南大学 Hsp990在制备预防和/或治疗腺病毒感染的药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) * 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd ２−ピペラジノピリミジン誘導体
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
MA21177A1 (fr) * 1987-02-11 1988-10-01 May & Baker Ltd Diones cycliques.

Also Published As

Publication number Publication date
CN101287734A (zh) 2008-10-15
SV2008002856A (es) 2008-06-30
ZA200803658B (en) 2009-09-30
CN101287734B (zh) 2011-07-20
SI1928875T1 (sl) 2011-10-28
UA93522C2 (en) 2011-02-25

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