AR107299A1 - Método para la preparación de isótopos - Google Patents
Método para la preparación de isótoposInfo
- Publication number
- AR107299A1 AR107299A1 ARP170100023A ARP170100023A AR107299A1 AR 107299 A1 AR107299 A1 AR 107299A1 AR P170100023 A ARP170100023 A AR P170100023A AR P170100023 A ARP170100023 A AR P170100023A AR 107299 A1 AR107299 A1 AR 107299A1
- Authority
- AR
- Argentina
- Prior art keywords
- exchange resin
- solution
- eluting
- strong
- base anion
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
- B01J41/05—Processes using organic exchangers in the strongly basic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/60—Cleaning or rinsing ion-exchange beds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F15/00—Compounds of thorium
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
Abstract
Un método para la generación de ²²⁷Th de pureza farmacéuticamente tolerable que comprende i) preparar una mezcla generadora que comprende ²²⁷Ac, ²²⁷Th y ²²³Ra; ii) cargar dicha mezcla generadora en una resina de intercambio aniónico de base fuerte; iii) eluir una mezcla de dichos ²²³Ra y ²²⁷Ac de dicha resina de intercambio aniónico de base fuerte utilizando un primer ácido mineral en una solución acuosa; iv) eluir ²²⁷Th de dicha resina de intercambio aniónico de base fuerte utilizando un segundo ácido mineral en una solución acuosa generando así una primera solución de ²²⁷Th que contiene ²²³Ra y ²²⁷Ac contaminantes; v) cargar la primera solución de ²²⁷Th en una resina de intercambio catiónico de ácido fuerte; vi) eluir por lo menos una parte de los ²²³Ra y ²²⁷Ac contaminantes de dicha resina de intercambio catiónico de ácido fuerte utilizando un tercer ácido mineral en solución acuosa; y vii) eluir el ²²⁷Th de dicha resina de intercambio catiónico de ácido fuerte utilizando una primera solución tampón acuosa para proporcionar una segunda solución de ²²⁷Th. Se proporcionan además torio-227 purificado de pureza farmacéutica y una composición farmacéutica que lo comprende.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1600154.7A GB201600154D0 (en) | 2016-01-05 | 2016-01-05 | Isotope preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107299A1 true AR107299A1 (es) | 2018-04-18 |
Family
ID=55406715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100023A AR107299A1 (es) | 2016-01-05 | 2017-01-05 | Método para la preparación de isótopos |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20190009265A1 (es) |
| EP (1) | EP3400082A1 (es) |
| JP (1) | JP7017511B2 (es) |
| KR (1) | KR20180099705A (es) |
| CN (1) | CN108472555A (es) |
| AR (1) | AR107299A1 (es) |
| AU (1) | AU2016384271B2 (es) |
| BR (1) | BR112018013829A2 (es) |
| CA (1) | CA3010190C (es) |
| CL (1) | CL2018001844A1 (es) |
| CO (1) | CO2018007037A2 (es) |
| GB (1) | GB201600154D0 (es) |
| IL (1) | IL259644B (es) |
| MX (1) | MX2018008340A (es) |
| PE (1) | PE20181454A1 (es) |
| RU (1) | RU2768732C2 (es) |
| SG (2) | SG10202006429YA (es) |
| TW (1) | TWI733732B (es) |
| UA (1) | UA125583C2 (es) |
| UY (1) | UY37066A (es) |
| WO (1) | WO2017118591A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3682959A1 (en) * | 2019-01-16 | 2020-07-22 | Sck Cen | Purification of actinium |
| JP7154414B2 (ja) | 2019-07-02 | 2022-10-17 | 日本メジフィジックス株式会社 | ２２６Ｒａ含有溶液の精製方法、２２６Ｒａターゲットの製造方法および２２５Ａｃの製造方法 |
| CN111398469B (zh) * | 2020-04-09 | 2020-10-27 | 中国科学院地质与地球物理研究所 | 一种小样品量的第四纪土壤碳酸盐的定年方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
