SG11201805459UA - Isotope preparation method - Google Patents
Isotope preparation methodInfo
- Publication number
- SG11201805459UA SG11201805459UA SG11201805459UA SG11201805459UA SG11201805459UA SG 11201805459U A SG11201805459U A SG 11201805459UA SG 11201805459U A SG11201805459U A SG 11201805459UA SG 11201805459U A SG11201805459U A SG 11201805459UA SG 11201805459U A SG11201805459U A SG 11201805459UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- eluting
- exchange resin
- strong
- solution
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
- B01J41/05—Processes using organic exchangers in the strongly basic form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/60—Cleaning or rinsing ion-exchange beds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F15/00—Compounds of thorium
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111011111111110111111011111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number ..... ....!;,„./ (43) International Publication Date WO 2017/118591 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: BIP PATENTS; c/o Bayer Intellectual Property BOlD 15/18 (2006.01) B01J 41/05 (2017.01) GmbH, Alfred-Nobel-Str. 10, 40789 Monheim am Rhein A61K 51/06 (2006.01) A61K 51/12 (2006.01) (DE). BOlD 15/36 (2006.01) G21G 1/00 (2006.01) BO1J 39/05 (2017.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/EP2016/082835 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 29 December 2016 (29.12.2016) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 1600154.7 5 January 2016 (05.01.2016) GB ZA, ZM, ZW. (71) Applicant: BAYER AS [NO/NO]; Drammensveien 288, (84) Designated States (unless otherwise indicated, for every 0283 Oslo (NO). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: MANTZILAS, Dimitrios; Hans Hammerens TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Veg 18, 1920 Sorumsand (NO). KARLSON, Jan Roger; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Normanngata 42, 0655 Oslo (NO). OSTBY, Judit Tjelme- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = land; Lokenveien 5, 1408 Krakstad (NO). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = — GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] — = Title: ISOTOPE PREPARATION METHOD (54) a....11..6 ro .,„„„„..„, (57) : The present invention comprises a method for the generation — _ of 227 Th of pharmaceutically tolerable purity comprising i) preparing a gen- erator mixture comprising 227 Ac, 227 Th and 223 Ra; ii) loading said generator = _ \"VZ.' . ;!`.77 m ' fV r' ' ,, ,a' '-- . v....... mixture onto a strong base anion exchange resin; iii) eluting a mixture of ...Mar dr,las = 223 227 said Ra and Ac from said strong base anion exchange resin using a = b4.. 1bmao122,4 iu 1.3 ARM ___>, first mineral acid in an aqueous solution; iv) eluting Th from said strong 227 base anion exchange resin using a second mineral acid in an aqueous solu- = y = , ..altfl,, ,-, Z:>\";1;.7ZZ. tion whereby to generate a first 227 Th solution containing contaminant 2 \" Ra — 1 3 Ad HC1 j (ani.x. wimp teibl) and 227 Ac; v) loading the first 227 Th solution onto a strong acid cation ex- -- + If (4b) 1 change resin; vi) eluting at least a part of the contaminant 223 Ra and 227 Ac = iv I u3 EIGI i al. [ BM. = »<U..n., from said strong acid cation exchange resin using a third mineral acid in = aqueous solution; and vii) eluting the 227 Th from said strong acid cation ex- change resin using a first aqueous buffer solution to provide a second Th 227 /SARIN°. I r , '\"11 .21.‘lcadoc *I a~vmcbeaua ramp = L 1 10 Nti....'0 ^Shd HO, „tie — solution. Purified thorium-227 of pharmaceutical purity and a pharmaceutic - ay.. : NII.A.30, al composition comprising the same are also provided. * Id M NNO, I -4 Ac0.15mEpa cv..nt el..te — Nfr = I i MEM. ,.. .11, nc '2111ead t2 — I --> 31.0 ''''''''wh'W '='\" Il Ifthtla,AeliOng I 311i; '\" I Napansbw of .Tb e:ux.. 11 CiN f....arm.vd) ir) ; 10, Q,-,.. phDs zleese ....8,t Ittnri.an.2rebiertde GC eyedauibw Il Il ......., Figure 1 - Manufacturing process and process control IN 11 © N O WO 2017/118591 Al 1#11101MOMMIONOMOMOIEMEHMOIMMOIMIE Declarations under Rule 4.17: Published: — as to applicant's entitlement a patent (Rule 4.1700) to apply for and be granted — with international search report (Art. 21(3))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1600154.7A GB201600154D0 (en) | 2016-01-05 | 2016-01-05 | Isotope preparation method |
| PCT/EP2016/082835 WO2017118591A1 (en) | 2016-01-05 | 2016-12-29 | Isotope preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805459UA true SG11201805459UA (en) | 2018-07-30 |
Family
ID=55406715
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202006429YA SG10202006429YA (en) | 2016-01-05 | 2016-12-29 | Isotope preparation method |
| SG11201805459UA SG11201805459UA (en) | 2016-01-05 | 2016-12-29 | Isotope preparation method |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202006429YA SG10202006429YA (en) | 2016-01-05 | 2016-12-29 | Isotope preparation method |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20190009265A1 (en) |
| EP (1) | EP3400082A1 (en) |
| JP (1) | JP7017511B2 (en) |
| KR (1) | KR20180099705A (en) |
| CN (1) | CN108472555A (en) |
| AR (1) | AR107299A1 (en) |
| AU (1) | AU2016384271B2 (en) |
| BR (1) | BR112018013829A2 (en) |
| CA (1) | CA3010190C (en) |
| CL (1) | CL2018001844A1 (en) |
| CO (1) | CO2018007037A2 (en) |
| GB (1) | GB201600154D0 (en) |
| IL (1) | IL259644B (en) |
| MX (1) | MX2018008340A (en) |
| PE (1) | PE20181454A1 (en) |
| RU (1) | RU2768732C2 (en) |
| SG (2) | SG10202006429YA (en) |
| TW (1) | TWI733732B (en) |
| UA (1) | UA125583C2 (en) |
| UY (1) | UY37066A (en) |
| WO (1) | WO2017118591A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3682959A1 (en) * | 2019-01-16 | 2020-07-22 | Sck Cen | Purification of actinium |
| JP7154414B2 (en) | 2019-07-02 | 2022-10-17 | 日本メジフィジックス株式会社 | Method for Purifying 226Ra-Containing Solution, Method for Producing 226Ra Target, and Method for Producing 225Ac |
| CN111398469B (en) * | 2020-04-09 | 2020-10-27 | 中国科学院地质与地球物理研究所 | Dating method for quaternary soil carbonate with small sample amount |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
| NO310544B1 (en) * | 1999-01-04 | 2001-07-23 | Algeta As | Preparation and use of radium-223 for the preparation of preparations and kits for the treatment of calcified tissue for palliation, bone cancer therapy and / or bone surface treatment |
| NO313180B1 (en) * | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Visiting alpha particles emitting radiopharmaceuticals |
| US20060228297A1 (en) * | 2003-04-15 | 2006-10-12 | Roy Larsen | Thorium-227 for use in radiotherapy of soft tissue disease |
| EP1617876B1 (en) * | 2003-04-15 | 2014-05-14 | Algeta AS | Thorium-227 for use in radiotherapy of soft tissue disease |
| KR101247836B1 (en) * | 2005-06-17 | 2013-03-28 | 와이어쓰 엘엘씨 | Methods of purifying anti a beta antibodies |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US9951399B2 (en) * | 2014-04-09 | 2018-04-24 | Los Alamos National Security, Llc | Separation of protactinum, actinium, and other radionuclides from proton irradiated thorium target |
-
2016
- 2016-01-05 GB GBGB1600154.7A patent/GB201600154D0/en not_active Ceased
- 2016-12-29 EP EP16820307.3A patent/EP3400082A1/en not_active Withdrawn
- 2016-12-29 CN CN201680077977.0A patent/CN108472555A/en active Pending
- 2016-12-29 SG SG10202006429YA patent/SG10202006429YA/en unknown
- 2016-12-29 WO PCT/EP2016/082835 patent/WO2017118591A1/en active Application Filing
- 2016-12-29 UA UAA201808336A patent/UA125583C2/en unknown
- 2016-12-29 JP JP2018535129A patent/JP7017511B2/en active Active
- 2016-12-29 SG SG11201805459UA patent/SG11201805459UA/en unknown
- 2016-12-29 PE PE2018001255A patent/PE20181454A1/en unknown
- 2016-12-29 CA CA3010190A patent/CA3010190C/en active Active
- 2016-12-29 RU RU2018127822A patent/RU2768732C2/en active
- 2016-12-29 KR KR1020187018798A patent/KR20180099705A/en not_active Application Discontinuation
- 2016-12-29 IL IL259644A patent/IL259644B/en unknown
- 2016-12-29 MX MX2018008340A patent/MX2018008340A/en unknown
- 2016-12-29 BR BR112018013829A patent/BR112018013829A2/en active Search and Examination
- 2016-12-29 US US16/067,146 patent/US20190009265A1/en not_active Abandoned
- 2016-12-29 AU AU2016384271A patent/AU2016384271B2/en not_active Ceased
-
2017
- 2017-01-05 UY UY0001037066A patent/UY37066A/en not_active Application Discontinuation
- 2017-01-05 AR ARP170100023A patent/AR107299A1/en active IP Right Grant
- 2017-01-05 TW TW106100234A patent/TWI733732B/en not_active IP Right Cessation
-
2018
- 2018-07-05 CL CL2018001844A patent/CL2018001844A1/en unknown
- 2018-07-05 CO CONC2018/0007037A patent/CO2018007037A2/en unknown
-
2020
- 2020-06-10 US US16/897,994 patent/US11452999B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CL2018001844A1 (en) | 2018-10-26 |
| MX2018008340A (en) | 2018-09-17 |
| TW201726586A (en) | 2017-08-01 |
| UA125583C2 (en) | 2022-04-27 |
| AR107299A1 (en) | 2018-04-18 |
| KR20180099705A (en) | 2018-09-05 |
| TWI733732B (en) | 2021-07-21 |
| RU2768732C2 (en) | 2022-03-24 |
| CA3010190A1 (en) | 2017-07-13 |
| JP7017511B2 (en) | 2022-02-08 |
| RU2018127822A3 (en) | 2020-03-17 |
| EP3400082A1 (en) | 2018-11-14 |
| IL259644B (en) | 2022-08-01 |
| CN108472555A (en) | 2018-08-31 |
| UY37066A (en) | 2017-08-31 |
| GB201600154D0 (en) | 2016-02-17 |
| AU2016384271B2 (en) | 2022-05-12 |
| US11452999B2 (en) | 2022-09-27 |
| US20200406247A1 (en) | 2020-12-31 |
| WO2017118591A1 (en) | 2017-07-13 |
| CO2018007037A2 (en) | 2018-07-19 |
| US20190009265A1 (en) | 2019-01-10 |
| BR112018013829A2 (en) | 2018-12-11 |
| PE20181454A1 (en) | 2018-09-12 |
| IL259644A (en) | 2018-07-31 |
| SG10202006429YA (en) | 2020-08-28 |
| JP2019509467A (en) | 2019-04-04 |
| AU2016384271A1 (en) | 2018-06-21 |
| RU2018127822A (en) | 2020-02-06 |
| CA3010190C (en) | 2023-07-11 |
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