AR109774A1 - Compuestos heterocíclicos y su uso en la prevención o el tratamiento de infecciones bacterianas - Google Patents

Compuestos heterocíclicos y su uso en la prevención o el tratamiento de infecciones bacterianas

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Publication number
AR109774A1
AR109774A1 ARP170102732A ARP170102732A AR109774A1 AR 109774 A1 AR109774 A1 AR 109774A1 AR P170102732 A ARP170102732 A AR P170102732A AR P170102732 A ARP170102732 A AR P170102732A AR 109774 A1 AR109774 A1 AR 109774A1
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Argentina
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nq1q2
heterocycle
nq1c
nhq3
different
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ARP170102732A
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English (en)
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Mutabilis
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Un compuesto de la fórmula (1), donde R¹ representa un heterociclo de 5 miembros, opcionalmente sustituido con uno o varios T¹, saturado, parcialmente insaturado o aromático que comprende al menos un átomo de nitrógeno, estando ligado el heterociclo con la estructura por el átomo de nitrógeno, al menos uno de los átomos de nitrógeno puede estar cuaternizado; R² representa -SO₃H, -CFHCOOH o -CF₂COOH; T¹, igual o diferente, representa, de modo independiente, un átomo de flúor; =O; -C(O)Q¹; -(CH₂)ₘ-S(O)₂-NQ¹Q²; -(CH₂)ₘ-C(=NOQ¹)Q³; -(X)-(CH₂)ₚ-S(O)₂NQ¹Q²; -C(O)-(CH₂)ₙ-S(O)₂NQ¹Q²; -(CH₂)ₘ-O-(CH₂)ₚ-O-(CH₂)ₚ-NQ¹Q²; -(CH₂)ₘOQ¹; -(CH₂)ₘ-CN; -(CH₂)ₘ-OC(O)Q¹; -(CH₂)ₘ-C(O)OQ¹; -(CH₂)ₘ-OC(O)OQ¹; -(CH₂)ₘ-OC(O)NQ¹Q²; -(CH₂)ₘ-C(O)NQ¹Q²; -(CH₂)ₘ-C(O)ONQ¹Q²; -(CH₂)ₘ-C(O)NQ¹OQ²; -(CH₂)ₘ-C(O)NQ¹-NQ¹Q²; -(CH₂)ₘ-NQ¹C(O)Q²; -(CH₂)ₘ-NQ¹S(O)₂NQ¹Q²; -(CH₂)ₘ-NQ¹S(O)₂Q²; -(CH₂)ₘ-NQ¹C(O)OQ²; -(CH₂)ₘ-NQ¹C(O)NQ¹Q²; -(CH₂)ₘ-NQ¹Q²; -(CH₂)ₘ-NH-C(NHQ³)=NQ⁴; -(CH₂)ₘ-NH-CH=NQ³; -(CH₂)ₘ-C(NHQ³)=NQ⁴; -(X)-(CH₂)ₚOQ¹; -(X)-(CH₂)ₙ-CN; -(X)-(CH₂)ₚ-OC(O)Q¹; -(X)-(CH₂)ₙ-C(O)OQ¹; -(X)-(CH₂)ₚ-OC(O)OQ¹; -(X)-(CH₂)ₚ-OC(O)NQ¹Q²; -(X)-(CH₂)ₙ-C(O)NQ¹Q²; -(X)-(CH₂)ₙ-C(O)ONQ¹Q²; -(X)-(CH₂)ₙ-C(O)NQ¹OQ²; -(X)-(CH₂)ₙ-C(O)NQ¹-NQ¹Q²; -(X)-(CH₂)ₚ-NQ¹C(O)Q²; -(X)-(CH₂)ₚ-NQ¹S(O)₂NQ¹Q²; -(X)-(CH₂)ₚ-NQ¹S(O)₂Q²; -(X)-(CH₂)ₚ-NQ¹C(O)OQ²; -(X)-(CH₂)ₚ-NQ¹C(O)NQ¹Q²; -(X)-(CH₂)ₚ-NQ¹Q²; -(X)-(CH₂)ₚ-NH-C(NHQ³)=NQ⁴; -(X)-(CH₂)ₚ-NH-CH=NQ³; -(X)-(CH₂)ₙ-C(NHQ³)=NQ⁴; -C(O)-(CH₂)ₙOQ¹; -C(O)-(CH₂)ₙ-CN; -C(O)-(CH₂)ₙ-OC(O)Q¹; -C(O)-(CH₂)ₙ-C(O)OQ¹; -C(O)-(CH₂)ₙ-OC(O)OQ¹; -C(O)-(CH₂)ₙ-OC(O)NQ¹Q²; -C(O)-(CH₂)ₙ-C(O)NQ¹Q²; -C(O)-(CH₂)ₙ-C(O)ONQ¹Q²; -C(O)-(CH₂)ₙ-C(O)NQ¹OQ²; -C(O)-(CH₂)ₙ-C(O)NQ¹-NQ¹Q²; -C(O)-(CH₂)ₙ-NQ¹C(O)Q²; -C(O)-(CH₂)ₙ-NQ¹S(O)₂NQ¹Q²; -C(O)-(CH₂)ₙ-NQ¹S(O)₂Q²; -C(O)-(CH₂)ₙ-NQ¹C(O)OQ²; -C(O)-(CH₂)ₙ-NQ¹C(O)NQ¹Q²; -C(O)-(CH₂)ₙ-NQ¹Q²; -C(O)-(CH₂)ₙ-NH-C(NHQ³)=NQ⁴; -C(O)-(CH₂)ₙ-NH-CH=NQ³; -C(O)-(CH₂)ₙ-C(NHQ³)=NQ⁴ o T¹, igual o diferente, representa, de modo independiente, un heterociclo no sustituido o sustituido con uno o varios T², -(CH₂)ₘ-(heterociclo de 4, 5 ó 6 miembros saturado, parcial o totalmente insaturado o aromático); -(X)-(CH₂)ₘ-(heterociclo de 4, 5 ó 6 miembros saturado, parcial o totalmente insaturado o aromático); alquilo C₁₋₃; fluoroalquilo C₁₋₃; -(X)-alquilo C₁₋₃; -(X)-fluoroalquilo C₁₋₃; -(CH₂)ₘ-cicloalquilo C₃₋₆; -(X)-(CH₂)ₘ-cicloalquilo C₃₋₆; -(CH₂)ₘ-ciclofluoroalquilo C₃₋₆; -(X)-(CH₂)ₘ-ciclofluoroalquilo C₃₋₆; -C(O)-(CH₂)ₘ-(heterociclo de 4, 5 ó 6 miembros saturado, parcial o totalmente insaturado o aromático); -C(O)-alquilo C₁₋₃; -C(O)-fluoroalquilo C₁₋₃; -C(O)O-fluoroalquilo C₁₋₃; -C(O)-(CH₂)ₘ-cicloalquilo C₃₋₆; -C(O)-(CH₂)ₘ-cicloalquilo C₃₋₆; -C(O)-(CH₂)ₘ-ciclofluoroalquilo C₃₋₆; -C(O)-(CH₂)ₘ-ciclofluoroalquilo C₃₋₆; T², igual o diferente, representa, de modo independiente, -OH; -NH₂; -CONH₂; Q¹ y Q², iguales o diferentes, representan, de modo independiente, un átomo de hidrógeno; -(CH₂)ʳ-NHQ³; -(CH₂)ʳ-NH-C(NHQ³)=NQ⁴; -(CH₂)ʳ-NH-CH=NQ³; (CH₂)ₙ-C(NHQ³)=NQ⁴; -(CH₂)ʳ-OQ³; -(CH₂)ₙ-CONHQ³; o un alquilo C₁₋₃ no sustituido o sustituido con uno o varios T²; fluoroalquilo C₁₋₃; heterociclo saturado, parcial o totalmente insaturado o aromático-(CH₂)ₘ-(de 4, 5 ó 6 miembros que comprende al menos un átomo de nitrógeno); o Q¹, Q² y el átomo de nitrógeno al que están unidos, forman juntos un heterociclo no sustituido o sustituido con uno o varios T², saturado o parcialmente insaturado de 4, 5 ó 6 miembros que comprende 1, 2 ó 3 heteroátomos; Q³ y Q⁴, iguales o diferentes, representan, de modo independiente, un átomo de hidrógeno o alquilo C₁₋₃; m, igual o diferente, representa, de modo independiente, 0, 1, 2 ó 3; n, igual o diferente, representa, de modo independiente, 1, 2 ó 3; p, igual o diferente, representa, de modo independiente, 2 ó 3; r es 1, 2 ó 3 cuando el (CH₂)ʳ está directamente ligado con un átomo de carbono o 2 ó 3 de otro modo, con preferencia, r es 2 ó 3; X, igual o diferente, representa, de modo independiente, O; S; S(O); S(O)₂ o N(Q³); donde cualquier átomo de carbono presente dentro de un grupo seleccionado de alquilo, cicloalquilo, fluoroalquilo, ciclofluoroalquilo y heterociclo se puede oxidar para formar un grupo C=O; cualquier átomo de azufre presente dentro de un heterociclo se puede oxidar para formar un grupo S=O o un grupo S(O)₂; cualquier átomo de nitrógeno presente dentro de un heterociclo o presente dentro de un grupo donde está trisustituido, formando así un grupo amino terciario, se puede cuaternizar con un grupo metilo; y uno de sus racematos, enantiómeros, diastereoisómeros, isómeros geométricos o una de sus sales farmacéuticamente aceptables, a excepción de los compuestos de fórmula (2), (3) y (4).
ARP170102732A 2016-09-30 2017-09-29 Compuestos heterocíclicos y su uso en la prevención o el tratamiento de infecciones bacterianas AR109774A1 (es)

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EP16306261.5A EP3301094A1 (en) 2016-09-30 2016-09-30 Heterocyclic compounds and their use in preventing or treating bacterial infections

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US (1) US10722520B2 (es)
EP (3) EP3301094A1 (es)
JP (2) JP7089508B2 (es)
KR (1) KR20190065326A (es)
CN (2) CN109906226B (es)
AR (1) AR109774A1 (es)
AU (1) AU2017335222C1 (es)
BR (1) BR112019006371A2 (es)
CA (1) CA3038221A1 (es)
CL (1) CL2019000857A1 (es)
DK (1) DK3519411T3 (es)
ES (1) ES2927528T3 (es)
HR (1) HRP20220831T1 (es)
HU (1) HUE059938T2 (es)
IL (1) IL265676B (es)
LT (1) LT3519411T (es)
MX (1) MX2019003545A (es)
PL (1) PL3519411T3 (es)
PT (1) PT3519411T (es)
RS (1) RS63473B1 (es)
SI (1) SI3519411T1 (es)
TW (1) TWI801353B (es)
WO (1) WO2018060481A1 (es)
ZA (1) ZA201901963B (es)

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EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CA3120371A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
JP2024503893A (ja) * 2021-01-21 2024-01-29 エヌフレクション セラピューティクス インコーポレイテッド ピロロピリジン-アニリン化合物を調製するための方法

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JP6767392B2 (ja) * 2015-05-07 2020-10-14 ミュタビリスMutabilis 複素環式化合物及び細菌感染の治療又は予防におけるその使用
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PL3519411T3 (pl) 2022-08-22
EP3301094A1 (en) 2018-04-04
SI3519411T1 (sl) 2022-08-31
HRP20220831T1 (hr) 2022-09-30
EP3519411B1 (en) 2022-06-22
PT3519411T (pt) 2022-08-25
CL2019000857A1 (es) 2019-08-09
RU2019109177A3 (es) 2020-11-30
AU2017335222A1 (en) 2019-04-11
JP2019530690A (ja) 2019-10-24
KR20190065326A (ko) 2019-06-11
DK3519411T3 (da) 2022-07-11
US20190224210A1 (en) 2019-07-25
HUE059938T2 (hu) 2023-01-28
US10722520B2 (en) 2020-07-28
EP4086255A1 (en) 2022-11-09
ZA201901963B (en) 2021-01-27
CN109906226A (zh) 2019-06-18
AU2017335222B2 (en) 2021-07-15
IL265676A (en) 2019-05-30
CA3038221A1 (en) 2018-04-05
CN113929680A (zh) 2022-01-14
RS63473B1 (sr) 2022-08-31
TW201815791A (zh) 2018-05-01
LT3519411T (lt) 2022-09-12
TWI801353B (zh) 2023-05-11
EP3519411A1 (en) 2019-08-07
JP7089508B2 (ja) 2022-06-22
AU2017335222A2 (en) 2019-05-09
JP2022097520A (ja) 2022-06-30
AU2017335222C1 (en) 2022-01-20
IL265676B (en) 2021-12-01
MX2019003545A (es) 2019-06-17
RU2019109177A (ru) 2020-09-30
WO2018060481A1 (en) 2018-04-05
BR112019006371A2 (pt) 2019-06-25
ES2927528T3 (es) 2022-11-08
CN109906226B (zh) 2021-11-02

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