AR106085A1 - Formulaciones de olanzapina de liberación sostenida - Google Patents
Formulaciones de olanzapina de liberación sostenidaInfo
- Publication number
- AR106085A1 AR106085A1 ARP160102864A ARP160102864A AR106085A1 AR 106085 A1 AR106085 A1 AR 106085A1 AR P160102864 A ARP160102864 A AR P160102864A AR P160102864 A ARP160102864 A AR P160102864A AR 106085 A1 AR106085 A1 AR 106085A1
- Authority
- AR
- Argentina
- Prior art keywords
- poly
- olanzapine
- sustained release
- acid
- pharmaceutically acceptable
- Prior art date
Links
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005017 olanzapine Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920002988 biodegradable polymer Polymers 0.000 abstract 2
- 239000004621 biodegradable polymer Substances 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VSKXVGWORBZZDY-UHFFFAOYSA-N 2-hydroxypropanoic acid;oxepan-2-one Chemical compound CC(O)C(O)=O.O=C1CCCCCO1 VSKXVGWORBZZDY-UHFFFAOYSA-N 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 229920001661 Chitosan Polymers 0.000 abstract 1
- 229920002732 Polyanhydride Polymers 0.000 abstract 1
- 229920001710 Polyorthoester Polymers 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 abstract 1
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
- 229940065514 poly(lactide) Drugs 0.000 abstract 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 abstract 1
- 229920002627 poly(phosphazenes) Polymers 0.000 abstract 1
- 229920001610 polycaprolactone Polymers 0.000 abstract 1
- 239000004632 polycaprolactone Substances 0.000 abstract 1
- 239000000622 polydioxanone Substances 0.000 abstract 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 abstract 1
- 229920002635 polyurethane Polymers 0.000 abstract 1
- 239000004814 polyurethane Substances 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
Métodos para tratar la esquizofrenia o el trastorno bipolar administrando por vía subcutánea una forma de dosificación de liberación sostenida de olanzapina, o una sal farmacéuticamente aceptable de la misma. También se describen métodos para administrar por vía subcutánea olanzapina, o una sal farmacéuticamente aceptable de la misma. Reivindicación 9: El método de acuerdo con la reivindicación 1, en donde la forma de dosificación farmacéutica además comprende por lo menos un polímero biodegradable. Reivindicación 10: El método de acuerdo con la reivindicación 9, en donde dicho por lo menos un polímero biodegradable es una poli(lactida), poli(glicolido), poli(lactida con glicolido), poli-1-(ácidos carboxílicos alifáticos), copolioxalatos, policaprolactona, polidioxanona, poli(orto carbonatos), poli(acetales), poli(ácido láctido-caprolactona), poliortoésteres, poli(ácido glicólico-captolactona), poli(aminoácido), poliésteramida, polianhídridos, polifosfacinas, poli(alquilato de alquileno), poliuretano biodegradable, polivinilpirrolidona, ácido polialcanoico, polietilenglicol, copolímero de polietilenglicol y poliortoéster, albúmina, quitosano, caseína, ceras o mezclas o copolímeros de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562221290P | 2015-09-21 | 2015-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106085A1 true AR106085A1 (es) | 2017-12-13 |
Family
ID=57047342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102864A AR106085A1 (es) | 2015-09-21 | 2016-09-21 | Formulaciones de olanzapina de liberación sostenida |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20170079985A1 (es) |
| EP (2) | EP3352735B1 (es) |
| JP (2) | JP2018527397A (es) |
| KR (1) | KR20180054627A (es) |
| CN (2) | CN108289834A (es) |
| AR (1) | AR106085A1 (es) |
| AU (2) | AU2016328958B2 (es) |
| CA (1) | CA2998504C (es) |
| CL (1) | CL2018000727A1 (es) |
| DK (1) | DK3352735T3 (es) |
| EA (1) | EA201890788A1 (es) |
| ES (1) | ES2960753T3 (es) |
| FI (1) | FI3352735T3 (es) |
| HK (1) | HK1255946A1 (es) |
| HU (1) | HUE063850T2 (es) |
| IL (3) | IL295161A (es) |
| MX (2) | MX2018003380A (es) |
| NZ (1) | NZ740665A (es) |
| PL (1) | PL3352735T3 (es) |
| PT (1) | PT3352735T (es) |
| TW (1) | TWI798161B (es) |
| WO (1) | WO2017053346A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3057438A1 (en) | 2017-03-20 | 2018-09-27 | Teva Pharmaceuticals International Gmbh | Sustained release olanzapine formulaitons |
| EP3735223A4 (en) * | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE |
| CN112587505A (zh) * | 2020-10-16 | 2021-04-02 | 长春斯菲尔生物科技有限公司 | 一种奥氮平双羟萘酸盐缓释微粒制剂及其制备方法 |
Family Cites Families (44)
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| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| EP1018880A4 (en) * | 1997-09-30 | 2006-06-14 | Lilly Co Eli | FORMULATION OF 2-METHYL-THIENO-BENZODIAZEPINE |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| DE602004016995D1 (de) | 2003-06-26 | 2008-11-20 | Control Delivery Sys Inc | In-situ gelierendes arzneimittelabgabesystem |
| EP1711124A4 (en) | 2004-01-12 | 2011-06-01 | Univ Pennsylvania | LONG-TERM RELEASE PREPARATIONS AND METHODS OF USE THEREOF |
| EP1576952A1 (en) | 2004-03-18 | 2005-09-21 | OctoPlus Technologies B.V. | Hydrogel microspheres with improved release profile |
| NL1026261C2 (nl) | 2004-05-25 | 2005-11-28 | Nanomi B V | Sproei inrichting met een nozzleplaat voorzien van structuren ter bevordering van self-breakup, een nozzleplaat, alsmede werkwijzen ter vervaardiging en toepassing van een dergelijke nozzleplaat. |
| JP5127449B2 (ja) | 2004-06-04 | 2013-01-23 | カムルス エービー | 流体デポ製剤 |
| BRPI0518187A (pt) * | 2004-11-16 | 2008-11-04 | Elan Pharma Int Ltd | formulações de olanzapina em nanopartìcula injetáveis |
| EP1874267A1 (en) * | 2005-04-13 | 2008-01-09 | Pfizer Products Inc. | Injectable depot formulations and methods for providing sustained release of poorly soluble drugs comprising nanoparticles |
| KR20070119678A (ko) * | 2005-04-13 | 2007-12-20 | 화이자 프로덕츠 인코포레이티드 | 지속 방출되는 나노입자 조성물을 제공하기 위한주사가능한 저장소 제제 및 방법 |
| US7829554B2 (en) * | 2005-07-14 | 2010-11-09 | Lithera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| WO2007139744A2 (en) | 2006-05-23 | 2007-12-06 | Titan Pharmaceuticals, Inc. | Implantable polymeric device for sustained release of buprenorphine with minimal initial burst |
| CA2657911C (en) | 2006-07-11 | 2012-02-21 | Quest Pharmaceutical Services, Llc | Pharmaceutical compositions for sustained release delivery of peptides |
| FI20070174A0 (fi) | 2007-02-28 | 2007-02-28 | Delsitech Oy | Menetelmä silikakoostumusten valmistamiseksi, silikakoostumukset ja niiden käytöt |
| KR100805208B1 (ko) | 2007-03-27 | 2008-02-21 | 주식회사 펩트론 | 엑센딘 함유 서방성 제제 조성물, 엑센딘 함유 서방성미립구 및 이의 제조 방법 |
| AU2008241699B2 (en) | 2007-04-19 | 2011-02-03 | Dong-A Pharmaceutical. Co., Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| NZ581862A (en) | 2007-05-25 | 2012-06-29 | Tolmar Therapeutics Inc | Injectable subcutaneous formulation comprising risperidone capable of forming a solid, microporous implant in a patient |
| ES2324009B1 (es) | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
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2016
- 2016-09-21 EA EA201890788A patent/EA201890788A1/ru unknown
- 2016-09-21 JP JP2018515050A patent/JP2018527397A/ja active Pending
- 2016-09-21 IL IL295161A patent/IL295161A/en unknown
- 2016-09-21 FI FIEP16775424.1T patent/FI3352735T3/fi active
- 2016-09-21 WO PCT/US2016/052757 patent/WO2017053346A1/en active Application Filing
- 2016-09-21 NZ NZ740665A patent/NZ740665A/en unknown
- 2016-09-21 CN CN201680066464.XA patent/CN108289834A/zh active Pending
- 2016-09-21 PL PL16775424.1T patent/PL3352735T3/pl unknown
- 2016-09-21 PT PT167754241T patent/PT3352735T/pt unknown
- 2016-09-21 CA CA2998504A patent/CA2998504C/en active Active
- 2016-09-21 ES ES16775424T patent/ES2960753T3/es active Active
- 2016-09-21 MX MX2018003380A patent/MX2018003380A/es unknown
- 2016-09-21 EP EP16775424.1A patent/EP3352735B1/en active Active
- 2016-09-21 HU HUE16775424A patent/HUE063850T2/hu unknown
- 2016-09-21 AR ARP160102864A patent/AR106085A1/es unknown
- 2016-09-21 KR KR1020187007791A patent/KR20180054627A/ko not_active Application Discontinuation
- 2016-09-21 CN CN202310947482.0A patent/CN116942677A/zh active Pending
- 2016-09-21 EP EP23193256.7A patent/EP4331570A1/en active Pending
- 2016-09-21 US US15/271,508 patent/US20170079985A1/en not_active Abandoned
- 2016-09-21 DK DK16775424.1T patent/DK3352735T3/da active
- 2016-09-21 TW TW105130439A patent/TWI798161B/zh active
- 2016-09-21 AU AU2016328958A patent/AU2016328958B2/en active Active
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2018
- 2018-03-13 IL IL258086A patent/IL258086A/en unknown
- 2018-03-16 MX MX2022007315A patent/MX2022007315A/es unknown
- 2018-03-20 CL CL2018000727A patent/CL2018000727A1/es unknown
- 2018-05-17 US US15/982,449 patent/US20180264001A1/en not_active Abandoned
- 2018-11-23 HK HK18115019.5A patent/HK1255946A1/zh unknown
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2020
- 2020-06-29 IL IL275735A patent/IL275735A/en unknown
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2021
- 2021-07-01 JP JP2021110240A patent/JP2021167331A/ja active Pending
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2022
- 2022-06-23 US US17/847,685 patent/US20220323458A1/en not_active Abandoned
- 2022-07-18 AU AU2022206695A patent/AU2022206695A1/en active Pending
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2024
- 2024-04-01 US US18/623,327 patent/US20240238307A1/en active Pending
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
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