| NO310544B1 (no) * | 1999-01-04 | 2001-07-23 | Algeta As | Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben |
| NO313180B1 (no) * | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
| US20060228297A1 (en) * | 2003-04-15 | 2006-10-12 | Roy Larsen | Thorium-227 for use in radiotherapy of soft tissue disease |
| EP1617876B1 (en) * | 2003-04-15 | 2014-05-14 | Algeta AS | Thorium-227 for use in radiotherapy of soft tissue disease |
| KR101247836B1 (ko) * | 2005-06-17 | 2013-03-28 | 와이어쓰 엘엘씨 | 항 ａ 베타 항체의 정제 방법 |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US9951399B2 (en) * | 2014-04-09 | 2018-04-24 | Los Alamos National Security, Llc | Separation of protactinum, actinium, and other radionuclides from proton irradiated thorium target |
-
2016
- 2016-01-05 GB GBGB1600154.7A patent/GB201600154D0/en not_active Ceased
- 2016-12-29 EP EP16820307.3A patent/EP3400082A1/en not_active Withdrawn
- 2016-12-29 CN CN201680077977.0A patent/CN108472555A/zh active Pending
- 2016-12-29 SG SG10202006429YA patent/SG10202006429YA/en unknown
- 2016-12-29 WO PCT/EP2016/082835 patent/WO2017118591A1/en active Application Filing
- 2016-12-29 UA UAA201808336A patent/UA125583C2/uk unknown
- 2016-12-29 JP JP2018535129A patent/JP7017511B2/ja active Active
- 2016-12-29 SG SG11201805459UA patent/SG11201805459UA/en unknown
- 2016-12-29 PE PE2018001255A patent/PE20181454A1/es unknown
- 2016-12-29 CA CA3010190A patent/CA3010190C/en active Active
- 2016-12-29 RU RU2018127822A patent/RU2768732C2/ru active
- 2016-12-29 KR KR1020187018798A patent/KR20180099705A/ko not_active Application Discontinuation
- 2016-12-29 IL IL259644A patent/IL259644B/en unknown
- 2016-12-29 MX MX2018008340A patent/MX2018008340A/es unknown
- 2016-12-29 BR BR112018013829A patent/BR112018013829A2/pt active Search and Examination
- 2016-12-29 US US16/067,146 patent/US20190009265A1/en not_active Abandoned
- 2016-12-29 AU AU2016384271A patent/AU2016384271B2/en not_active Ceased
-
2017
- 2017-01-05 UY UY0001037066A patent/UY37066A/es not_active Application Discontinuation
- 2017-01-05 AR ARP170100023A patent/AR107299A1/es active IP Right Grant
- 2017-01-05 TW TW106100234A patent/TWI733732B/zh not_active IP Right Cessation
-
2018
- 2018-07-05 CL CL2018001844A patent/CL2018001844A1/es unknown
- 2018-07-05 CO CONC2018/0007037A patent/CO2018007037A2/es unknown
-
2020
- 2020-06-10 US US16/897,994 patent/US11452999B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CL2018001844A1 (es) | 2018-10-26 |
| MX2018008340A (es) | 2018-09-17 |
| TW201726586A (zh) | 2017-08-01 |
| UA125583C2 (uk) | 2022-04-27 |
| KR20180099705A (ko) | 2018-09-05 |
| TWI733732B (zh) | 2021-07-21 |
| RU2768732C2 (ru) | 2022-03-24 |
| CA3010190A1 (en) | 2017-07-13 |
| JP7017511B2 (ja) | 2022-02-08 |
| RU2018127822A3 (es) | 2020-03-17 |
| EP3400082A1 (en) | 2018-11-14 |
| IL259644B (en) | 2022-08-01 |
| CN108472555A (zh) | 2018-08-31 |
| UY37066A (es) | 2017-08-31 |
| GB201600154D0 (en) | 2016-02-17 |
| AU2016384271B2 (en) | 2022-05-12 |
| US11452999B2 (en) | 2022-09-27 |
| US20200406247A1 (en) | 2020-12-31 |
| SG11201805459UA (en) | 2018-07-30 |
| WO2017118591A1 (en) | 2017-07-13 |
| CO2018007037A2 (es) | 2018-07-19 |
| US20190009265A1 (en) | 2019-01-10 |
| BR112018013829A2 (pt) | 2018-12-11 |
| PE20181454A1 (es) | 2018-09-12 |
| IL259644A (en) | 2018-07-31 |
| SG10202006429YA (en) | 2020-08-28 |
| JP2019509467A (ja) | 2019-04-04 |
| AU2016384271A1 (en) | 2018-06-21 |
| RU2018127822A (ru) | 2020-02-06 |
| CA3010190C (en) | 2023-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |