AR097202A1 - Composiciones farmacéuticas de ranolazina y dronedarona, procedimiento para elaborar tableta bicapa - Google Patents
Composiciones farmacéuticas de ranolazina y dronedarona, procedimiento para elaborar tableta bicapaInfo
- Publication number
- AR097202A1 AR097202A1 ARP140102908A ARP140102908A AR097202A1 AR 097202 A1 AR097202 A1 AR 097202A1 AR P140102908 A ARP140102908 A AR P140102908A AR P140102908 A ARP140102908 A AR P140102908A AR 097202 A1 AR097202 A1 AR 097202A1
- Authority
- AR
- Argentina
- Prior art keywords
- ranolazine
- dronedarone
- bicapa
- bilayer tablet
- tablet
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición sólida que comprende ranolazina y una sal de ácido fosfórico de dronedarona secada por aspersión en una tableta bicapa. Reivindicación 1: Una tableta bicapa que comprende ranolazina y uno o más excipientes farmacéuticamente aceptables en una primera capa, y una formulación sólida estable de una sal de acido fosfórico secada por aspersión de dronedarona que además comprende HPMC E3 o HPMC E5 y uno o más excipientes farmacéuticamente aceptables en una segunda capa. Reivindicación 2: La tableta bicapa de acuerdo con la reivindicación 1, en donde la primera capa comprende una formulación de liberación sostenida de ranolazina. Reivindicación 7: La tableta bicapa de acuerdo con cualquiera de las reivindicaciones 1 a 6, que comprende entre aproximadamente 200 mg y aproximadamente 1500 mg de ranolazina y entre aproximadamente 50 mg y aproximadamente 400 mg de equivalente base de dronedarona de la formulación de una sal de ácido fosfórico secada por aspersión de dronedarona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361861862P | 2013-08-02 | 2013-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR097202A1 true AR097202A1 (es) | 2016-02-24 |
Family
ID=51359424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140102908A AR097202A1 (es) | 2013-08-02 | 2014-08-01 | Composiciones farmacéuticas de ranolazina y dronedarona, procedimiento para elaborar tableta bicapa |
Country Status (18)
Country | Link |
---|---|
US (2) | US20150037410A1 (es) |
EP (1) | EP3027175A1 (es) |
JP (1) | JP6141580B2 (es) |
KR (1) | KR20160027078A (es) |
CN (1) | CN105682642A (es) |
AR (1) | AR097202A1 (es) |
AU (1) | AU2014296378B2 (es) |
BR (1) | BR112016001779A2 (es) |
CA (1) | CA2919720A1 (es) |
EA (1) | EA201690216A1 (es) |
HK (1) | HK1225632A1 (es) |
IL (1) | IL243390A0 (es) |
MX (1) | MX2016001303A (es) |
NZ (1) | NZ715615A (es) |
SG (1) | SG11201600104VA (es) |
TW (1) | TW201536356A (es) |
UY (1) | UY35690A (es) |
WO (1) | WO2015017441A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018001582A1 (en) * | 2016-06-30 | 2018-01-04 | Interquim, S.A. | Ranolazine multiple compressed tablets |
US10898444B2 (en) | 2017-06-01 | 2021-01-26 | Sun Pharmaceutical Industries Limited | Extended release multiparticulates of ranolazine |
CN112438955A (zh) * | 2019-08-30 | 2021-03-05 | 深圳翰宇药业股份有限公司 | 一种雷诺嗪缓释组合物及其制备方法 |
CN110859843A (zh) * | 2019-12-17 | 2020-03-06 | 卓和药业集团有限公司 | 一种治疗动脉硬化合并心绞痛的药物组合物及制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA89065C2 (ru) * | 2004-11-05 | 2009-12-25 | Бёрингэр Ингэльхайм Интэрнациональ Гмбх | Двухслойная таблетка, которая содержит телмисартан и амлодипин |
TWI508726B (zh) * | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
CN102342907A (zh) * | 2010-07-30 | 2012-02-08 | 江苏恒瑞医药股份有限公司 | 决奈达隆固体分散体及其制备方法 |
JP2013535516A (ja) * | 2010-08-17 | 2013-09-12 | ルピン・リミテッド | ドロネダロンの制御放出製剤 |
-
2014
- 2014-07-29 MX MX2016001303A patent/MX2016001303A/es unknown
- 2014-07-29 BR BR112016001779A patent/BR112016001779A2/pt not_active Application Discontinuation
- 2014-07-29 SG SG11201600104VA patent/SG11201600104VA/en unknown
- 2014-07-29 CN CN201480042943.9A patent/CN105682642A/zh active Pending
- 2014-07-29 EP EP14752964.8A patent/EP3027175A1/en not_active Withdrawn
- 2014-07-29 NZ NZ715615A patent/NZ715615A/en not_active IP Right Cessation
- 2014-07-29 EA EA201690216A patent/EA201690216A1/ru unknown
- 2014-07-29 KR KR1020167002470A patent/KR20160027078A/ko not_active Application Discontinuation
- 2014-07-29 US US14/445,986 patent/US20150037410A1/en not_active Abandoned
- 2014-07-29 JP JP2016530100A patent/JP6141580B2/ja not_active Expired - Fee Related
- 2014-07-29 CA CA2919720A patent/CA2919720A1/en not_active Abandoned
- 2014-07-29 AU AU2014296378A patent/AU2014296378B2/en not_active Ceased
- 2014-07-29 WO PCT/US2014/048674 patent/WO2015017441A1/en active Application Filing
- 2014-07-31 TW TW103126305A patent/TW201536356A/zh unknown
- 2014-08-01 UY UY0001035690A patent/UY35690A/es not_active Application Discontinuation
- 2014-08-01 AR ARP140102908A patent/AR097202A1/es unknown
-
2015
- 2015-12-29 IL IL243390A patent/IL243390A0/en unknown
-
2016
- 2016-04-06 US US15/092,126 patent/US20160213569A1/en not_active Abandoned
- 2016-12-08 HK HK16113992A patent/HK1225632A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IL243390A0 (en) | 2016-02-29 |
US20160213569A1 (en) | 2016-07-28 |
EP3027175A1 (en) | 2016-06-08 |
WO2015017441A1 (en) | 2015-02-05 |
BR112016001779A2 (pt) | 2017-08-01 |
CN105682642A (zh) | 2016-06-15 |
KR20160027078A (ko) | 2016-03-09 |
UY35690A (es) | 2014-09-30 |
AU2014296378A1 (en) | 2016-01-28 |
AU2014296378B2 (en) | 2017-03-30 |
SG11201600104VA (en) | 2016-02-26 |
US20150037410A1 (en) | 2015-02-05 |
EA201690216A1 (ru) | 2016-08-31 |
NZ715615A (en) | 2017-06-30 |
HK1225632A1 (zh) | 2017-09-15 |
JP2016525554A (ja) | 2016-08-25 |
TW201536356A (zh) | 2015-10-01 |
MX2016001303A (es) | 2016-04-07 |
CA2919720A1 (en) | 2015-02-05 |
JP6141580B2 (ja) | 2017-06-07 |
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Legal Events
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FB | Suspension of granting procedure |